Redefining the normal angiogram using population-derived ranges for coronary size and shape: validation using intravascular ultrasound and applications in diverse patient cohorts

Mancini, G.B. John; Ryomoto, Arnold; C, Kamimura; Yeoh, Eunice; Ramanathan, Krishnan; Schulzer, Michael; Hamburger, J; Ricci, Donald R.

doi:10.1007/s10554-006-9199-z

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…Studies using IVUS (19,35,36) or CTA (13) have documented that coronary artery remodeling makes it very challenging to determine whether or not atherosclerosis is present from the “lumenogram” presented by selective coronary angiography. Some have proposed developing a method for quantifying angiographic estimates of coronary artery segmental size and shape (e.g., tapering) compared with sex- and segment-specific, population-derived, normal values (37). Registry data report that positive or expansive remodeling is associated with an elevated risk of acute coronary syndrome (ACS) (38-41).…”

Section: Is Coronary Atherosclerosis Present?mentioning

confidence: 99%

Emergence of Nonobstructive Coronary Artery Disease

Pepine

Ferdinand

Shaw

et al. 2015

Journal of the American College of Cardiology

262

117

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Recognition of ischemic heart disease (IHD) is often delayed or deferred in women. Thus, many at risk for adverse outcomes are not provided specific diagnostic, preventive, and/or treatment strategies. This lack of recognition is related to sex-specific IHD pathophysiology that differs from traditional models using data from men with flow-limiting coronary artery disease (CAD) obstructions. Symptomatic women are less likely to have obstructive CAD than men with similar symptoms, and tend to have coronary microvascular dysfunction, plaque erosion, and thrombus formation. Emerging data document that more extensive, nonobstructive CAD involvement, hypertension, and diabetes are associated with major adverse events similar to those with obstructive CAD. A central emerging paradigm is the concept of nonobstructive CAD as a cause of IHD and related adverse outcomes among women. This position paper summarizes currently available knowledge and gaps in that knowledge, and recommends management options that could be useful until additional evidence emerges.

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Section: Is Coronary Atherosclerosis Present?mentioning

confidence: 99%

Emergence of Nonobstructive Coronary Artery Disease

Pepine

Ferdinand

Shaw

et al. 2015

Journal of the American College of Cardiology

262

117

View full text Add to dashboard Cite

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“…2.2 within a predefined range. The reference (inlet) diameters vary between 2 and 6 mm, corresponding to g,0 = 1.0 ± 0.50 , fully covering the variation found in the statistical analysis of coronary arteries by Mancini et al (2007). Tapering values reported by the same authors led to the selection of g,4 = 1.0 ± 0.15 to represent healthy and diseased physiological tapering conditions.…”

Section: Geometry Databasementioning

confidence: 52%

Reduced-order modeling of blood flow for noninvasive functional evaluation of coronary artery disease

Buoso

Manzoni

Alkadhi

et al. 2019

Biomech Model Mechanobiol

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We present a novel computational approach, based on a parametrized reduced-order model, for accelerating the calculation of pressure drop along blood vessels. Vessel lumina are defined by a geometric parametrization using the discrete empirical interpolation method on control points located on the surface of the vessel. Hemodynamics are then computed using a reduced-order representation of the parametrized three-dimensional unsteady Navier-Stokes and continuity equations. The reduced-order model is based on an offline-online splitting of the solution process, and on the projection of a finite volume full-order model on a low-dimensionality subspace generated by proper orthogonal decomposition of pressure and velocity fields. The algebraic operators of the hemodynamic equations are assembled efficiently during the online phase using the discrete empirical interpolation method. Our results show that with this approach calculations can be sped up by a factor of about 25 compared to the conventional full-order model, while maintaining prediction errors within the uncertainty limits of invasive clinical measurement of pressure drop. This is of importance for a clinically viable implementation of noninvasive, medical imaging-based computation of fractional flow reserve.

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“…The AMCA variables are presented in Table 2 . When compared to reference control values for population-referenced AMCA [ 7 ], the group mean values of atheroma burden index were within reference control range, however maximal atheroma burden index values were higher than population-referenced control values. Group mean percent diameter stenosis was within the reference control range, and maximal percent diameter stenosis values were higher (more adverse) than population-referenced control values.…”

Section: Resultsmentioning

confidence: 99%

“…For each coronary arterial segment, anatomically defined using the Coronary Artery Surgery Study [ 6 ], AMCA were derived using the segment proximal diameter, reference diameter, minimal diameter, distal diameter and compared to population-referenced normal reference diameter for the coronary artery segment being analyzed ( Fig. 1 ) [ 7 ]. Angiographic atheroma burden index represents the level of focal stenosis in relation to a population-referenced normal reference diameter (abnormal > ±2 standard deviations [SD]).…”

Section: Methodsmentioning

confidence: 99%

“…Angiographic measurements of coronary anatomy (AMCA) for atheroma burden and tapering are developed and validated using IVUS [ 6 , 7 ]. Derived from pooled population-based studies examining coronary artery dimensions [ 6 , 8 , 9 ], AMCA are sensitive in detecting anomalies in coronary angiograms that are seemingly normal on visual assessment [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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