Red Wine Extract Prevents Oxidative Stress and Inflammation in ARPE-19 Retinal Cells

Cornebise, Clarisse; Perus, Maude; Hermetet, François; Valls, Josep; Richard, Tristan; Aires, Virginie; Delmas, Dominique

doi:10.3390/cells12101408

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…The antioxidant activity is expressed through free radical scavenging and through the upregulation of Nrf2, which in turn induces antioxidant gene expression [121]. Regarding their anti-inflammatory activities, a series of mechanisms have been proposed, such as switching off the NF-κB pathway [122], blocking oxysterolrelated NOX1 induction [123], suppression of NLRP3 inflammasome activation [124], suppression of the JAK/STAT inflammatory pathway and modulation of Nrf2 activity [125], as well as decrease in IL-1β, IL-6 and IL-8 secretion [126,127]. Finally, the capacity of red wine to inhibit thrombin, ADP-and PAF-induced platelet aggregation has been reported [128][129][130][131][132][133] and attributed to ethanol and polyphenols, particularly quercetin, tyrosol and trans-resveratrol [132,133].…”

Section: Functional Properties Of Winementioning

confidence: 99%

Fermented Beverages Revisited: From Terroir to Customized Functional Products

Paramithiotis,

Patra,

Kotseridis

et al. 2024

Fermentation

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Fermented beverages have been a constant companion of humans throughout their history. A wide range of products have been developed with time, depending on the availability of raw materials and ambient conditions. Their differentiation was based on the specific characteristics of each product, resulting from the cultivation of different varieties and the variability of environmental conditions and agricultural practices, collectively described by the term ‘terroir’ that was developed in winemaking. The health benefits that have been associated with their consumption, which include the control of blood pressure and glycemic control, along with immunomodulatory, hypocholesterolemic, hepatoprotective, and antiproliferative activities, directed their re-discovery that occurred over the last few decades. Thus, the dynamics of the microbial communities of fermented beverages during fermentation and storage have been thoroughly assessed. The functional potential of fermented beverages has been attributed to the chemical composition of the raw materials and the bioconversions that take place during fermentation and storage, due to the metabolic capacity of the driving microbiota. Thus, the proper combination of raw materials with certain microorganisms may allow for the modulation of the organoleptic properties, as well as enrichment with specific functional ingredients, enabling targeted nutritional interventions. This plasticity of fermented beverages is their great advantage that offers limitless capabilities. The present article aims to critically summarize and present the current knowledge on the microbiota and functional potential of fermented beverages and highlight the great potential of these products.

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Section: Functional Properties Of Winementioning

confidence: 99%

Fermented Beverages Revisited: From Terroir to Customized Functional Products

Paramithiotis,

Patra,

Kotseridis

et al. 2024

Fermentation

View full text Add to dashboard Cite

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Gallic Acid-Encapsulated PAMAM Dendrimers as an Antioxidant Delivery System for Controlled Release and Reduced Cytotoxicity against ARPE-19 Cells

Sripunya,

Chittasupho,

Mangmool

et al. 2024

Bioconjugate Chem.

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Poly(amidoamine) (PAMAM) dendrimers have gained significant attention in various research fields, particularly in medicinal compound delivery. Their versatility lies in their ability to conjugate with functional molecules on their surfaces and encapsulate small molecules, making them suitable for diverse applications. Gallic acid is a potent antioxidant compound that has garnered considerable interest in recent years. Our research aims to investigate if the gallic acid-encapsulated PAMAM dendrimer generations 4 (G4(OH)-Ga) and 5 (G5(OH)-Ga) could enhance radical scavenging, which could potentially slow down the progression of age-related macular degeneration (AMD). Encapsulation of gallic acid in PAMAM dendrimers is a feasible alternative to prevent its degradation and toxicity. In vitro investigation of antioxidant activity was carried out using the DPPH and ABTS radical scavenging assays, as well as the FRAP assay. The IC 50 values for DPPH and ABTS assays were determined through nonlinear dose−response curves, correlating the inhibition percentage with the concentration (μg/mL) of the sample and the concentration (μM) of gallic acid within each sample. G4(OH)-Ga and G5(OH)-Ga possess significant antioxidant activities as determined by the DPPH, ABTS, and FRAP assays. Moreover, gallic acid-encapsulated PAMAM dendrimers inhibit H 2 O 2 -induced reactive oxygen species (ROS) production in the human retinal pigment epithelium ARPE-19 cells, thereby improving antioxidant characteristics and potentially retarding AMD progression caused by ROS. In an evaluation of cell viability of ARPE-19 cells using the MTT assay, G4(OH)-Ga was found to reduce cytotoxic effects on ARPE-19 cells.

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Investigation into the Neuroprotective and Therapeutic Potential of Plant-Derived Chk2 Inhibitors

Kisielewska,

Filipski,

Sebastianka

et al. 2024

IJMS

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Nature provides us with a rich source of compounds with a wide range of applications, including the creation of innovative drugs. Despite advancements in chemically synthesized therapeutics, natural compounds are increasingly significant, especially in cancer treatment, a leading cause of death globally. One promising approach involves the use of natural inhibitors of checkpoint kinase 2 (Chk2), a critical regulator of DNA repair, cell cycle arrest, and apoptosis. Chk2’s activation in response to DNA damage can lead to apoptosis or DNA repair, influencing glycolysis and mitochondrial function. In cancer therapy, inhibiting Chk2 can disrupt DNA repair and cell cycle progression, promoting cancer cell death and enhancing the efficacy of radiotherapy and chemotherapy. Additionally, Chk2 inhibitors can safeguard non-cancerous cells during these treatments by inhibiting p53-dependent apoptosis. Beyond oncology, Chk2 inhibition shows potential in treating hepatitis C virus (HCV) infections, as the virus relies on Chk2 for RNA replication in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), in which DNA damage plays a crucial role. Plant-derived Chk2 inhibitors, such as artemetin, rhamnetin, and curcumin, offer a promising future for treating various diseases with potentially milder side effects and broader metabolic impacts compared to conventional therapies. The review aims to underscore the immense potential of natural Chk2 inhibitors in various therapeutic contexts, particularly in oncology and the treatment of other diseases involving DNA damage and repair mechanisms. These natural Chk2 inhibitors hold significant promise for revolutionizing the landscape of cancer treatment and other diseases. Further research into these compounds could lead to the development of innovative therapies that offer hope for the future with fewer side effects and enhanced efficacy.

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Red Wine Extract Prevents Oxidative Stress and Inflammation in ARPE-19 Retinal Cells

Cited by 3 publications

References 74 publications

Fermented Beverages Revisited: From Terroir to Customized Functional Products

Fermented Beverages Revisited: From Terroir to Customized Functional Products

Gallic Acid-Encapsulated PAMAM Dendrimers as an Antioxidant Delivery System for Controlled Release and Reduced Cytotoxicity against ARPE-19 Cells

Investigation into the Neuroprotective and Therapeutic Potential of Plant-Derived Chk2 Inhibitors

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