Redox regulation in lifespan determination

Karagianni, Christina; Bazopoulou, Daphne

doi:10.1016/j.jbc.2024.105761

Cited by 7 publications

(3 citation statements)

References 161 publications

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“…Interestingly, ROS play an important role in aging and lifespan [139]. Recently, it was demonstrated that BK Ca channels are present in Drosophila melanogaster mitochondria, and channel mutants induce structural and functional defects in mitochondria, leading to an increase in ROS [140].…”

Section: Discussionmentioning

confidence: 99%

Redox Regulation of Mitochondrial Potassium Channels Activity

Lewandowska,

Kalenik,

Wrzosek

et al. 2024

Antioxidants

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Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a substantial array of redox enzymes such as respiratory chain, and (3) the responsiveness of mitochondria to the cellular redox state. Within the inner mitochondrial membrane, a group of potassium channels, including ATP-regulated, large conductance calcium-activated, and voltage-regulated channels, is present. These channels play a crucial role in conditions such as cytoprotection, ischemia/reperfusion injury, and inflammation. Notably, the activity of mitochondrial potassium channels is intricately governed by redox reactions. Furthermore, the regulatory influence extends to other proteins, such as kinases, which undergo redox modifications. This review aims to offer a comprehensive exploration of the modulation of mitochondrial potassium channels through diverse redox reactions with a specific focus on the involvement of ROS.

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Section: Discussionmentioning

confidence: 99%

Redox Regulation of Mitochondrial Potassium Channels Activity

Lewandowska,

Kalenik,

Wrzosek

et al. 2024

Antioxidants

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“…Consequently, the antioxidant activity of cells can inactivate excess reactive oxygen species induced by low-dose ionising radiation. Conversely, reactive oxygen species in a range of physiological concentrations regulate cellular functions through cellular signalling systems [34]. These processes are initiated by a reversible conformational rearrangement of membrane macromolecules.…”

Section: Discussionmentioning

confidence: 99%

The response of human PMN zeta potential to selected ligands of the cAMP signal pathway under low-dose β-radiation

Zhirnov,

Iakovenko

2024

Preprint

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The objective of this study was to examine the zeta potential (ZP) response of human neutrophils to selected ligands of the cAMP signalling pathway under low-dose β-radiation (LDBR). ZP was calculated from the electrophoretic mobility (EPM) of the cells. Cells were irradiated at a dose rate of 10 µGy/hour for one hour. Irradiation of cell suspensions was conducted by adding appropriate aliquots of 14C-leucine to the incubation medium. EPM measurements were carried out in a radiation field. It was demonstrated that the LDBR and agonists of the AC system are capable of increasing the negative surface charge of human neutrophils. Conversely, the antagonist propranolol has been shown to reduce it. Furthermore, it has been demonstrated that radiation affects the response of the membrane ZP to some ligands of the AC pathway and vice versa. Therefore, LDBR can significantly alter the sensitivity of cells to drugs acting on the targets of these ligands. These results do not permit the conclusion that the effect of LDBR on ZP is mediated through the targets with which the studied ligands interact, since any of its components may undergo structural rearrangement, thereby altering the structural organisation of neutrophil membranes in the LDBR field.

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“…Similarly, nuclear factor erythroid-2-related factor-2 (Nrf2) is yet another redox-sensitive transcription factor that triggers the upregulation of anti-oxidant genes [189]. Exacerbated production of ROS in aging vessels tampers with Nrf2 activation, thereby increasing the sensitivity of blood vessels to the deleterious effects of ROS [190,191].…”

Section: Mapk Signalling In the Aging Heartmentioning

confidence: 99%

The Senescent Heart—“Age Doth Wither Its Infinite Variety”

Vijayakumar,

Wang,

Kailasam

2024

IJMS

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Cardiovascular diseases are a leading cause of morbidity and mortality world-wide. While many factors like smoking, hypertension, diabetes, dyslipidaemia, a sedentary lifestyle, and genetic factors can predispose to cardiovascular diseases, the natural process of aging is by itself a major determinant of the risk. Cardiac aging is marked by a conglomerate of cellular and molecular changes, exacerbated by age-driven decline in cardiac regeneration capacity. Although the phenotypes of cardiac aging are well characterised, the underlying molecular mechanisms are far less explored. Recent advances unequivocally link cardiovascular aging to the dysregulation of critical signalling pathways in cardiac fibroblasts, which compromises the critical role of these cells in maintaining the structural and functional integrity of the myocardium. Clearly, the identification of cardiac fibroblast-specific factors and mechanisms that regulate cardiac fibroblast function in the senescent myocardium is of immense importance. In this regard, recent studies show that Discoidin domain receptor 2 (DDR2), a collagen-activated receptor tyrosine kinase predominantly located in cardiac fibroblasts, has an obligate role in cardiac fibroblast function and cardiovascular fibrosis. Incisive studies on the molecular basis of cardiovascular aging and dysregulated fibroblast function in the senescent heart would pave the way for effective strategies to mitigate cardiovascular diseases in a rapidly growing elderly population.

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Redox regulation in lifespan determination

Cited by 7 publications

References 161 publications

Redox Regulation of Mitochondrial Potassium Channels Activity

Redox Regulation of Mitochondrial Potassium Channels Activity

The response of human PMN zeta potential to selected ligands of the cAMP signal pathway under low-dose β-radiation

The Senescent Heart—“Age Doth Wither Its Infinite Variety”

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