Red yeast rice dietary intervention reduces oxidative stress-related inflammation and improves intestinal microbiota

Huang, Ya‐Ping; Li, Ping; Li, Zhengang; Zhu, Dongdong; Fan, Yufei; Wang, Xiaoyi; Zhao, Chumin; Jiao, Jingbo; Du, Xinjun; Wang, Shuo

doi:10.1039/d1fo03776e

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…Currently, several health impacts associated with the consumption of red yeast rice have been proven, including anti-inflammatory, anti-obesity, anti-diabetic, and anti-osteoporotic effects. These health effects have been demonstrated in vitro, in vivo, and in clinical trials by Huang et al [37] and Rahmani et al [38]. It has also been reported that red yeast rice supplementation decreases total cholesterol, triglycerides, and low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol levels [38].…”

Section: Health Benefits Of Red Rice Productsmentioning

confidence: 85%

A Review of the Influence of Genotype, Environment, and Food Processing on the Bioactive Compound Profile of Red Rice (Oryza sativa L.)

Rodrigues,

Cañizares,

Meza

et al. 2024

Agronomy

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Red rice has achieved a lot of visibility due to its greater amounts of bioactive compounds compared to traditional white rice. The increased recognition of red rice by the industry is a consequence of the expansion of its study in the field of research. The red color of its grains is characteristic of the presence of proanthocyanidins, which is associated with health benefits such as reducing the risk of chronic diseases. In addition, red rice is gluten-free and hypoallergenic, which makes it suitable for celiac or gluten-intolerant patients. However, the contents of phytochemicals can vary with the influence of the adaptability of genotypes to the environment, cultivation practices, abiotic stresses, and industrial processing. In this scenario, one of the challenges is to increase the diversity of red rice products while having a minimum impact on the content of bioactive compounds, mainly flavonoids and phenolic acids. In this review, a complete overview of the importance of pigmented red rice is presented, including the effects of different genotypes, the growth environment, and industrial processing on the bioactive compounds, mainly flavonoids and phenolic acids, in red rice, and the health benefits of its products are described. Studies cited in this review article were found by searching through the Web of Science database from 2013 to 2023. After a detailed and up-to-date search, 36 studies were included in this review article.

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Section: Health Benefits Of Red Rice Productsmentioning

confidence: 85%

A Review of the Influence of Genotype, Environment, and Food Processing on the Bioactive Compound Profile of Red Rice (Oryza sativa L.)

Rodrigues,

Cañizares,

Meza

et al. 2024

Agronomy

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“…43 Lachospiraceae and Rikenellaceae could alleviate oxidative damage by clearing ROS, and Rikenellaceae could also inhibit inflammation by stimulating T cell differentiation. 44 In our study, puerarin treatment increased the abundance of Lactobacillaceae, Lachospiraceae, and Rikenellaceae, which is beneficial to alleviate oxidative stress and inflammation, thus further delaying aging. Meanwhile, puerarin could significantly increase the abundance of Lactobacillus, Bif idobacterium, and Rikenella in chronic inflammation response mice.…”

Section: Discussionmentioning

confidence: 95%

Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway

Liu,

Hu,

Zhang

et al. 2024

J. Agric. Food Chem.

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Mammary gland aging is one of the most important problems faced by humans and animals. How to delay mammary gland aging is particularly important. Puerarin is a kind of isoflavone substance extracted from Pueraria lobata, which has antiinflammatory, antioxidant, and other pharmacological effects. However, the role of puerarin in delaying lipopolysaccharide (LPS)induced mammary gland aging and its underlying mechanism remains unclear. On the one hand, we found that puerarin could significantly downregulate the expression of senescence-associated secretory phenotype (SASP) and age-related indicators (SA-β-gal, p53, p21, p16) in mammary glands of mice. In addition, puerarin mainly inhibited the p38MAPK signaling pathway to repair mitochondrial damage and delay mammary gland aging. On the other hand, puerarin could also delay the cellular senescence of mice mammary epithelial cells (mMECs) by targeting gut microbiota and promoting the secretion of gut microbiota metabolites. In conclusion, puerarin could not only directly act on the mMECs but also regulate the gut microbiota, thus, playing a role in delaying the aging of the mammary gland. Based on the above findings, we have discovered a new pathway for puerarin to delay mammary gland aging.

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“…The expression of these inflammation‐associated proteins and cytokines might be influenced by food components. For example, the expression of pro‐inflammatory cytokines in the blood was reported to be reduced by the red rice diet (Huang et al., 2022). In addition, petunidin‐3,5‐ O ‐diglucoside (prepared from LR anthocyanins) was shown to protect Neuro‐2 cells (mouse brain neuroma cells) from oxidative stress and inflammatory responses induced by chronic granulocytic leukemia through inhibiting the ROS‐NF‐κB signaling pathway (Chen et al., 2022).…”

Section: Discussionmentioning

confidence: 99%

Protective effect and mechanism of Lycium ruthenicum Murray anthocyanins against retinal damage induced by blue light exposure

Li,

Sun

et al. 2024

Journal of Food Science

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Lycium ruthenicum Murray (LR) is a medicine and edible plant in Northwest China, and L. ruthenicum Murray anthocyanins (LRA) are green antioxidants with various pharmacological activities, such as antioxidant and anti‐inflammatory activities. However, the protective effect and mechanism of LRA against retinal damage induced by blue light exposure are poorly understood. This study explored the protective effects and potential mechanisms of LRA on retinal damage induced by blue light exposure in vitro and in vivo. The results showed that LRA could ameliorate oxidative stress injury by activating the antioxidant stress nuclear factor‐related factor 2 pathway, promoting the expression of phase II detoxification enzymes (HO‐1, NQO1) and endogenous antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and reducing reactive oxygen species and malondialdehyde levels. Additionally, LRA could inhibit inflammatory response by decreasing the expression of blue light exposure‐induced nuclear factor‐κB (NF‐κB) pathway‐related proteins (NF‐κB and p‐IκBα), as well as interleukin (IL)‐6, tumor necrosis factor‐α, IL‐1β pro‐inflammatory factors and pro‐inflammatory chemokine VEGF, and increasing the expression of anti‐inflammatory factor IL‐10. Furthermore, LRA could ameliorate oxidative stress‐induced apoptosis by upregulating Bcl‐2 and downregulating Bax and Caspase‐3 protein expression. All these results indicate that LRA can be used as an antioxidant dietary supplement for the treatment or prevention of retinal diseases.

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Red yeast rice dietary intervention reduces oxidative stress-related inflammation and improves intestinal microbiota

Abstract: RYR dietary intervention could significantly improve the cognitive ability of mice, reduce oxidative stress and NF-κB-mediated inflammation, slowing down apoptosis and regulating the intestinal flora in mice.

Cited by 10 publications

References 42 publications

A Review of the Influence of Genotype, Environment, and Food Processing on the Bioactive Compound Profile of Red Rice (Oryza sativa L.)

A Review of the Influence of Genotype, Environment, and Food Processing on the Bioactive Compound Profile of Red Rice (Oryza sativa L.)

Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway

Protective effect and mechanism of Lycium ruthenicum Murray anthocyanins against retinal damage induced by blue light exposure

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