2013
DOI: 10.1007/s00726-013-1541-x
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Redefining an epitope of a malaria vaccine candidate, with antibodies against the N-terminal MSA-2 antigen of Plasmodium harboring non-natural peptide bonds

Abstract: The aim of obtaining novel vaccine candidates against malaria and other transmissible diseases can be partly based on selecting non-polymorphic peptides from relevant antigens of pathogens, which have to be then precisely modified for inducing a protective immunity against the disease. Bearing in mind the high degree of the MSA-221–40 peptide primary structure’s genetic conservation among malaria species, and its crucial role in the high RBC binding ability of Plasmodium falciparum (the main agent causing mala… Show more

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Cited by 4 publications
(11 citation statements)
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“…Similarly, CD profile for the L-native sequence compared with that of the Retro-inverso analogue (green line), behave as mirror images of each other bearing in mind that both were made with only l-amino acids, but having opposite peptide backbone orientation. [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] peptide. The native sequence is represented in capital letters for l-amino acids, D-enantiomer represented by lowercase letters purple highlighted, Retro-sequence is constituted by d-amino acids in lowercase letters blue highlighted and the so-named Retro-inverso peptidomimetic is confirmed by l-amino acids green highlighted.…”
Section: New Modified Vaccine Components Containing Non-natural Elemementioning
confidence: 99%
See 4 more Smart Citations
“…Similarly, CD profile for the L-native sequence compared with that of the Retro-inverso analogue (green line), behave as mirror images of each other bearing in mind that both were made with only l-amino acids, but having opposite peptide backbone orientation. [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] peptide. The native sequence is represented in capital letters for l-amino acids, D-enantiomer represented by lowercase letters purple highlighted, Retro-sequence is constituted by d-amino acids in lowercase letters blue highlighted and the so-named Retro-inverso peptidomimetic is confirmed by l-amino acids green highlighted.…”
Section: New Modified Vaccine Components Containing Non-natural Elemementioning
confidence: 99%
“…The native sequence is represented in capital letters for l-amino acids, D-enantiomer represented by lowercase letters purple highlighted, Retro-sequence is constituted by d-amino acids in lowercase letters blue highlighted and the so-named Retro-inverso peptidomimetic is confirmed by l-amino acids green highlighted. (B) Circular dichroism secondary structure patterns for PfMSP1 [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] peptido-mimetics. Used color code was black line for the native sequence, purple for its D-enantiomer, blue line for the Retro-analogue and green line for the Retroinverso peptido-mimetic.…”
Section: New Modified Vaccine Components Containing Non-natural Elemementioning
confidence: 99%
See 3 more Smart Citations