Redox signaling and cancer: The role of “labile” iron

STEAP1 Is Associated with the Invasive and Oxidative Stress Phenotype of Ewing Tumors

“…n.s., nonsignificant. ROS in a site-specific manner depending on the localization of the protein (44,45). As STEAP1 contains a ferric oxidoreductase, it is tempting to speculate that the protein generates ROS by itself (7,42).…”

Germanium nanocrystals as luminescent probes for rapid, sensitive and label-free detection of Fe3+ions

“…Iron is a biologically important and versatile ion and is ubiquitous in living systems, 50 playing a vital role in oxygen uptake, oxygen metabolism and electron transfer in the body. The presence of Fe 3+ in biological systems has to be efficiently monitored as both its deficiency and overloading can induce various biological disorders 51,52 ; hence there is on-going requirement for sensitive sensing strategies for detection of iron. 53 While analytical techniques such as capillary electrophoresis, 54 …”

Determination of Oxide and Reducing Glutathione Levels by Glutathione Peroxidase Activity in Stomach Cancer Patients

“…The inability of GPx to perform this task or the formation of peroxides on its capacity weakens the detoxification power. As a result of this inability, increasing oxidants and genotoxic substances are involved in all stages of chemical carcinogenesis in particular 9,[23][24][25] . In many studies, it has been reported that GPx activity decreases significantly in general, compared with healthy individuals with cancerous tissue and stasis 4,11,26,27 .…”