Red Wine Inhibits Monocyte Chemotactic Protein-1 Expression and Modestly Reduces Neointimal Hyperplasia After Balloon Injury in Cholesterol-Fed Rabbits

Feng, An‐Ning; Chen, Yuh‐Lien; Chen, Ya-Ting; Ding, Yaw-Zon; Lin, Shing‐Jong

doi:10.1161/01.cir.100.22.2254

Cited by 72 publications

(44 citation statements)

References 32 publications

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“…However, given the wealth of scientific data implicating MCP-1 early in the development of atherosclerosis and the close associations observed between 32 hormone replacement, 14 and even consumption of red wine. 33 In summary, MCP-1 is associated with traditional risk factors for atherosclerosis, but the prognostic value of this marker appears to be independent of these risk factors; furthermore, MCP-1 levels appear to be modifiable with currently available preventive therapies. These observations suggest that MCP-1 may eventually prove to be useful as a surrogate biomarker in patients with or at risk for atherosclerosis and its complications.…”

Section: Discussionmentioning

confidence: 96%

Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes

et al. 2003

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Background-Monocyte chemoattractant protein-1 (MCP-1) is a chemokine responsible for the recruitment of monocytes to sites of inflammation. MCP-1 appears to play a critical role at multiple stages in atherosclerosis, including the initiation of the fatty streak, promotion of plaque instability, and remodeling after myocardial infarction. After adjustment for differences in baseline characteristics, ECG changes, troponin I, and C-reactive protein, an MCP-1 level Ͼ75th percentile (corresponding to the 90th percentile in the healthy volunteers) was associated with an increased risk of death or myocardial infarction through 10 months of follow-up (adjusted hazard ratio, 1.53; 95% CI, 1.09 to 2.14; Pϭ0.01). Conclusions-In a large cohort of patients with acute coronary syndromes, an elevated baseline level of MCP-1 was associated both with traditional risk factors for atherosclerosis as well as an increased risk for death or myocardial infarction, independent of baseline variables. Because it appears to play a crucial role at multiple stages of atherosclerosis, MCP-1 is attractive as a surrogate biomarker and merits further study as a potential therapeutic target.

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Section: Discussionmentioning

confidence: 96%

Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes

et al. 2003

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“…In experimental studies, furthermore, moderate ethanol intake reduces blood pressure and subsequent renal vascular injury in spontaneously hypertensive rats (36). In a rabbit model of vascular balloon injury, moderate alcohol intake has been found to limit neointimal hyperplasia in a pressure-independent manner involving less local chemokine expression (10). To extend these findings to renal disease, the present study employed the rat model of anti-thy1 glomerulonephritis to test in vivo the hypothesis that moderate alcohol consumption protects from acute and chronic renal matrix accumulation and renal insufficiency.…”

Section: Discussionmentioning

confidence: 98%

Moderate alcohol intake has no impact on acute and chronic progressive anti-thy1 glomerulonephritis

Peters

Martini

Woydt

et al. 2003

American Journal of Physiology-Renal Physiology

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Moderate alcohol consumption has shown beneficial effects in experimental and human cardiovascular disease. With the use of rat models of acute and chronic progressive anti-thy1 glomerulonephritis (GN), we tested the hypothesis that moderate alcohol intake is protective in renal fibrotic disease. In acute anti-thy1 GN, untreated nephritic rats showed marked mesangial cell lysis and induced nitric oxide production at day 1 and high proteinuria, glomerular matrix accumulation, and transforming growth factor (TGF)-β1, fibronectin, and plasminogen activator inhibitor (PAI)-1 expression at day 7 after disease induction, respectively. In animals 15 wk after induction of chronic progressive anti-thy1 GN, disease was characterized by significantly reduced renal function, persisting albuminuria as well as increased glomerular and tubulointerstitial matrix expansion, TGF-β1, fibronectin, and PAI-1 protein expression. In both anti-thy1 GN models, an ethanol intake of ∼2 ml per day and animal was achieved, however, disease severity was not significantly altered by moderate alcohol consumption in any of the protocols. In conclusion, moderate alcohol intake does not influence renal matrix protein production and accumulation in acute and chronic progressive anti-thy1 glomerulofibrosis. The study suggests that, in contrast to cardiovascular disorders, moderate alcohol consumption might not provide specific protection in renal fibrotic disease.

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“…Apoprotein E (Apo E)-deficient mice also showed reduced atherosclerosis progression when fed RW (14). RW also causes monocyte chemotactic protein-1 expression blockade and reduced neointimal hyperplasia after balloon injury in rabbits (15), inhibition of smooth muscle cell proliferation and of cyclin A expression (16), as well as inhibition of the plateletderived growth factor receptor by RW flavonoids in cultured smooth muscle cells (17) -all of them factors contributing to atherogenesis.…”

Section: Introductionmentioning

confidence: 99%

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

Coimbra

Lage

Brandizzi

et al. 2005

Braz J Med Biol Res

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Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.

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Red Wine Inhibits Monocyte Chemotactic Protein-1 Expression and Modestly Reduces Neointimal Hyperplasia After Balloon Injury in Cholesterol-Fed Rabbits

Cited by 72 publications

References 32 publications

Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes

Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes

Moderate alcohol intake has no impact on acute and chronic progressive anti-thy1 glomerulonephritis

The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients

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