Redox-responsive hydrogels of thiolated pectin as vehicles for the smart release of acetaminophen

Quadrado, Rafael F.N.; Macagnan, Karine Laste; Moreira, Angelita da Silveira; Fajardo, André R.

doi:10.1016/j.reactfunctpolym.2022.105448

Cited by 6 publications

(2 citation statements)

References 57 publications

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“…Release mechanisms in pectin hydrogels are a complex interplay of various factors that influence the controlled delivery of bioactive compounds ( Groult et al, 2021 ). These mechanisms typically involve a combination of diffusion ( Siddiqua et al, 2022 ), erosion ( Quadrado et al, 2022 ), and relaxation of the hydrogel matrix. As the hydrogel absorbs water, it swells, creating channels through which the entrapped drugs or molecules diffuse.…”

Section: Drug Entrapment In Pectin Hydrogelsmentioning

confidence: 99%

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Kapoor,

Garg,

Gaur

et al. 2024

Saudi Pharmaceutical Journal

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Section: Drug Entrapment In Pectin Hydrogelsmentioning

confidence: 99%

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Kapoor,

Garg,

Gaur

et al. 2024

Saudi Pharmaceutical Journal

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“…[ 163 ] Thiolated poly‐ and oligosaccharides can thus form hydrogels with antioxidative properties and responsiveness to the cellular redox environment. [ 164 ] These properties are crucial in regulating various aspects of cell behavior, including cell metabolism and apoptosis. Sulfhydryl groups can scavenge free radicals and reactive oxygen species (ROS).…”

Section: Properties Of Thiolated Poly‐ and Oligosaccharidesmentioning

confidence: 99%

Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing

Noreen,

Bernkop‐Schnürch

2023

Adv Funct Materials

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Due to thiolation of poly‐ and oligosaccharides numerous favorable properties for tissue engineering and wound healing can be introduced. Poly‐ and oligosaccharides can be thiolated via hydroxyl‐to‐thiol conversions or the covalent attachment of sulfhydryl ligands to hydroxyl, carbonic acid or amino groups on them. Since thiolated poly‐ and oligosaccharides can cross‐link via disulfide bonds, they form stable 3D networks with defined microarchitecture, stiffness, elasticity, and degradability. Furthermore, thiol groups can enhance cell adhesion since cells exhibit cysteine‐rich subdomains on their surface that form disulfide bonds with them. Sulfhydryl groups can also participate in cell signaling pathways favoring various cellular processes like proliferation, migration, spreading, and differentiation that are beneficial for tissue engineering and wound healing. In addition, a controlled release of active ingredients such as growth factors being bound via disulfide bonds to thiolated poly‐ and oligosaccharides can be achieved via thiol/disulfide exchange reactions. Over the last two decades, the number of thiolated poly‐ and oligosaccharides such as thiolated hyaluronic acid and thiolated chitosan used for tissue engineering and wound healing has increased tremendously. Within this review, an overview is provided about the chemistry of thiolated poly‐ and oligosaccharides, their key properties, applications and performance in clinical trials and as marketed products.

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Recent advances in 3D bioprinted polysaccharide hydrogels for biomedical applications: A comprehensive review

Damiri,

Fatimi,

Liu

et al. 2025

Carbohydrate Polymers

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Redox-responsive hydrogels of thiolated pectin as vehicles for the smart release of acetaminophen

Cited by 6 publications

References 57 publications

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Pectin hydrogels for controlled drug release: Recent developments and future prospects

Thiolated Poly‐ and Oligosaccharide‐Based Hydrogels for Tissue Engineering and Wound Healing

Recent advances in 3D bioprinted polysaccharide hydrogels for biomedical applications: A comprehensive review

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