Redox Regulation of the Microcirculation

Kadlec, Andrew O.; Gutterman, David D.

doi:10.1002/cphy.c180039

Cited by 8 publications

(5 citation statements)

References 432 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The erythrocyte is considered to control the local blood flow via three possible nitric oxide‐mediated mechanisms: (i) release ATP to stimulate the production of nitric oxide by the endothelial cells, (ii) release nitric oxide derived from nitrosohaemoglobin, and (iii) release nitric oxide derived from the nitric oxide synthases and the nitrate–nitrite–nitric oxide reduction pathway in the erythrocyte 104,176,454,508–518 . Products of normal nitrogen metabolism, such as nitrosothiols 100 and peroxynitrite, can also induce vasodilation 519–522 . During low oxygen tension, the erythrocyte deformation increases ATP release via the activation of mechanosensitive Piezo1 channels 523 .…”

Section: The Dynamics Of Erythrocyte Metabolismmentioning

confidence: 99%

“…104,176,454,[508][509][510][511][512][513][514][515][516][517][518] Products of normal nitrogen metabolism, such as nitrosothiols 100 and peroxynitrite, can also induce vasodilation. [519][520][521][522] During low oxygen tension, the erythrocyte deformation increases ATP release via the activation of mechanosensitive Piezo1 channels. 523 On the other, limited ATP release has been shown to impair microvascular blood flow.…”

Section: The Erythrocyte Transports Carbon Dioxide and Buffers Ph In ...mentioning

confidence: 99%

See 1 more Smart Citation

Erythrocyte metabolism

Chatzinikolaou,

Margaritelis,

Paschalis

et al. 2024

Acta Physiologica

View full text Add to dashboard Cite

Our aim is to present an updated overview of the erythrocyte metabolism highlighting its richness and complexity. We have manually collected and connected the available biochemical pathways and integrated them into a functional metabolic map. The focus of this map is on the main biochemical pathways consisting of glycolysis, the pentose phosphate pathway, redox metabolism, oxygen metabolism, purine/nucleoside metabolism, and membrane transport. Other recently emerging pathways are also curated, like the methionine salvage pathway, the glyoxalase system, carnitine metabolism, and the lands cycle, as well as remnants of the carboxylic acid metabolism. An additional goal of this review is to present the dynamics of erythrocyte metabolism, providing key numbers used to perform basic quantitative analyses. By synthesizing experimental and computational data, we conclude that glycolysis, pentose phosphate pathway, and redox metabolism are the foundations of erythrocyte metabolism. Additionally, the erythrocyte can sense oxygen levels and oxidative stress adjusting its mechanics, metabolism, and function. In conclusion, fine‐tuning of erythrocyte metabolism controls one of the most important biological processes, that is, oxygen loading, transport, and delivery.

show abstract

Section: The Dynamics Of Erythrocyte Metabolismmentioning

confidence: 99%

Section: The Erythrocyte Transports Carbon Dioxide and Buffers Ph In ...mentioning

confidence: 99%

Erythrocyte metabolism

Chatzinikolaou,

Margaritelis,

Paschalis

et al. 2024

Acta Physiologica

View full text Add to dashboard Cite

show abstract

“…IN HYPERGLYCEMIA Sources of ROS in endothelial cells are NADPH oxidases, mitochondrial respiratory chain, NOS, xanthine oxidases, peroxidases, cyclooxygenases, and lipoxygenases [194][195][196]. NADPH oxidase which catalyzes the production of superoxide anion radical, a precursor of other ROS, is a main player.…”

