Red Man Syndrome Adverse Reaction following Intravenous Infusion of Cefepime

Panos, George; Watson, Dionysios C.; Σαργιάνου, Μαρία; Kampiotis, Dionysios; Chra, Paraskevi

doi:10.1128/aac.01274-12

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…The standard meta-analytic techniques were employed for data extraction. [4] Calculations were performed manually, with the use of the Statistical Package for Social Sciences, [5] as a second point of reference. The Pearson correlation coefficient r was used as the effect size measure, given that it was applicable to statistical analyses of repeated measures.…”

Section: Pindolol Augmentation Of Selective Serotonin Reuptake Inhibi...mentioning

confidence: 99%

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Stevens-Johnson syndrome caused by cefepime?

Mavilia¹,

Trifirò²,

Mercuri³

2015

Journal of Pharmacology and Pharmacotherapeutics

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Section: Pindolol Augmentation Of Selective Serotonin Reuptake Inhibi...mentioning

confidence: 99%

“…Other than urticaria, among the skin conditions caused by cefepime described in scientific literature, red man syndrome,[ 4 ] acute generalized exanthematous pustolosis[ 5 ] and the case of SJS to which we make reference, induced by phenytoin and exacerbated by cefepime,[ 6 ] can be found.…”

mentioning

confidence: 99%

Stevens-Johnson syndrome caused by cefepime?

Mavilia¹,

Trifirò²,

Mercuri³

2015

Journal of Pharmacology and Pharmacotherapeutics

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“…2,3 Even though it typically occurs after vancomycin administration, a few literature studies and data collected from various spontaneous reporting systems under FDA suggested the possible involvement of ciprofloxacin, amphotericin B, rifampin, cefepime, teicoplanin, adalimumab, infliximab and teicoplanin. [4][5][6][7] Currently, a proposal put forth by The Infectious Diseases Society of America, The Society for Healthcare Epidemiology of America (SHEA) and the Paediatric Infectious Diseases Society (PIDS) have been granted to rename the disease terminology to 'Vancomycin Flushing Syndrome'. However, it has not been updated in the electronic health records and databases.…”

Section: What Is Known and Objectivementioning

confidence: 99%

Drugs‐associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip

Shaju

Panicker

Chandni

et al. 2022

Clinical Pharmacy Therapeu

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What is known and objective Red man syndrome (RMS) is a non‐IgE‐mediated anaphylactoid adverse event frequently witnessed after a rapid infusion of vancomycin. This study aims to unravel drugs and associated off‐label targets that induce RMS by exploiting FDA Adverse Event Reporting System (FAERS) and Pharmacovigilance/Pharmacogenomics Insilico Pipeline (PHARMIP). Methods The case/non‐case retrospective observational study was conducted in the FAERS database. Reporting odds ratio (ROR) and proportional reporting ratio (PRR) data mining algorithms were used to evaluate the strength of the signal. The off‐label targets of the drugs with potential signals were obtained using online servers by applying a similarity ensemble approach and a reverse pharmacophore database, which was further validated by molecular docking studies. Results and discussion Oritavancin exhibited a strong positive signal (PRR:1185.20 and ROR:1256), which suggests a higher risk for causing RMS. The literature search revealed the involvement of the MRGPRX2 gene in the development of RMS. PHARMIP study unearthed Carbonic anhydrase II (CA2) as the common off‐label target among the drugs causing RMS. The results obtained from molecular docking studies reinforced the findings as mentioned earlier, wherein the highest docking score was disinterred for oritavancin (−9.4 for MRGPRX2 and − 8.7 for CA2). What is new and conclusion Many antibiotics and other classes of medications have been discovered in the quest for drugs that may induce RMS, although a causal relationship could not be established. The implication of MRGPX2 and CA2 in the initial stages of pathogenesis necessitates the development of inhibitors that could be used as potential therapeutic agents against RMS.

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“…Eine Sonderform der Antibiotikaunverträglichkeit, die allerdings auch durch andere Arzneimittel ausgelöst werden kann, ist das "Red-Man-Syndrom" [44]. Die Betroffenen entwickeln unmittelbar nach Arzneimittelapplikation ein Flush-artiges, generalisiertes Erythem, das durch eine direkte Histaminfreisetzung verursacht wird und zumeist gut auf eine Antihistaminikagabe anspricht [45]. Obwohl es nicht allergisch bedingt ist, kann es bei erneuter Gabe des auslösenden Medikaments wieder auftreten, was sich häufig, aber nicht regelhaft, durch eine verlangsamte Infusionsgeschwindigkeit vermeiden lässt [45].…”

Section: Red-man-syndromunclassified

Perioperative Anaphylaxie auf Arzneimittel

Pfützner¹,

Wulf²

2017

Anästhesiol Intensivmed Notfallmed Schmerzther

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The diagnostic evaluation of perioperative anaphylaxia is of great importance for the medical care of the affected persons in the context of renewed interventions in general anesthesia. The most frequent triggers include muscle relaxants, antibiotics, latex and analgesics of the type of the cyclooxygenase inhibitors, but other perioperatively administered drugs such as opioids, anesthetics, benzodiazepines, dyes, disinfectants and even corticosteroids or drug additives may also be the cause in rare cases. The most important aim is therefore the identification of the responsible drug, for which a near-time allergological diagnosis should be carried out within the first 4 weeks to 6 months after the reaction. At the end of the examinations, the patient receives a structured allergy passport, which includes information on the drug reaction, the triggers and alternative medicines, as well as possible preventive measures for future surgical procedures. It should be noted, however, that the latter are not a guarantee that, upon renewed exposure to the causative medicinal product, there will be no, possibly even heavier, anaphylactic reaction.

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Red Man Syndrome Adverse Reaction following Intravenous Infusion of Cefepime

Cited by 7 publications

References 9 publications

Stevens-Johnson syndrome caused by cefepime?

Stevens-Johnson syndrome caused by cefepime?

Drugs‐associated with red man syndrome: An integrative approach using disproportionality analysis and Pharmip

Perioperative Anaphylaxie auf Arzneimittel

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