Red reflex test screening for neonates: A systematic review and meta analysis

Jameel, Patel Zeeshan; Taksande, Amar; Meshram, Revat

doi:10.4103/ijo.ijo_3632_20

Cited by 18 publications

(17 citation statements)

References 25 publications

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“…Our review suggests that red reflex testing is reasonably sensitive (67%, 95% CI = 9%-99%) for clinically significant anterior segment conditions, which is acceptable for screening purposes in most settings. However, we identified only one high-quality study [24] We identified two other DTA reviews of red reflex testing in newborns, which report lower sensitivities (23% and 17.5%) [34,35]. The high specificities reported (98% and 97.5%) are comparable to the study we report.…”

Section: Discussionsupporting

confidence: 58%

Universal newborn eye screening: a systematic review of the literature and review of international guidelines

et al. 2022

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Background This systematic review assessed the effectiveness of universal screening for newborn eye abnormalities compared with no screening in improving infant vision and health outcomes. MethodsWe searched CENTRAL (Cochrane Library), MEDLINE, Embase, Global Health, Global Index Medicus, clinical trials databases, and bibliographies of relevant articles. We included randomized and observational studies of all newborns, regardless of illness or risk factors, that compared universal screening for any eye abnormality by eight weeks of age with no universal screening. Two authors independently selected studies, extracted data, and evaluated the risk of bias. We used GRADE to assess the certainty of evidence. We also reviewed available recommendations on newborn eye screening. ResultsFourteen studies were identified but only three compared universal red reflex screening with no screening. Findings suggest that universal red reflex testing in maternity wards (MWs) may increase the number of newborns with congenital cataracts referred for eye care from MWs or well-baby clinics (WBCs) in the first year of life (risk ratio (RR) = 9.83, 95% confidence interval (CI) = 1.36-71.20; low certainty evidence). However, the effect of screening in WBC is uncertain (RR = 6.62, 95% CI = 0.87-50.09). The effect of MW or WBC screening on referral from any health care facility (MWs, WBCs, paediatrician clinic, other) in the first year is uncertain (MW screening: RR = 1.22, 95% CI = 0.63-2.39; WBC screening: RR = 0.97, 95% CI = 0.46-2.05). However, referral or surgery by 6 weeks of age may be higher with universal MW screening (early referral: RR = 4.61, 95% CI = 1.12-19.01; early surgery: RR = 8.23, 95% CI = 1.13-59.80; low certainty evidence). The effect of WBC screening on early referral and surgery is uncertain (early referral: RR = 1.98, 95% CI = 0.43-9.19; early surgery: RR = 3.97, 95% CI = 0.50-31.33; very low certainty evidence). Universal red reflex testing may increase clinical conjunctivitis (OR = 1.22, 95% CI = 1.01-1.47; low certainty evidence) but the effect on confirmed bacterial conjunctivitis is uncertain (OR = 1.20, 95% CI = 0.76-1.90; very low-certainty evidence). Nine guidelines recommended universal newborn eye screening using red reflex testing.Conclusions Evidence supports the role of red reflex testing shortly after birth to increase early identification, referral, and surgery for congenital cataracts. Registration PROSPERO (reference CRD42020180524).In 2020, 1.44 million children aged 0-14 years were estimated to be blind or severely visually impaired [1]. Most blind children are either born blind from congenital conditions or become blind before the age of 5 years from acquired conditions [2,3].

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Section: Discussionsupporting

confidence: 58%

Universal newborn eye screening: a systematic review of the literature and review of international guidelines

et al. 2022

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“…[ 6 ] In a large meta-analysis published in this issue of Indian Journal of Ophthalmology, the authors seem to confirm the low sensitivity (23%) and high specificity (98%) of the red reflex test but show that the test is excellent for the detection of anterior segment anomalies (99.2%) as compared to disorders of the posterior segment (14.1%). [ 7 ]…”

Section: Is Red Reflex Test Reliable?mentioning

confidence: 99%

The Red Reflex Test - Shadow conceals, light reveals

Honavar

2021

Indian Journal of Ophthalmology

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“…The patients' general health and satisfaction were assessed using the Short Form Health Survey-36 and the Global Rating of Change score, respectively. Before therapy, 3, 6, and 24 weeks after treatment, the variations (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) in dependent factors were investigated. In every parameter that measures success.…”

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confidence: 99%

Matrix Rhythm Therapy For Shoulder Joint and Leprosy – A Review Article

Sheikh¹,

Telang²

2022

Journal of Pharmaceutical Negative Results

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The Matrix Rhythm concept is founded on the premise that all cellular actions, whether preventive, therapeutic, regenerative, or destructive, operate largely through the cell's environment. The frequency of pulsation in muscle cells is 8-12 Hertz. Outside of the 8-12 Hertz range, muscle pulsation frequency is linked to aches, muscle tension, and other health issues. Variations in pulse frequency and the logistics of the life process at the cellular level are linked to changes in muscle flexibility and plasticity. Specific vibrations in skeletal muscles and the nervous system are activated and rebalanced by the MRT. The MRT generates an oscillating rhythm that increases lymphatic venous perfusion of the extracellular space, in which the anti-edematous benefits occur. We reviewed the Matrix Rhythm Therapy procedures in treating various pathological disorders in this research.Matrix rhythm therapy is useful in treating complaints such as enhancing Range of motion, increase in muscle strength and lowering in pain, according to the result of this research. In terms of physical health, functional outcomes, and satisfaction, matrix rhythm therapy delivers long- term benefits for those with frozen shoulder and leprosy.

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Red reflex test screening for neonates: A systematic review and meta analysis

Cited by 18 publications

References 25 publications

Universal newborn eye screening: a systematic review of the literature and review of international guidelines

Universal newborn eye screening: a systematic review of the literature and review of international guidelines

The Red Reflex Test - Shadow conceals, light reveals

Matrix Rhythm Therapy For Shoulder Joint and Leprosy – A Review Article

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