Redox-dependent regulation of end-binding protein 1 activity by glutathionylation

Functions and Diseases of the Retinal Pigment Epithelium

“…Melanosomes also participate in the antioxidant process, scavenging oxygen free radicals. Several mechanisms have been shown to underpin the antioxidant capacity and regulation of RPE cells including the ERK signaling pathway ( Chong and Zheng, 2016 ; Chen et al, 2021 ); MMP-14 and TIMP-2 ( Alcazar et al, 2007 ); micro(mi)RNA-23 ( Lin et al, 2011 ); and toll-like receptor 3 (TLR3) ( Patel and Hackam, 2013 ).…”

HIV-1 exposure promotes PKG1-mediated phosphorylation and degradation of stathmin to increase epithelial barrier permeability

“…Our findings have important implications for the prevention of sexual transmission of HIV-1 because they indicate that HIV-1-induced disruption of epithelial cell junctions can be effectively abrogated by pharmacological inhibition of PKG1 activity. Additional studies are needed to determine whether specifically targeting stathmin phosphorylation, microtubule dynamics (46,47), or junctional complex formation can alleviate the effect of HIV-1 on epithelial cell junctions. Moreover, elucidating the molecular mechanisms underlying the earliest stages of HIV-1 infection can guide the development of effective vaccines and microbicides that block HIV-1 transmission and prevent systemic infection and associated pathologies.…”

USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B‐cell lymphoma

“…[9][10][11][12] USP21 is not only localized at microtubule to regulate microtubule dynamics but also posit on centriole to regulate primary cilium formation. [13][14][15][16][17] Moreover, USP21 plays a vital role in stem cell differentiation by regulating the polyubiquitination of Nanog. 18,19 USP21 can modulate cell cycle progression by deubiquitinating Forkhead box M1 (FOXM1) in basal-like breast cancer.…”