Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products

Wang, Ming; Sheng, Kang-Jia; Fang, Jia-Cheng; Zhao, Hui; Lu, Si‐Min; Liu, Ziyi; Chen, Bi-Tao

doi:10.1016/j.ejmech.2022.114829

Cited by 7 publications

(3 citation statements)

References 125 publications

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“…TGF-β signaling is an established player in maintaining retinal capillaries, and TGF-β1 has been identified as a contributing factor in the pathogenesis of DR [ 7 , 26 ]. TGF-β1 is known to activate in response to ROS, resulting in the eventual proliferation of endothelial cells, angiogenesis, and blood–retinal barrier disruption [ 27 ]. Inhibition of the TGF-β signaling pathway has been shown to decrease VEGF production following hypoxic states in vitro [ 28 ].…”

Section: Association Of Tgf-β Signaling Pathways In Drmentioning

confidence: 99%

“…However, when these cells were also treated with SIS3, a specific inhibitor of SMAD3, or SB431542, a TGFβR1 antagonist, these results were almost entirely prevented. Not only do these results demonstrate a TGF-β mechanism for acrolein’s damaging effects, but they suggest the value in targeting TGF-β signaling in the treatment of DR [ 27 , 71 ].…”

Section: Current Research On Tgf-β’s Potential Role In Dr Treatmentmentioning

confidence: 99%

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TGF-β Signaling Pathways in the Development of Diabetic Retinopathy

Callan,

Jha,

Valdez

et al. 2024

IJMS

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Diabetic retinopathy (DR), a prevalent complication of diabetes mellitus affecting a significant portion of the global population, has long been viewed primarily as a microvascular disorder. However, emerging evidence suggests that it should be redefined as a neurovascular disease with multifaceted pathogenesis rooted in oxidative stress and advanced glycation end products. The transforming growth factor-β (TGF-β) signaling family has emerged as a major contributor to DR pathogenesis due to its pivotal role in retinal vascular homeostasis, endothelial cell barrier function, and pericyte differentiation. However, the precise roles of TGF-β signaling in DR remain incompletely understood, with conflicting reports on its impact in different stages of the disease. Additionally, the BMP subfamily within the TGF-β superfamily introduces further complexity, with BMPs exhibiting both pro- and anti-angiogenic properties. Furthermore, TGF-β signaling extends beyond the vascular realm, encompassing immune regulation, neuronal survival, and maintenance. The intricate interactions between TGF-β and reactive oxygen species (ROS), non-coding RNAs, and inflammatory mediators have been implicated in the pathogenesis of DR. This review delves into the complex web of signaling pathways orchestrated by the TGF-β superfamily and their involvement in DR. A comprehensive understanding of these pathways may hold the key to developing targeted therapies to halt or mitigate the progression of DR and its devastating consequences.

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Section: Association Of Tgf-β Signaling Pathways In Drmentioning

confidence: 99%

Section: Current Research On Tgf-β’s Potential Role In Dr Treatmentmentioning

confidence: 99%

TGF-β Signaling Pathways in the Development of Diabetic Retinopathy

Callan,

Jha,

Valdez

et al. 2024

IJMS

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“…Early studies have demonstrated the importance of consuming foods that contain substances with antioxidant properties for the prevention of cardiovascular disease, cancer, and age-related degenerative brain disorders [ 104 , 105 , 106 ]. Natural products and plant extracts with antioxidant properties, low toxicity, and known health-promoting properties have been suggested as possible treatments for eye diseases [ 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. Although polyphenols offer several advantages, it is crucial to consider certain factors when evaluating their physiological effects.…”

Section: Dietary Polyphenols: a Potential Strategy For Management Of ...mentioning

confidence: 99%

New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy

et al. 2023

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Diabetic retinopathy (DR) is a neurodegenerative and vascular pathology that is considered one of the leading causes of blindness worldwide, resulting from complications of advanced diabetes mellitus (DM). Current therapies consist of protocols aiming to alleviate the existing clinical signs associated with microvascular alterations limited to the advanced disease stages. In response to the low resolution and limitations of the DR treatment, there is an urgent need to develop more effective alternative therapies to optimize glycemic, vascular, and neuronal parameters, including the reduction in the cellular damage promoted by inflammation and oxidative stress. Recent evidence has shown that dietary polyphenols reduce oxidative and inflammatory parameters of various diseases by modulating multiple cell signaling pathways and gene expression, contributing to the improvement of several chronic diseases, including metabolic and neurodegenerative diseases. However, despite the growing evidence for the bioactivities of phenolic compounds, there is still a lack of data, especially from human studies, on the therapeutic potential of these substances. This review aims to comprehensively describe and clarify the effects of dietary phenolic compounds on the pathophysiological mechanisms involved in DR, especially those of oxidative and inflammatory nature, through evidence from experimental studies. Finally, the review highlights the potential of dietary phenolic compounds as a prophylactic and therapeutic strategy and the need for further clinical studies approaching the efficacy of these substances in DR management.

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Antioxidants in Cardiovascular Disease

Firdous,

Pal

2024

Antioxidants

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Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products

Cited by 7 publications

References 125 publications

TGF-β Signaling Pathways in the Development of Diabetic Retinopathy

TGF-β Signaling Pathways in the Development of Diabetic Retinopathy

New Insights on Dietary Polyphenols for the Management of Oxidative Stress and Neuroinflammation in Diabetic Retinopathy

Antioxidants in Cardiovascular Disease

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