Rediscovering the intricacies of secretory granule biogenesis

Campelo, Felix; Tian, Meng; von Blume, Julia

doi:10.1016/j.ceb.2023.102231

Cited by 3 publications

(2 citation statements)

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“…They release their contents slowly upon repeated stimulation or at low concentrations of calcium [12,13] , and are then replenished. Many reviews [4,[14][15][16][17][18] have been written about the mechanisms of sorting and packaging of peptide hormones and neurotrophins into the vesicles of the RSP. A brief summary of the RSP is presented in Figure 1.…”

Section: Mechanisms Of Protein Sorting At the Trans-golgi Network To ...mentioning

confidence: 99%

“…The sorting motif consists of a pair of acidic amino acids that bind to a pair of basic amino acids of the sorting receptor, membrane carboxypeptidase E (CPE), which is specifically associated with cholesterol-sphingolipid-rich lipid raft domains at the TGN membrane [Figure 2D]. The complex of either prohormone (POMC)-CPE or proBDNF-CPE then buds from the TGN to form DCV [17,[28][29][30][31][32][33][34] [Figure 2E]. In addition, the cytoplasmic tails of transmembrane proteins in DCVs also play a role in the sorting of RSP proteins to DCVs.…”

Section: Mechanisms Of Protein Sorting At the Trans-golgi Network To ...mentioning

confidence: 99%

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Cotton pillow samplers for assessment of thirdhand smoke in homes of smokers and nonsmokers with children

Quintana,

Lopez-Galvez,

Matt

et al. 2023

J Environ Expo Assess

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Secondhand smoke (SHS) exposure is a major cause of illnesses in children and leaves a persistent and toxic residue indoors called thirdhand smoke (THS) that adheres to various surfaces, permeates materials, accumulates in household dust, and is subsequently re-emitted into the air. THS, like SHS, has been shown to contain multiple toxic chemicals, including carcinogenic tobacco-specific nitrosamines (TSNAs). Children are highly susceptible to tobacco smoke pollutants, and simple methods for assessing children’s SHS and THS exposure are needed. Therefore, we evaluated the performance of a cotton pillow used as a passive sampler in homes of children with caregivers who smoke tobacco, with and without home smoking bans, as well as nonsmokers. We deployed a commercially available organic cotton travel pillow, which was left in the home for a median of 9.1 days. Pillow component nicotine levels were significantly higher in homes of smokers without a ban as compared to smokers and nonsmokers who had a ban (e.g., median pillowcase nicotine 337.7 ng/g per day vs. 72.5 ng/g per day and 0.1 ng/g per day, respectively) and differences were similar to those for air nicotine. Pillowcase TSNAs were detected mainly in the homes of smokers without a smoking ban. Pillow component (pillowcase, fabric, and filling) nicotine levels were highly correlated with air nicotine levels (rho = 0.76-0.88, all P < 0.001). Nicotine in the pillow components was also highly correlated with urinary cotinine in the children (rho = 0.65 to 0.81, all P < 0.001) and other measures of tobacco smoke exposure. Pillow performance as a sampler is promising, given the ease and simplicity of sample deployment.

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