Redefining environmental exposure for disease etiology

Rappaport, Stephen M.

doi:10.1038/s41540-018-0065-0

Cited by 43 publications

(40 citation statements)

References 67 publications

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“…In other words: The exposome has been advocated as a key to cumulative risk assessment (Smith et al 2015). Recently, the concept has been redefined by Rappaport (2018): "The blood exposome consists of chemicals derived from both endogenous and exogenous sources. Endogenous chemicals are represented by the human proteome and metabolome, which establish homeostatic networks of functional molecules.…”

Section: The Exposome and Exposomicsmentioning

confidence: 99%

Role of Damage-Associated Molecular Patterns in Light of Modern Environmental Research: A Tautological Approach

Land

2020

Int J Environ Res

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Two prominent models emerged as a result of intense interdisciplinary discussions on the environmental health paradigm, called the "exposome" concept and the "adverse outcome pathway" (AOP) concept that links a molecular initiating event to the adverse outcome via key events. Here, evidence is discussed, suggesting that environmental stress/injury-induced damageassociated molecular patterns (DAMPs) may operate as an essential integrating element of both environmental health research paradigms. DAMP-promoted controlled/uncontrolled innate/adaptive immune responses reflect the key events of the AOP concept. The whole process starting from exposure to a distinct environmental stress/injury-associated with the presence/ emission of DAMPs-up to the manifestation of a disease may be regarded as an exposome. Clinical examples of such a scenario are briefly sketched, in particular, a model in relation to the emerging COVID-19 pandemic, where the interaction of noninfectious environmental factors (e.g., particulate matter) and infectious factors (SARS CoV-2) may promote SARS case fatality via superimposition of both exogenous and endogenous DAMPs. Article Highlights • This review is devoted to the first scientific attempt to integrate DAMP-controlled innate immune inflammatory and adaptive immune defense responses as well as DAMP-uncontrolled dysregulated pathological responses (acute and chronic human diseases) in the environmental health paradigm, called the "exposome" concept and the "adverse outcome pathway" (AOP) concept. • Evidence is discussed that DAMP-promoted controlled/uncontrolled innate immune/adaptive immune responses reflect the key events of the AOP concept. • The whole process starting from exposure to a distinct environmental stress/injury-associated with the presence/ emission of DAMPs-up to the manifestation of a disease may be regarded as an exposome. • Some exemplifying models of such a scenario are briefly sketched, including respiratory infections, autoimmune/ allergic diseases, organ fibrosis, and cancer. • In particular, a model in relation to the emerging COVID-19 pandemic is presented, where the interaction of noninfectious environmental factors (e.g., particulate matter) and infectious factors (SARS CoV-2) may promote SARS case fatality via superimposition of both exogenous and endogenous DAMPs.

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Section: The Exposome and Exposomicsmentioning

confidence: 99%

Role of Damage-Associated Molecular Patterns in Light of Modern Environmental Research: A Tautological Approach

Land

2020

Int J Environ Res

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“…This subtype of proteomics is focused on the small molecule chemical adducts of proteins, in particular cysteine residues [41]. This method has been proposed for applications in exposomics to measure the Environment portion shown in Figure 1 [42]. The combination of adductomics with metabolomics can provide a measure of the interaction between both the external exposome and the systemic alterations in oxidative stress.…”

Section: Study Design and Biosampling Designmentioning

confidence: 99%

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective

et al. 2019

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It is not controversial that study design considerations and challenges must be addressed when investigating the linkage between single omic measurements and human phenotypes. It follows that such considerations are just as critical, if not more so, in the context of multi-omic studies. In this review, we discuss (1) epidemiologic principles of study design, including selection of biospecimen source(s) and the implications of the timing of sample collection, in the context of a multi-omic investigation, and (2) the strengths and limitations of various techniques of data integration across multi-omic data types that may arise in population-based studies utilizing metabolomic data.

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“…The linkage with disease risks opens the way to EWAS. By taking a data‐driven, agnostic, unbiased approach, EWAS leads to more reproducible hypotheses . The goal of EWAS is to sort through the thousands of environmental stressors to which people are exposed during life and identify those few exposures that may be the causes of disease.…”

Section: The Exposomicsmentioning

confidence: 99%

Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document

Agache

Miller

Gern

et al. 2018

Allergy

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Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to allergic diseases and asthma. Under the PRAC- TALL collaboration between the European Academy of Allergy and ClinicalImmunology (EAACI) and the American Academy of Allergy, Asthma, and Immunology (AAAAI), we evaluated the current concepts and the unmet needs on the role of the exposome in allergic diseases and asthma.

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Redefining environmental exposure for disease etiology

Cited by 43 publications

References 67 publications

Role of Damage-Associated Molecular Patterns in Light of Modern Environmental Research: A Tautological Approach

Role of Damage-Associated Molecular Patterns in Light of Modern Environmental Research: A Tautological Approach

Integration of Metabolomic and Other Omics Data in Population-Based Study Designs: An Epidemiological Perspective

Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document

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