Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

Qiu, Liang; Zhao, Linfei; Xing, Chengfen; Ye, Zhan

doi:10.1016/j.cclet.2017.09.048

Cited by 52 publications

(18 citation statements)

References 34 publications

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“…Nowadays the technology of nanoparticles is becoming more and more mature (Fig. 1 c), with different nanoparticles studied extensively including magnetic nanoparticles (Fe 3 O 4 ) [ 36 ], gold nanoparticles [ 37 , 38 ], Ag nanoparticles [ 39 ], silica nanoparticles [ 40 – 44 ], gold/mesoporous silica hybrid nanoparticles (GoMe) [ 45 ], and mesoporous manganese silicate coated silica nanoparticles (MMSSN) [ 46 ]. Among them, mesoporous silica nanoparticles (MSN) have been well studied.…”

Section: Application Of Disulfide Bonds In Redox-responsive Delivery mentioning

confidence: 99%

Advances in redox-responsive drug delivery systems of tumor microenvironment

et al. 2018

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With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed by redox-responsive delivery can be much stable when in circulation. In addition, redox-responsive vectors can respond to the high intracellular level of glutathione and release the loaded cargoes rapidly, only if they reach the site of tumor tissue or targeted cells. Moreover, redox-responsive delivery systems are often applied to significantly improve drug concentrations in targeted cells, increase the therapeutic efficiency and reduce side effects or toxicity of primary drugs. In this review, we focused on the structures and types of current redox-responsive delivery systems and provided a comprehensive overview of relevant researches, in which the disulfide bond containing delivery systems are of the utmost discussion.

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Section: Application Of Disulfide Bonds In Redox-responsive Delivery mentioning

confidence: 99%

Advances in redox-responsive drug delivery systems of tumor microenvironment

et al. 2018

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“…The recent advancements in synthetic chemistry and nanotechnology fostered the development of different nanocarriers for the delivery and controlled release of chemotherapeutic agents (CAs) in tumor cells [ 1 , 2 , 3 , 4 , 5 , 6 ]. Polymeric micelles (PMs), characterized by small size, appreciable drug-loading content (DLC), better accumulation in tumor tissue via “enhanced permeation and retention (EPR) effect”, and the ability to avoid detection and subsequent clearance by the mononuclear phagocyte (MNP) system, are convenient to improve the poor aqueous solubility, slow absorption and non-selective biodistribution of payloads and hence, enhance the therapeutic efficacy of CAs [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Core Crosslinked Polymeric Micelles as Nanocarriers for Doxorubicin Delivery: Self-Assembly, In Situ Diselenide Metathesis and Redox-Responsive Drug Release

et al. 2020

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Polymeric micelles (PMs) have been used to improve the poor aqueous solubility, slow absorption and non-selective biodistribution of chemotherapeutic agents (CAs), albeit, they suffer from disassembly and premature release of payloads in the bloodstream. To alleviate the thermodynamic instability of PMs, different core crosslinking approaches were employed. Herein, we synthesized the poly(ethylene oxide)-b-poly((2-aminoethyl)diselanyl)ethyl l-aspartamide)-b-polycaprolactone (mPEG-P(LA-DSeDEA)-PCL) copolymer which self-assembled into monodispersed nanoscale, 156.57 ± 4.42 nm, core crosslinked micelles (CCMs) through visible light-induced diselenide metathesis reaction between the pendant selenocystamine moieties. The CCMs demonstrated desirable doxorubicin (DOX)-loading content (7.31%) and encapsulation efficiency (42.73%). Both blank and DOX-loaded CCMs (DOX@CCMs) established appreciable colloidal stability in the presence of bovine serum albumin (BSA). The DOX@CCMs showed redox-responsive drug releasing behavior when treated with 5 and 10 mM reduced glutathione (GSH) and 0.1% H2O2. Unlike the DOX-loaded non-crosslinked micelles (DOX@NCMs) which exhibited initial burst release, DOX@CCMs demonstrated a sustained release profile in vitro where 71.7% of the encapsulated DOX was released within 72 h. In addition, the in vitro fluorescent microscope images and flow cytometry analysis confirmed the efficient cellular internalization of DOX@CCMs. The in vitro cytotoxicity test on HaCaT, MDCK, and HeLa cell lines reiterated the cytocompatibility (≥82% cell viability) of the mPEG-P(LA-DSeDEA)-PCL copolymer and DOX@CCMs selectively inhibit the viabilities of 48.85% of HeLa cells as compared to 15.75% of HaCaT and 7.85% of MDCK cells at a maximum dose of 10 µg/mL. Overall, all these appealing attributes make CCMs desirable as nanocarriers for the delivery and controlled release of DOX in tumor cells.

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“…The system was obtained from P[(2-((2-((camptothecin)-oxy)ethyl)disulfanyl) ethylmethacrylate)-co-(2-(D-galactose)methylmethacryl-ate)] P(MACPTS-co-MAGP)@AgNPs nanoparticles and camptothecin (CPT) was linked to the system by disulfide bonds. As shown in Figure 7, in the presence of GSH, the release of the drug is initiated, leading to the fluorescence "turn-on" of CPT [88].…”

Section: Redox-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

Cited by 52 publications

References 34 publications

Advances in redox-responsive drug delivery systems of tumor microenvironment

Advances in redox-responsive drug delivery systems of tumor microenvironment

Fabrication of Core Crosslinked Polymeric Micelles as Nanocarriers for Doxorubicin Delivery: Self-Assembly, In Situ Diselenide Metathesis and Redox-Responsive Drug Release

Smart Nanomaterials for Biomedical Applications—A Review

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