Section: The Role Of Reactive Oxygen Species In Vascular Dysfunctionmentioning

confidence: 99%

Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

et al. 2022

View full text Add to dashboard Cite

The review presents modern ideas about peripheral microhemodynamics, approaches to the ana-lysis of skin blood flow oscillations and their diagnostic significance. Disorders of skin microhemodynamics in type 2 diabetes mellitus (DM) and the possibility of their interpretation from the standpoint of external and internal interactions between systems of skin blood flow regulation, based on a comparison of couplings in normal and pathological conditions, including models of pathologies on animals, are considered. The factors and mechanisms of vasomotor regulation, among them receptors and signaling events in endothelial and smooth muscle cells considered as models of microvessels are discussed. Attention was drawn to the disturbance of Ca 2+ -dependent regulation of coupling between vascular cells and NO-dependent regulation of vasodilation in diabetes mellitus. The main mechanisms of insulin resistance in type 2 DM are considered to be a defect in the number of insulin receptors and impaired signal transduction from the receptor to phosphatidylinositol-3-kinase and downstream targets. Reactive oxygen species plays an important role in vascular dysfunction in hyperglycemia. It is assumed that the considered molecular and cellular mechanisms of microhemodynamics regulation are involved in the formation of skin blood flow oscillations. Parameters of skin blood microcirculation can be used as diagnostic and prognostic markers for assessing the state of the body.

show abstract

“…Значимое снижение вклада Аэ частотного спектра регуляции МКЦ, наблюдаемое у больных с ХСН, по сравнению с группой контроля (4,9 vs 12,3%) (рисунок 2), можно рассматривать как проявление выраженной эндотелиальной дисфункции. Отсутствие корреляций между Аэ и параметрами внутрисердечной гемодинамики представляется весьма логичным в связи с большей зависимостью этого регуляторного компонента частотного спектра от локальных нейрогормональных механизмов [8,17,[21][22][23][24]. Хорошо известна роль оксида азота, простациклина, некоторых интерлейкинов, кальцитонин-ген-родственного пептида, субстанции Р во влиянии на тонус сосудов микроциркуляторного русла [2,16,25], однако оценка влияния многих других биологически активных молекул (гаптоглобина, копептина и др.)…”

Section: таблицаunclassified

“…Принято считать, что спазмирование артериол и прекапилляров, а также извилистость и полнокровие посткапилляров и собирательных венул, выявляемые при морфологических исследованиях у больных с ХСН [19,20], носят приспособительный характер и направлены на улучшение транскапиллярного обмена путем увеличения перфузионного давления [21][22][23]. Таким образом, выявленные в настоящем исследовании корреляционные взаимосвязи между Ам и ФВ ЛЖ, систолическими и диастолическими размерами и объемами ЛЖ (таблица 5) свидетельствуют о компенсаторном повышении мышечного тонуса прекапилляров при прогрессировании ХСН.…”

Section: заключениеunclassified

Skin microcirculation in patients with heart failure with different left ventricular systolic dysfunction

Подзолков

Dragomiretskaya

Beliaev

et al. 2021

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Aim. To study the relationship of mechanisms of microcirculation regulation and intracardiac hemodynamics in patients with heart failure (HF).Material and methods. In eighty patients with NYHA class II-IV HF, microcirculation was assessed by laser Doppler flowmetry and intracardiac hemodynamics — by echocardiography.Results. The patients were divided into 3 groups depending on HF type: with preserved ejection fraction (CHpEF) (>50%) — 27 patients, mid-range EF (CHmrEF) (40-50%) — 25 patients, reduced EF (CHrEF) (<40%) — 28 patients. Comparative analysis revealed a significant decrease in the coefficient of variation (CV) in all groups without microcirculation differences. The greatest number of significant correlations was found between the myogenic component of microcirculation frequency range and the following echocardiographic parameters: left ventricular EF (r=0,351, p<0,05); end-diastolic dimension (r=-0,492, p<0,05), end-systolic dimension (r=-0,474, p<0,05), end-diastolic volume (r=-0,544, p<0,05), end-systolic volume (r=-0,449, p<0,05), etc.Conclusion. In patients, regardless of left ventricular EF, satisfactory perfusion was obtained, which is achieved due to inhibition of active mechanisms and compensatory activation of passive mechanisms of microcirculation regulation. The relationship between the development of myocardial remodeling and microcirculatory dysfunction is noted.

show abstract

Redox Regulation of the Microcirculation

Cited by 8 publications

References 432 publications

Erythrocyte metabolism

Erythrocyte metabolism

Skin Microhemodynamics and Mechanisms of Its Regulation in Type 2 Diabetes Mellitus

Skin microcirculation in patients with heart failure with different left ventricular systolic dysfunction

Contact Info

Product

Resources

About