Redefining Reverse Remodeling

Waring, Ashley; Litwin, Sheldon E.

doi:10.1016/j.jacc.2016.07.718

Cited by 19 publications

(10 citation statements)

References 24 publications

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“…An increasing body of evidences in other pathological contexts, point to the fact that reverse remodeling starts at end-systole due to improvement of contractile function of the heart following the abolishment of either volume or pressure load. 28 To our knowledge this is the first paper to determine the status of MVP following transcatheter ASD closure and to correlate it to Biventricular reverse remodeling. In our patients, significant agreement has been depicted between results of biventricular remodeling as measured by 3D RV: LV ratio and MVP status.…”

Section: Discussionmentioning

confidence: 99%

Biventricular reverse remodeling and relationship with mitralvalve prolapse after transcatheter closure of ASD secundum, a 3Dechocardiographic study

El-Sisi

Dabour

Fattouh

et al. 2019

J Cardiovasc Thorac Res

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Introduction: Mitral valve prolapse (MVP) is the most common anomaly of the mitral valve. Several studies have shown prevalence of MVP in atrial septal defect (ASD) especially secundum types (II). The aims of this study is to show the potential role of 3D echocardiography in improving the diagnosis of MVP and to depict the relationship between reverse remodeling of the right and left ventricles (RV, LV) and MVP after transcatheter closure of ASD II. Methods: Sixty patients underwent transcatheter closure of ASD II and completed follow up by 2D and 3D echocardiography in Cairo University Children Hospital before the procedure and at 24 hours, 1 and 6 months after the procedure. Results: 3D echocardiography was more accurate than 2D echocardiography in detecting MVP frequency in ASD II patients (75% vs. 50%). Maximum statistically significant remodeling was detected by 3D echocardiography 1 month after the procedure (RV: LV ratio by 3D echocardiography 1.9±0.03 24 hours after the procedure vs. 1.6±0.03 1 months after the procedure, P < 0.01) while 2D echocardiography was delayed in detecting biventricular reverse remodeling. 3D derived RV: LV ratio was accurate in detecting MVP status with a sensitivity of 88%.

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Section: Discussionmentioning

confidence: 99%

Biventricular reverse remodeling and relationship with mitralvalve prolapse after transcatheter closure of ASD secundum, a 3Dechocardiographic study

El-Sisi

Dabour

Fattouh

et al. 2019

J Cardiovasc Thorac Res

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“…Adverse LV remodelling can be defined as an increase in LVESV >15% at follow‐up compared with baseline values 16 . A cutoff of >15% decrease from the baseline in LVESV was considered as a criterion of reverse LV remodelling, as this value is a validated reverse remodelling index in patients with ischemic heart disease 17,18 …”

Section: Methodsmentioning

confidence: 99%

Association of aortic stiffness early post myocardial infarction with left ventricular remodelling

Pavlidis,

Tsilivarakis,

Katogiannis

et al. 2023

Eur J Clin Investigation

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BackgroundAdverse left ventricular (LV) remodelling after myocardial infarction is associated with heart failure. We investigated whether aortic stiffness during acute ST‐segment elevation myocardial infarction is associated with LV remodelling at long‐term follow‐up.MethodsIn 109 patients within 48 h of myocardial infarction post‐primary percutaneous coronary intervention and after 2 years, we measured: (a) carotid to femoral pulse wave velocity (PWV), (b) LV global longitudinal strain (GLS) and left atrial strain using speckle‐tracking echocardiography, (c) PWV/GLS ratio as a surrogate marker of ventricular‐arterial interaction, and (d) LV end‐diastolic and end‐systolic volumes. A > 15% decrease from the baseline in LV end‐systolic volume at 2‐year follow‐up was considered as a criterion of reverse LV remodelling.ResultsCompared with baseline, all patients had reduced PWV, LV end‐diastolic and end‐systolic volumes while PWV/GLS, GLS and reservoir left atrial strain were improved (p < .05) after 2 years. Baseline values of PWV, GLS, PWV/GLS ratio and reservoir left atrial strain were associated with percentage change of LV end‐systolic volume at 2 years (p < .05). Multivariable analysis revealed that lower baseline values of PWV and a less impaired GLS and PWV/GLS were independently associated with reverse LV remodelling at 2 years with a C‐statistic of .748, .711 and .787, respectively.ConclusionAortic stiffness early post‐infarction determines LV remodelling after 2 years of the ischemic event despite post successful revascularization.Clinical Trial Registration‐URL: http://www.clinicaltrials.gov. Unique identifier: NCT03984123, 30/04/2020.

