SummaryObjectiveTo describe differences in weight loss (WL) trajectory patterns at a publicly funded clinical weight management centre.MethodsGroups with differences in the attainment of a 5% total body WL and percentage WL patterns over time were identified in 7,121 patients who attended a physician lead multi‐disciplinary clinical lifestyle weight management that predominantly focused on education and diet counselling. Resultant health differences were examined.ResultsPatients had 3.2 ± 6.3%WL with 35% of patients achieving and maintaining a 5%WL. Half of these patients achieved the 5%WL within 6 months, while the other half had a more gradual approach. Another 10% achieved 5%WL, but regained weight after 6 months. There were seven distinct WL patterns identified: LargeWL (Mean WL: 21.2 ± 8.1%; Probability of group membership (PGM): 2.4%), ModerateWL (15.1 ± 5.1%WL; 5.4%PGM), SlowWL (6.7 ± 3.2%WL; 20.1%PGM) and MinimalWL (2.4 ± 2.2%WL; 34.6%PGM), WL Regain (9.4 ± 3.5%WL; 8.2%PGM), Weight Stable (1.2 ± 3.2%WL; 28.5%PGM) and Weight Gain (18.4 ± 11.2%WG; 0.8%PGM) groups. Improvements in blood pressure, lipids and glucose were generally related to the magnitude of WL achieved more than the pattern or speed of WL.ConclusionsThere are large differences in the absolute WL attained and the pattern of WL during a publicly funded weight management program. Changes in clinical health markers appear to be more strongly related with the absolute WL attained as opposed to patterns of weight change. © 2016 The Authors. Obesity Science & Practice published by John Wiley & Sons Ltd, World Obesity and The Obesity Society.