Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for Prevention of type 2 Diabetes

Shirahata, Sanetaka; Li, Y.; Hamasaki, Takeki; Gadek, Zbigniew; Teruya, Kiichiro; Kabayama, Shigeru; Otsubo, Kazumichi; Morisawa, Shinkatsu; Ishii, Yasuko; Katakura, Yoshinori

doi:10.1007/978-1-4020-5476-1_15

Cited by 11 publications

(11 citation statements)

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“…Reducing activity present in natural springs has been described to be beneficial for dermatological and antibacterial treatment [ 2 ]. It has been demonstrated that ERW shows reactive oxygen species- (ROS-) scavenging activity that could be useful in the treatment of oxidative stress-related diseases [ 3 , 4 ]. The first studies to support the use of ERW were performed in Japan in the 1930s and in the 1960s and it was recognized that ERW was effective in chronic diarrhea, gastrointestinal fermentation, and gastric hyperacidity [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro

Frajese

Benvenuto

Mattera

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Electrochemical reduced water (ERW) has been proposed to have beneficial effects on human health due to its rich content of H2 and the presence of platinum nanoparticles with antioxidant effects. Many studies have demonstrated that ERW scavenging properties are able to reduce the damage caused by oxidative stress in different experimental models. Although few in vivo studies have been reported, it has been demonstrated that ERW may display anticancer effects by induction of tumor cells apoptosis and reduction of both angiogenesis and inflammation. In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion. ERW decreased ErbB2/neu expression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells. In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors. Our in vivo results showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control. In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in tumor multiplicity. Overall, these results suggest a potential beneficial role of ERW in inhibiting cancer cells growth.

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Section: Introductionmentioning

confidence: 99%

Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro

Frajese

Benvenuto

Mattera

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Hydrogen molecule has been demonstrated to have excellent antioxidant as well as anti-inflammatory properties. Active hydrogen acts as antioxidant and showed protection of oxidative-induced damage in vitro [ 10 ]. It has also been reported that it can selectively scavenge reactive oxygen species (ROS) [ 11 ] and showed positive influence in cytokine imbalance [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

Ignacio

Kwak

Yun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW on Dermatophagoides farinae-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF-α), Th1 (IFN-γ, IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF-α, IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group. The results suggest that HW affects allergic contact dermatitis through modulation of Th1 and Th2 responses in NC/Nga mice. This is the first note on the drinking effect of HW on AD, clinically implying a promising potential remedy for treatment of AD.

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“…ERW at a pH of 9.8 has been reported to reduce levels of ROS in the blood plasma of patients with kidney disorders [12]. Previous studies have also confirmed active hydrogen atoms as demonstrating the ability to decrease the activities of ROS [11,12].…”

Section: Introductionmentioning

confidence: 87%

“…Electrolyzed reduced water (ERW) is also known as alkaline electrolyzed water, alkali-ionic water, alkaline cathodic water and alkaline ionized water. ERW can be defined as water with an alkaline pH which contains hydrogen-rich molecules [11]. Active hydrogen atoms can be obtained from ERW at the cathode by means of an electrolysis process.…”

Section: Introductionmentioning

confidence: 99%

Effect of electrolyzed reduced water on malondialdehyde levels and neutrophil cells in aggressive periodontitis

Rahardjo¹,

Ridwan²,

Hikmah³

2018

Trop. J. Pharm Res

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Purpose: To evaluate the effects of electrolyzed reduced water (ERW) on malondialdehyde (MDA) levels and neutrophil cells in Wistar rats suffering from aggressive periodontitis. Methods: Wistar rats (Rattus norvegicus) were infected with A. actinomycetemcomitans before being divided into a control group and a treatment group. The control group was treated orally with distilled water (pH 7.0), while the treatment group was administered with ERW (pH 9.8, 20 ml/day) for three successive days. Gingival tissue taken post-treatment was examined to determine the number of neutrophils and MDA level. Hematoxylin eosin staining was performed to identify neutrophil cells while MDA levels were determined by colorimetric assay. Results: The number of neutrophils in the control group (30.04 ± 15.30) was higher than that of the treatment group (7.76 ± 2.52), while the MDA levels of the control and treatment groups were 4.58 ± 0.66 and 4.30 ± 0.81, respectively (p < 0.05). Conclusion: ERW demonstrates the ability to reduce neutrophil cells without altering MDA levels in Wistar rats suffering from aggressive periodontitis. This is an indication that ERW was an effective material to manage aggressive periodontitis.

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Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for Prevention of type 2 Diabetes

Cited by 11 publications

References 0 publications

Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro

Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

Effect of electrolyzed reduced water on malondialdehyde levels and neutrophil cells in aggressive periodontitis

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