Redox conversions of new antiviral drug Triazavirin®: electrochemical study and ESR spectroscopy

4-Hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-c][1,2,4]triazines: synthesis, antiviral activity, and electrochemical characteristics

“…1). In voltammograms of 4-hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-с][1,2,4]triazines, there is a pronounced peak of the reduction of the nitro compound to the corresponding dimer at -0.5 V, as well as prominent anodic peaks at 0.2 and 1.1 V. Presumably, the anodic peak at E = 0.2 V in the voltammogram corresponds to the oxidation of the nitro compound to the corresponding hydroxylamine derivative, which agrees with literature data, 18 and the latter derivative is oxidized further to the nitroso compound at a potential of 1.1 V. It is found that the alkyl sulfanyl substituents in the structure of the studied molecules does not aff ect signifi cantly on the magnitude and position of the peaks in the voltammograms.…”

“…In the course of previous studies with the use of an integrated approach and combined methods for analysis, we proposed probable mechanisms of the electrochemical transformations of nitroazoloazines and showed their connection with the biological activity of a number of new antiviral compounds. 17, 18 The aims of the present study are the development of an effi cient method for the synthesis of 4-hydroxy-3-nitro-1,4-dihydrotriazolo[5,1-с][1,2,4]triazines with an alkyl sulfanyl group in the triazole ring, the analysis of electrochemical transformations and antiviral activity of prepared compounds.…”

The electrochemical behavior’s character of a potential antiviral drug 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate

“…The electrochemical behavior of compound 1 was studied using cyclic voltammetry, chronoamperometry, and a rotating disk electrode (RDE). The CV curves of this compound with a change in the sweep direction at the value of the potential of the limiting current of the first stage is similar to the peaks on the ECR curve of nitrobenzene in an acidic medium [18].…”

“…Previously, we studied the redox transformations of substances of a number of triazolotriazines (Triazavirin® and Triazide) [18,19]. The studies demonstrated that the electrochemical behavior of a structural analog may differ due to the difference in the structure and requires an individual approach to the investigation of its redox mechanism.…”

Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell

“…It is known that the diffusion coefficient for the nitroaromatic compounds in aqueous media is ~10 -5 cm 2 [19], the diameter of GCE is 2 mm, the concentration of CAP is 2•10 -3 M (in BRB pH = 5), the scan rate is 2 V/s. Based on the obtained results, we can assume that the electrochemical behavior of chloramphenicol in microcell accompanied with a pronounced cathodic peak corresponds to the 3-electron and 3-proton electroreduction of the nitro group with the formation of the corresponding dimer (Scheme 1).…”