Redox regulation of cellular processes: A biophysical model and experiment

Мартинович, Г. Г.; Мартинович, И. В.; Sn, Cherenkevich

doi:10.1134/s0006350911030171

Cited by 9 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the one hand, this adaptogen can reduce the expression level of inflammatory cytokines (TNF-α, IL-6, and COX-2) and fibrotic markers (PC1 and TGF-β) by inhibiting the NF-κB enzyme. On the other hand, it can initiate antioxidant protection in mononuclear cells (14) by increasing the expression of CAT and MnSOD, NADPH oxidase (p22 and NOX2)/and other antioxidant enzymes (15). MT activates mitochondrial oxidative phosphorylation (13), preventing the formation of free radicals and depletion of cellular energy reserves (14), thereby exhibiting powerful cardio-, vaso-and neuroprotective properties.…”

Section: Introductionmentioning

confidence: 99%

N-[2-(5-methoxy-1h-indole-3-yl)ethyl]acetamide may correct arterial hypertension in people with sleep problems

Осадчук¹,

Vasilieva²,

Mironova³

et al. 2023

Acta fac medic Naissensis

View full text Add to dashboard Cite

Introduction. Sleep disturbance is a frequent complaint of patients suffering from arterial hypertension (AH) for a long time. A hidden and uncontrolled increase in blood pressure (BP) makes the course of physiological processes more difficult, disrupts the regulation of biological rhythms, and increases the risk of cardiovascular complications even with a short duration of AH. At the same time, chronic sleep disorders contribute to the development of hypertension, defining the role of a new socially significant risk factor. An important role in the pathogenesis of insomnia is played by a deficiency in melatonin (MT) synthesis, which negatively affects the cardiovascular system (CVS). Aim. The aim of the paper was to study the features of central and vascular hemodynamics in patients with the 1st degree AH and to evaluate the clinical effectiveness of antihypertensive therapy with synthetic analog of prolonged-release MT at the onset of the disease. Methods. Instrumental examination included registration of an electrocardiogram, office measurement of blood pressure with an automatic tonometer, non-invasive automatic blood pressure monitoring for 24 hours. The severity of insomnia was assessed by somnological questionnaires. Representatives of the 1st group (n = 34) took monotherapy with the ACE inhibitor ramipril, participants of the 2nd group (n = 33) took the ACE inhibitor ramipril in combination with a synthetic analogue of melatonin. Results. The results of a randomized open prospective study including 78 participants reveal the activity of the renin-angiotensin-aldosterone system (RAAS), hypersympathicotonia at night and desynchronosis due to a possible deficiency in the MT secretion. Pharmacological antihypertensive therapy with the addition of prolonged release MT analog was accompanied by a significant improvement in the clinical condition of hypertensive patients. Positive dynamics of indicators of systemic hemodynamics and functional arterial parameters of stiffness was noted. Conclusion. The article describes the probable benefits of melatonin as part of combination antihypertensive therapy in patients with early-stage hypertension and insomnia. Additional introduction of MT at the onset of the AN as a physiological regulator of circadian biological rhythms is substantiated.

show abstract

Section: Introductionmentioning

confidence: 99%

N-[2-(5-methoxy-1h-indole-3-yl)ethyl]acetamide may correct arterial hypertension in people with sleep problems

Осадчук¹,

Vasilieva²,

Mironova³

et al. 2023

Acta fac medic Naissensis

View full text Add to dashboard Cite

show abstract

“…All biological systems contain redox elements that play an important role in transcriptional regulation, cell proliferation, apoptosis, hormonal signaling, and other fundamental cell functions [3]. Organization and coordination of the redox activity of these elements occur through redox circuits and depend on the intracellular concentration of redox-active molecules [4, 5]. Redox active molecules may cause both regulatory and toxic effects depending on the value of cellular redox state parameters [5, 6].…”