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“…Activation of inflammatory and coagulant pathways, cardiac fibrosis and microvascular obstruction promote adverse LV remodeling [2,3]. Conversely, reduction in LV volumes, defined as "reverse" LV remodeling, occurs in a proportion of post-infarct cases and is associated with improved cardiac function which, alongside pharmacotherapy targeting neurohormonal pathways, results in improved outcome and reduced progression to HF [4,5]. Change in LV end systolic volume (LVESV; applying a cutoff of ±15%) at six months after MI is a widely accepted echocardiographic measure to define adverse (−) or reverse (+) LV remodeling [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Conversely, reduction in LV volumes, defined as "reverse" LV remodeling, occurs in a proportion of post-infarct cases and is associated with improved cardiac function which, alongside pharmacotherapy targeting neurohormonal pathways, results in improved outcome and reduced progression to HF [4,5]. Change in LV end systolic volume (LVESV; applying a cutoff of ±15%) at six months after MI is a widely accepted echocardiographic measure to define adverse (−) or reverse (+) LV remodeling [5,6]. Given the relatively high interobserver variability in echocardiographic measurement of cardiac volumes, combining changes in LVESV with circulating biological markers associated with the pathophysiological process of LV remodeling may improve the accuracy of risk stratification to better guide clinical management and ensure patients at high-risk of adverse LV remodeling receive more timely and effective intervention.…”

Section: Introductionmentioning

confidence: 99%

Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction

Lim

Huang

Yatim

et al. 2022

IJMS

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The subset of plasma extracellular vesicles (EVs) that coprecipitate with low-density lipoprotein (LDL-EVs) carry coagulation and fibrinolysis pathway proteins as cargo. We investigated the association between LDL-EV hemostatic/fibrinolysis protein ratios and post-acute myocardial infarction (post-AMI) left ventricular (LV) remodeling which precedes heart failure. Protein concentrations of von Willebrand factor (VWF), SerpinC1 and plasminogen were determined in LDL-EVs extracted from plasma samples obtained at baseline (within 72 h post-AMI), 1 month and 6 months post-AMI from 198 patients. Patients were categorized as exhibiting adverse (n = 98) or reverse (n = 100) LV remodeling based on changes in LV end-systolic volume (increased or decreased ≥15) over a 6-month period. Multiple level longitudinal data analysis with structural equation (ML-SEM) model was used to assess predictive value for LV remodeling independent of baseline differences. At baseline, protein levels of VWF, SerpinC1 and plasminogen in LDL-EVs did not differ between patients with adverse versus reverse LV remodeling. At 1 month post-AMI, protein levels of VWF and SerpinC1 decreased whilst plasminogen increased in patients with adverse LV remodeling. In contrast, VWF and plasminogen decreased whilst SerpinC1 remained unchanged in patients with reverse LV remodeling. Overall, compared with patients with adverse LV remodeling, higher levels of SerpinC1 and VWF but lower levels of plasminogen resulted in higher ratios of VWF:Plasminogen and SerpinC1:Plasminogen at both 1 month and 6 months post-AMI in patients with reverse LV remodeling. More importantly, ratios VWF:Plasminogen (AUC = 0.674) and SerpinC1:Plasminogen (AUC = 0.712) displayed markedly better prognostic power than NT-proBNP (AUC = 0.384), troponin-I (AUC = 0.467) or troponin-T (AUC = 0.389) (p < 0.001) to predict reverse LV remodeling post-AMI. Temporal changes in the ratios of coagulation to fibrinolysis pathway proteins in LDL-EVs outperform current standard plasma biomarkers in predicting post-AMI reverse LV remodeling. Our findings may provide clinical cues to uncover the cellular mechanisms underpinning post-AMI reverse LV remodeling.

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Redefining Reverse Remodeling

Cited by 19 publications

References 24 publications

Biventricular reverse remodeling and relationship with mitralvalve prolapse after transcatheter closure of ASD secundum, a 3Dechocardiographic study

Biventricular reverse remodeling and relationship with mitralvalve prolapse after transcatheter closure of ASD secundum, a 3Dechocardiographic study

Association of aortic stiffness early post myocardial infarction with left ventricular remodelling

Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction

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