Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice

Noratto, Giuliana; Chew, Boon P.; Atienza, Liezl

doi:10.1016/j.foodchem.2017.01.097

Cited by 88 publications

(52 citation statements)

References 37 publications

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“…Ot was reported that isocaloric diets containing freeze-dried raspberries, improved antioxidant status by 5.3% and lessened plasma interleukin (OL)-6 content (0.3-fold of control isocaloric diets, p<0.1). Raspberry intake at this dose led to no difference in BMO, APO, and weights of heart, liver, or kidney between the raspberry and control group, which were similar to the results of the RLP group, but there were no testes data (Noratto et al, 2017). Raspberry juice and puree concentrates and the combination of EA+raspberry ketone (RK) decreased weight gain and obesity in high-fat-fed mice (Luo et al, 2016).…”

Section: Mice Endurance Capacity and Weight Changes In Mice Fed Extractssupporting

confidence: 64%

Determination of active compounds in raspberry leaf extracts and the effects of extract intake on mice

et al. 2020

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Twelve typical polyphenols in raspberry leaf powder (RLP), raspberry leaf extract 1 (RLE) and raspberry leaf extract 2 (RLE-H) were analyzed by HPLC-MS. The sum of their contents in three samples were in the following order: RLP (8.6 mg g -1 ) < RLE (35.0 mg g -1 ) < RLE-H (44.1 mg g -1 ). Ellagic acid and quercetin-3-D-glucuronide were the principal compounds in the samples and accounted for more than 75% of the sum content. A gelled mixture of RLE, pectin, and sodium alginate administrated to mice via gavage resulted in reduced weight gain and adiposity percentage, increased teste percentage, prolonged exhaustion time, furthermore alleviated intestinal flatulence possibly induced by RLE or RLE-H alone. These results could help in making rational use of this high polyphenol extract from raspberry leaves.

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Section: Mice Endurance Capacity and Weight Changes In Mice Fed Extractssupporting

confidence: 64%

Determination of active compounds in raspberry leaf extracts and the effects of extract intake on mice

et al. 2020

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“…Dietary fibers reduce absorption of dietary lipids and ameliorate glycemia in obese rats . Recent studies reported that dietary RB protects against obesity related oxidative stress in obese diabetic (db/db) mice; RB juice or RB puree concentrate mitigated body weight gain in HFD‐mice . We recently showed that dietary RB improved glucose and lipid homeostasis in HFD‐mice .…”

Section: Discussionmentioning

confidence: 99%

“…Raspberry (RB) contains high levels of polyphenols, dietary fibers and vitamins, exhibiting anti‐oxidative and anti‐inflammatory effects . Recent studies indicated that dietary RB juice or puree concentrate suppresses obesity; the whole RB intake increases antioxidant defenses and protects against obesity related oxidative stress . However, the mechanism of RB exerts anti‐obesity effects remains to be defined.…”

Section: Introductionmentioning

confidence: 99%

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Raspberry Supplementation Improves Insulin Signaling and Promotes Brown‐Like Adipocyte Development in White Adipose Tissue of Obese Mice

Xing

Kang

et al. 2018

Molecular Nutrition Food Res

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“…Red raspberries are fruits containing bioactive polyphenols such as ellagitannins and anthocyanins [11] that have a potential to modify the body metabolism, therefore modulating health in patients suffering with weight disorders [12]. The health benefits associated with these substances are various and relate in part to the inhibition of digestive enzymes [13], a decrease of oxidative stress [14], and a change in the gut microbiota [15]. Ellagitannins from red raspberry exert cytotoxic effects against human colon adenocarcinoma in vitro [16] and reduce secondary bile acids in rats fed a high-fat diet [17].…”

Section: Introductionmentioning

confidence: 99%

Dietary Supplementation with Raspberry Extracts Modifies the Fecal Microbiota in Obese Diabetic db/db Mice

García-Mazcorro¹,

Pedreschi

Chew

et al. 2018

Journal of Microbiology and Biotechnology

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Raspberries are polyphenol-rich fruits with the potential to reduce the severity of the clinical signs associated with obesity, a phenomenon that may be related to changes in the gut microbiota. The aim of this study was to investigate the effect of raspberry supplementation on the fecal microbiota using an in vivo model of obesity. Obese diabetic db/db mice were used in this study and assigned to two experimental groups (with and without raspberry supplementation). Fecal samples were collected at the end of the supplementation period (8 weeks) and used for bacterial 16S rRNA gene profiling using a MiSeq instrument (Illumina). QIIME 1.8 was used to analyze the 16S data. Raspberry supplementation was associated with an increased abundance of Lachnospiraceae (p = 0.009), a very important group for gut health, and decreased abundances of Lactobacillus, Odoribacter, and the fiber degrader S24-7 family as well as unknown groups of Bacteroidales and Enterobacteriaceae (p < 0.05). These changes were enough to clearly differentiate bacterial communities accordingly to treatment, based on the analysis of UniFrac distance metrics. However, a predictive approach of functional profiles showed no difference between the treatment groups. Fecal metabolomic analysis provided critical information regarding the raspberry-supplemented group, whose relatively higher phytosterol concentrations may be relevant for the host health, considering the proven health benefits of these phytochemicals. Further studies are needed to investigate whether the observed differences in microbial communities (e.g., Lachnospiraceae) or metabolites relate to clinically significant differences that can prompt the use of raspberry extracts to help patients with obesity.

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Red raspberry (Rubus idaeus L.) intake decreases oxidative stress in obese diabetic (db/db) mice

Cited by 88 publications

References 37 publications

Determination of active compounds in raspberry leaf extracts and the effects of extract intake on mice

Determination of active compounds in raspberry leaf extracts and the effects of extract intake on mice

Raspberry Supplementation Improves Insulin Signaling and Promotes Brown‐Like Adipocyte Development in White Adipose Tissue of Obese Mice

Dietary Supplementation with Raspberry Extracts Modifies the Fecal Microbiota in Obese Diabetic db/db Mice

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