Section: Introductionmentioning

confidence: 99%

“…Organization and coordination of the redox activity of these elements occur through redox circuits and depend on the intracellular concentration of redox-active molecules [4, 5]. Redox active molecules may cause both regulatory and toxic effects depending on the value of cellular redox state parameters [5, 6]. However, little is known about mechanisms of regulation, structural organization, and interaction between electron-transport participants inside the cell and other signal and regulatory systems.…”

Section: Introductionmentioning

confidence: 99%

Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain

Мартинович

Голубева

Мартинович

et al. 2012

Journal of Biophysics

View full text Add to dashboard Cite

Previously, we have reported that ascorbic acid regulates calcium signaling in human larynx carcinoma HEp-2 cells. To evaluate the precise mechanism of Ca2+ release by ascorbic acid, the effects of specific inhibitors of the electron transport chain components on mitochondrial reactive oxygen species (ROS) production and Ca2+ mobilization in HEp-2 cells were investigated. It was revealed that the mitochondrial complex III inhibitor (antimycin A) amplifies ascorbate-induced Ca2+ release from intracellular stores. The mitochondrial complex I inhibitor (rotenone) decreases Ca2+ release from intracellular stores in HEp-2 cells caused by ascorbic acid and antimycin A. In the presence of rotenone, antimycin A stimulates ROS production by mitochondria. Ascorbate-induced Ca2+ release in HEp-2 cells is shown to be unaffected by catalase. The results obtained suggest that Ca2+ release in HEp-2 cells caused by ascorbic acid is associated with induced mitochondrial ROS production. The data obtained are in line with the concept of redox signaling that explains oxidant action by compartmentalization of ROS production and oxidant targets.

show abstract

“…Согласно предложенному механизму, кроме редокс-активных соединений и их мишеней в редокс-регуляторных процессах участвуют также белки-ферменты -оксидоредуктазы, локализация которых вблизи белков-мишеней определяет специфический отклик клеток. При этом регуляторный эффект действия редокс-активных соединений определяется не конкретной молекулой, а группой взаимодействующих участников, образующих электрон-транспортные цепи (редокс-цепи), и зависит от величин параметров редокс-гомеостаза [11]. Компонентами биологических электрон-транспортных цепей являются оксидоредуктазы и эндогенные редокс-активные соединения, включая АФК и антиоксиданты.…”

unclassified

Regulation of the Proliferative Activity and Chemoresistance in Tumor Cells by Sodium Ascorbate

et al. 2018

View full text Add to dashboard Cite

РЕГУЛЯЦИЯ ПРОЛИФЕРАТИВНОЙ АКТИВНОСТИ И ХИМИОРЕЗИСТЕНТНОСТИ ОПУХОЛЕВЫХ КЛЕТОК АСКОРБАТОМ НАТРИЯ Аннотация. Исследовано влияние аскорбата в физиологических концентрациях на пролиферативную активность и химиорезистентность клеток карциномы гортани человека линии НЕр-2. Установлено, что при действии аскорбата в концентрации 60 мкМ скорость пролиферации опухолевых клеток увеличивается в 1,5 раза. Аскорбат вызывает изменение функционального состояния опухолевых клеток, в результате которого увеличивается их резистентность к доксорубицину и тимохинону. Показано, что ингибитор НАДФН-оксидазы апоцинин блокирует стимулирующий эффект антиоксиданта. Полученные результаты свидетельствуют об участии активных форм кислорода, продуцируемых НАДФН-оксидазой, в механизме активации адаптационного ответа клеток, индуцированного аскорбатом.

show abstract

Redox regulation of cellular processes: A biophysical model and experiment

Cited by 9 publications

References 26 publications

N-[2-(5-methoxy-1h-indole-3-yl)ethyl]acetamide may correct arterial hypertension in people with sleep problems

N-[2-(5-methoxy-1h-indole-3-yl)ethyl]acetamide may correct arterial hypertension in people with sleep problems

Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain

Regulation of the Proliferative Activity and Chemoresistance in Tumor Cells by Sodium Ascorbate

Contact Info

Product

Resources

About