Redox-responsive mesoporous silica as carriers for controlled drug delivery: A comparative study based on silica and PEG gatekeepers

Wang, Ying; Han, Ning; Zhao, Qinfu; Bai, Ling; Li, Jia; Jiang, Tongying; Wang, Siling

doi:10.1016/j.ejps.2015.02.008

Cited by 96 publications

(33 citation statements)

References 33 publications

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“…* this route does not overcome the "PEG dilemma" and the very limited uptake of PEGylated nanoparticles is a major drawback of these systems. [46][47][48][49] Micelles [50] Hydrazone Liposomes [52][53][54] Micelles [55][56][57][58][59][60][61] Acetal Liposomes [62] Micelles [63][64][65][66][67][68][69] β-thiopropionate Micelles [70] Ortho ester Liposomes [71][72][73] Benzoic-imine Micelles [74][75][76] Reduction Glutathione (GSH) (2-10 mM) Liposomes [93] Polymersomes [94,95] Micelles 133] Graphene Oxide [122][123][124] Mesoporous silica nanoparticles (MSN) [125][126][127][128][129][130][131][132] Magnetic nanoparticles [134] Enzymatic Cathepsin B (peptide consensus sequence)…”

Section: Resultsmentioning

confidence: 99%

DePEGylation strategies to increase cancer nanomedicine efficacy

2019

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Section: Resultsmentioning

confidence: 99%

DePEGylation strategies to increase cancer nanomedicine efficacy

2019

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“…Materials composed of stimuli-responsive polymer and mesoporous silica have been synthesized widely [1]- [11]. Such composites are expected to be used as a carrier for drug delivery system (DDS), a column packing agent for stimuli-responsive chromatography, and so on.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of P(NIPAM-co-Am)/Mesoporous Silica Composites and Their Temperature- Responsive Anion Exchange

Murakami

Sato²,

Inoue³

2015

MSCE

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The purpose of this study is to examine the structure and the temperature-responsive anion exchange property of amino-functionalized mesoporous silica coated with temperature-responsive copolymer, poly(N-isopropylacrylamide-co-acrylamide) (P(NIPAM-co-Am)). For this purpose, the composites which contained 0, 10, or 20 wt% of Am were synthesized. From the TG results, it was found that the amounts of copolymer immobilized on the mesoporous silica were 1.6-2.6 wt%. XRD patterns revealed that the structures of composites were hexagonal and almost the same as that of original mesoporous silica without polymer. At low temperature the methyl orange (MO) anions adsorbed and desorbed reversibly with changing pH of the solution, while at high temperature the MO anions did not. This temperature, at which the amount of adsorbed MO anions changed considerably, shifted to the higher temperature side with increasing the amount of added Am.

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“…Furthermore, Amino-CMSN showed significant lower haemolysis ratio than CMSN. Factors that may influence the haemolytic behaviour mainly include the electrostatic interactions between silanol groups and the positively charged groups of membrane proteins, the strong affinity between silica and tetraalkylammonium groups present in the membrane of red blood cells [48]. In our study, the surface modification of CMSN with amino groups can shield the negatively charged silanol groups, thus depressing haemolysis.…”

Section: Haemolysis Assaymentioning

confidence: 72%

“…It has been reported that mesoporous silica nanoparticles can nonspecific adsorb to serum protein in vivo [48]. As presented in Figure 6, CMSN had a considerable BSA adsorption amount of 9.65% mainly because surface silanol groups of MSNs were rich and showed nonspecific binding to BSA via hydrogen bonding interactions.…”

Section: Bsa Adsorptionmentioning

confidence: 94%

Superiority of amino-modified chiral mesoporous silica nanoparticles in delivering indometacin

Guo

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The present study established indometacin (IMC) delivery system with chiral mesoporous silica nanoparticles (CMSNs) and amino-modified chiral mesoporous silica nanoparticles (Amino-CMSNs) that previously reported as pharmaceutical excipients, and their systemic biological effects, mainly consisting of in vitro drug intestinal permeability, haemolysis assay, in vivo pharmacokinetics, anti-inflammation pharmacodynamics and gastric irritation, were addressed. It turned out that the two IMC delivery systems established by CMSN and Amino-CMSN significantly improved drug intestinal permeability due to the improved drug dissolution caused by conversion of drug crystalline state to amorphous phase. Further, IMC-loaded Amino-CMSN was the superior choice because of its higher dissolution rate. Furthermore, CMSN and Amino-CMSN were safe to be circulated in blood, and Amino-CMSN with significant lower haemolysis ratio than CMSN was better for the minimum haemolytic behaviour. Oral bioavailability and anti-inflammation effect of IMC delivery systems established by CMSN and Amino-CMSN were enhanced compared with IMC, which was attributed to the primary cause of the improvement of IMC dissolution, and Amino-CMSN exhibited better biological effect. As a result of these facts, it is believed that the effective delivery of IMC by Amino-CMSN will provide a new candidate to formulate poorly soluble drugs so as to significantly develop pharmaceutical application.

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Redox-responsive mesoporous silica as carriers for controlled drug delivery: A comparative study based on silica and PEG gatekeepers

Cited by 96 publications

References 33 publications

DePEGylation strategies to increase cancer nanomedicine efficacy

DePEGylation strategies to increase cancer nanomedicine efficacy

Synthesis of P(NIPAM-co-Am)/Mesoporous Silica Composites and Their Temperature- Responsive Anion Exchange

Superiority of amino-modified chiral mesoporous silica nanoparticles in delivering indometacin

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