Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles

Lin, Jiantao; Liu, Zong-Kun; Zhu, Qing–Ling; Rong, Xiaohui; Liang, Cui-Ling; Wang, Jie; Ma, Dong; Sun, Jing; Wang, Guan-Hai

doi:10.1016/j.colsurfb.2017.04.002

Cited by 131 publications

(57 citation statements)

References 39 publications

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“…Target molecules allow the MSNs to reach the tumor tissue only through a molecular recognition mechanism. Then, once in the internal tissue, the stimuliresponsive capping agent [5,34] permits the release of the drug as a response to internal (change of pH [42][43][44][45], temperature [46][47][48], redox reactions [40,[49][50][51][52]) or external (irradiation with light [53][54][55], magnetic field [55][56][57]) stimuli.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Nairi¹,

Magnolia²,

Piludu³

et al. 2018

Colloids and Surfaces B: Biointerfaces

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Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. To this purpose, three hyaluronic acid samples differing for the molecular weight, namely HA (8-15 kDa), HA (30-50 kDa) and HA (90-130 kDa), were used. The MSN-HA, MSN-HA, and MSN-HA materials were characterized through zeta potential and dynamic light scattering measurements at pH = 7.4 and T = 37 °C to simulate physiological conditions. While zeta potential showed an increasing negative value with the increase of the HA chain length, an anomalous value of the hydrodynamic diameter was observed for MSN-HA, which was smaller than that of MSN-HA and MSN-HA samples. The cellular uptake of MSN-HA samples on HeLa cells at 37 °C was studied by optical and electron microscopy. HA chain length affected significantly the cellular uptake that occurred at a higher extent for MSN-NH and MSN-HA than for MSN-HA and MSN-HA samples. Cellular uptake experiments carried out at 4 °C showed that the internalization process was inhibited for MSN-HA samples but not for MSN-NH. This suggests the occurrence of two different mechanisms of internalization. For MSN-NH the uptake is mainly driven by the attractive electrostatic interaction with membrane phospholipids, while MSN-HA internalization involves CD44 receptors overexpressed in HeLa cells.

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Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Nairi¹,

Magnolia²,

Piludu³

et al. 2018

Colloids and Surfaces B: Biointerfaces

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“…The concentration of extracellular GSH is 1-20 μmolL −1 , that is insufficient to reduce disulfide bonds. However, the concentration of tumor/intracellular GSH is about 0.5−10 mmolL −1 , the disulfide bonds could be reduced by this concentration of GSH, resulting in the effective drugs release from the carriers (29,30).…”

Section: Redox-triggered Releasementioning

confidence: 99%

Mesoporous silica nanoparticles for drug delivery—Recent advances

2019

Adv.App.Mater.

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Mesoporous silica nanoparticles (MSNs) have been attracting great attention for the potential biomedical applications in the last decades. Due to the unique properties, such as tunable mesoporous structure, huge surface area, large pore volume, as well as the functional ability of surface, MSNs exhibit high loading capacity for therapeutic active pharmaceutical ingredients (APIs) and controllable release behavior. In this review, the applications of MSNs in pharmaceutics improving the bioavailability, reducing toxicity of loaded drugs, increasing cellular targeted delivery ability and recent advances in drug delivery are summarized.

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“…Mesoporous silica NPs are also suitable for nanotherapeutics in cancer due to their unique porous structure, tunable pore size, and the ability to release drugs in response to pH, temperature, light, redox reactions, enzymes, or biomolecules (Cheng et al, 2017 ; Lin et al, 2017 ; Yan et al, 2017 ; Zhan et al, 2017 ). Zhou et al ( 2017 ) incorporated DOX into the pores of pH-sensitive MSNs, whose pH-responsive mechanism enabled the controlled release of low levels of drug at a physiological pH and efficient intracellular release under more acidic conditions, characteristic of endosomal and lysosomal environments.…”

Section: Nps Applications In Liquid Tumorsmentioning

confidence: 99%

Nanoparticles—Emerging Potential for Managing Leukemia and Lymphoma

Vinhas

Mendes

Fernandes

et al. 2017

Front. Bioeng. Biotechnol.

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Nanotechnology has become a powerful approach to improve the way we diagnose and treat cancer. In particular, nanoparticles (NPs) possess unique features for enhanced sensitivity and selectivity for earlier detection of circulating cancer biomarkers. In vivo, NPs enhance the therapeutic efficacy of anticancer agents when compared with conventional chemotherapy, improving vectorization and delivery, and helping to overcome drug resistance. Nanomedicine has been mostly focused on solid cancers due to take advantage from the enhanced permeability and retention (EPR) effect experienced by tissues in the close vicinity of tumors, which enhance nanomedicine’s accumulation and, consequently, improve efficacy. Nanomedicines for leukemia and lymphoma, where EPR effect is not a factor, are addressed differently from solid tumors. Nevertheless, NPs have provided innovative approaches to simple and non-invasive methodologies for diagnosis and treatment in liquid tumors. In this review, we consider the state of the art on different types of nanoconstructs for the management of liquid tumors, from preclinical studies to clinical trials. We also discuss the advantages of nanoplatforms for theranostics and the central role played by NPs in this combined strategy.

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Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles

Cited by 131 publications

References 39 publications

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

Mesoporous silica nanoparticles for drug delivery—Recent advances

Nanoparticles—Emerging Potential for Managing Leukemia and Lymphoma

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