Red pepper seed water extract suppresses high-fat diet-induced obesity in C57BL/6 mice

Abstract

In this study, the protective effect of red pepper seed water extract (RPS) against the obesity in high fat diet (HFD)-fed mice was investigated (HFD control group, and HFD group treated with 100 or 200 mg/kg body weight of RPS for 13 weeks). The application of RPS partially reversed the HFD-induced increases in body weight and adipose tissue weight. The patterns of the adipose tissue weights were parallel to the patterns of fat area, as measured in DXA procedure. In the adipose tissue, RPS suppressed the expression of adipogenic transcription factors and adipose marker genes. AMP-activated protein kinase activation was observed in the adipose tissue by RPS treatment. In addition, RPS improved high homeostasis model assessment of insulin resistance and hyperlipidemia in HFD fed mice. These findings suggest that RPS can be used as a potential therapeutic substance for reducing body fat and obesity related diseases.

Red Pepper (Capsicum annuum L.) Seed Extract Improves Glycemic Control by Inhibiting Hepatic Gluconeogenesis via Phosphorylation of FOXO1 and AMPK in Obese Diabetic db/db Mice

“…Our findings are contrary to expectations, because a recent study reported that RPSE hindered the increase in body weight and adiposity in HFD-induced obese mice by the inhibition of adipogenesis (via C/EBPα and PPARγ) of exogenous fat into white adipose tissues (WAT) [20]. The differences in these results are attributed to the fact that pathologic mechanisms of ObD mice, which are accompanied by leptin and insulin resistance, are not solely identical to those of the high fat-induced obesity model.…”

“…Then, mice were randomly divided into four groups: (1) heterozygote db/+, (2) db/db negative control (CTL), (3) RPSE (200 mg/kg bw), or (4) metformin (150 mg/kg bw). The experimental dose was decided based on a previous study, in which 200 mg/kg bw of RPSE suppressed HFD-induced obesity in mice [20]. Metformin was used as a comparative control (provided by Withus pharmaceutical, Anseong, Korea).…”

“…Treatment with 5 mg/dL capsaicin for 4 weeks improved postprandial hyperglycemia and hyperinsulinemia in a randomized double-blind trial on gestational diabetes mellitus subjects [35]. Studies on capsaicin-independent anti-diabetes effects have recently reported that icariside E 5 -rich RPSE (100 and 200 mg/kg bw) reduced fasting glucose levels, insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) in high-fat-induced obesity mice [18,20]. Our findings additionally highlight the anti-diabetic potency of RPSE in the ObD model, which has yet to be reported [20].…”

Effect of Soybean and Soybean Koji on Obesity and Dyslipidemia in Rats Fed a High-Fat Diet: A Comparative Study

“…Therefore, dietary and lifestyle interventions are fundamental to countering obesity. As a result, natural materials, including red pepper [ 17 ], ginger [ 18 ], and green tea [ 19 ], which have been reported to possess anti-obesity effects, are preferred for preventing obesity [ 20 ].…”

DHA‐enriched phosphatidylserine ameliorates high‐fat diet‐induced kidney injury in mice possibly by regulating TLR4/NF‐κB and AMPK pathways

“…The remaining eight mice fed with a standard diet were regarded as the LFD group (LFD, n = 8). The composition of the standard diet and HFD is the same as in the previous studies (H. J. Kim et al., 2020). The HFD mice models were stochastic averaging classified into three groups: the HFD group without DHA‐PS treatment (HFD, n = 8), the HFD group treated with 20 mg/kg/d of DHA‐PS (20 DHA‐PS, n = 8), and the HFD group treated with 40 mg/kg/d of DHA‐PS (40 DHA‐PS, n = 8).…”