Redox and pH dual-responsive biodegradable mesoporous silica nanoparticle as a potential drug carrier for synergistic cancer therapy

He, Yongju; Shao, Linjie; Hu, Yao; Zhao, Fuwen; Tan, Songwen; He, Dan; Pan, Anqiang

doi:10.1016/j.ceramint.2020.10.022

Cited by 28 publications

(11 citation statements)

References 32 publications

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“…This aldehyde group was grafted on MSNs surface to create a pH-responsive protein drug delivery system [ 71 ]. The disulfide group was successfully functionalized on MSNs via co-condensation method with bis(triethoxysilylpropyl)disulfide (BTES) as the functional group precursor [ 72 ]. Interestingly, one research group reported on the functionalization of MSNs with two compounds via the grafting process.…”

Section: Fabrication Of Msnsmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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Section: Fabrication Of Msnsmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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“…MSNs have become an interesting material in medicine [1,6,53,54,55,56]. In recent years, applications in the field of adsorption, catalysis, chemical separation, imaging, targeted anti-cancer agent, drug release, cell monitoring [40] biosensor, and solar cell [57] have been increasing rapidly (Fig.…”

Section: Mesoporous Silica Nanoparticles (Msns)mentioning

confidence: 99%

“…Therefore metal modified MSN can break down more easily. Further studies are needed to improve MSN's degradability [53]. Hao et al reported that changing PEG to MSN affected the rate of degradation.…”

Section: Bone Structure and Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Kütük

2021

International Journal of Life Sciences and Biotechnology

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Biomaterials are a large group of vitally important materials with many different inorganic and organic types. Biocomposites are produced by using materials such as polymer, metal, and ceramics. Bone tissue engineering deals with materials that can mimic the real bone structure found in the body. These materials used in the human body must be capable of many aspects such as their mechanical strength related to the area where they are used, as well as their properties such as biocompatible, biodegradable, and non-toxic. If the material is intended to treat the bone structure, it should be biodegradable, but it should be resistant to degradation if intended to be used for a long time. With the advance in technology, nanoparticles have become appealing in bone tissue engineering due to their many unique properties. In recent years, mesoporous silica nanoparticles (MSNs) have been prominent biomaterials in the medical field due to their properties such as alterable size structure, large pore volume, and surface area. This study aims to give information about the biomedical properties, synthesis methods, and importance of MSNs with unique properties in bone tissue engineering applications. This study is compiled by examining many studies in the literature.

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“…Therefore, traditional chemotherapy shows relatively low targeting effects and high toxicity. It is imperative to exploit new nano-scale drug delivery systems (NDDS) to solve the traditional chemotherapy side effects and improve targeting rates [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Redox-responsive mesoporous silica nanoparticles for chemo- photodynamic combination cancer therapy

Zhu

Zhang

Song

et al. 2022

Mater. Res. Express

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Traditional chemotherapy remains the primary cancer treatment, but it shows low enrichment and non-specificity. Hence, we have designed a multifunctional nanocarrier based on glutathione (GSH)-responsive mesoporous silica nanoparticles (MSNs). Firstly, disulfide bonds were linked on the surface of mesoporous silica. Then, doxorubicin (DOX) and chlorin e6 (Ce6) were co-loaded into the pores. Finally, carboxymethyl chitosan (CMCS) coated the nanoparticles to obtain the DOX/Ce6@MSN-SS-CMCS (DOX/Ce6@MSC) nanocarrier. The synthesized DOX/Ce6@MSC showed good monodispersity, dimensional stability, and consistent spectral characteristics. DOX/Ce6@MSC could effectively enter cancer cells and successfully deliver drugs. Under 660 nm laser irradiation, DOX/Ce6@MSC exhibited an effective photodynamic therapy effect that resists MCF-7 cells by triggering reactive oxygen species production. Thereby, it could efficiently inhibit cell proliferation and induce cell death. Anticancer analysis of tumor-bearing mice demonstrates that the DOX/Ce6@MSC combination treatment induced cell apoptosis effectively and showed an excellent antitumor effect in vivo. Therefore, DOX/Ce6@MSC nano-drug delivery system could be an effective strategy in cancer treatment.

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Redox and pH dual-responsive biodegradable mesoporous silica nanoparticle as a potential drug carrier for synergistic cancer therapy

Cited by 28 publications

References 32 publications

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

Mesoporous silica nanoparticles, methods of preparation and use of bone tissue engineering

Redox-responsive mesoporous silica nanoparticles for chemo- photodynamic combination cancer therapy

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