2006
DOI: 10.1016/s0022-5347(05)00442-8
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Redefining the Relationship Between Sperm Deoxyribonucleic Acid Fragmentation as Measured by the Sperm Chromatin Structure Assay and Outcomes of Assisted Reproductive Techniques

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Cited by 19 publications
(39 citation statements)
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“…Twenty studies [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] were indentified for our meta-analysis. The flow chart of the process for the identification of the studies were shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Twenty studies [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] were indentified for our meta-analysis. The flow chart of the process for the identification of the studies were shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Four studies [11,13,14,18], compared the DFI value between the pregnancy group with not pregnancy group and were included in the meta-analysis. Subgroup analysis was conducted by IVF and ICSI.…”
Section: Pregnant Group Versus Non-pregnant Groupmentioning
confidence: 99%
“…The characteristics of these 11 IVF studies included in the analysis are shown in Tables 2 and 3. Eleven otherwise valid studies must be excluded from meta-analysis because they either include a mixed protocol (IVF and IVF/ICSI; see below) [Larson-Cook et al 2003;Payne et al 2005;Seli et al 2004;Velez de la Calle et al 2008;Virro et al 2004] or a 2 × 2 analysis table could not be constructed because a cutoff level for DNA damage was not reported [Bakos et al 2008;Gu et al 2009;Meseguer et al 2008;Morris et al 2002;Tomlinson et al 2001;Tomsu et al 2002]. The results of this updated meta-analysis on IVF studies suggest that sperm DNA and chromatin damage has a modest influence on pregnancy rates at IVF and are in keeping with the results of a more limited meta-analysis [Collins et al 2008].…”
Section: Relationship Between Sperm Dna Damage and Pregnancymentioning
confidence: 99%
“…The characteristics of the 14 ICSI studies that could be evaluated are shown in Tables 4 and 5. Nine otherwise valid studies were removed from the meta-analysis because: (i) they included a mixed population (IVF and IVF/ICSI) [Larson-Cook et al 2003;Payne et al 2005;Seli et al 2004;Velez de la Calle et al 2008;Virro et al 2004], (ii) a 2 × 2 table could not be constructed [Bakos et al 2008;Morris et al 2002;Muriel et al 2006], or (iii) the assay type utilized in the study is not widely recognized [Virant-Klun et al 2002]. Although it may be surprising that studies indicate that sperm DNA and chromatin damage is not related to ICSI pregnancy, it is suspected that the careful selection of the sperm and embryo during human ICSI abrogates the likely adverse effect(s) of sperm DNA damage on reproductive outcomes [Gandini et al 2004].…”
Section: In Vitro Fertilization With Intracytoplasmic Sperm Injectionmentioning
confidence: 99%
“…The SCSA is the only DNA integrity test with substantial scientific literature supporting the credibility of this test for use in diagnosing male infertility, and up until 2007, patients whose sperm had a DNA fragmentation index (DFI)≥30 were told that their sperm had minimal to no chance for successful ART attempts at pregnancy [22,31,32]. However, as the number of clinics using ICSI in treating their infertile couples, this DFI cut-off began to be questioned as many groups using sperm with DFIs of 30 or higher were having excellent live birth outcome rates [23,43,60]. The reason for what many interpreted to be a loss of the SCSA's utility to predict ART outcome was not understood until the SCSA was evaluated for utility in predicting live birth outcome in each of the commonly used ART treatments, analyzing IUI, IVF, and ICSI live birth outcome as separate data sets.…”
Section: Discussionmentioning
confidence: 99%