Redox status and sperm characteristics in 1,4-dinitrobenzene-induced reproductive toxicity in Wistar rats

Sangodele, Janet Olayemi; Olaleye, Mary Tolulope; Monsees, Thomas K.; Akinmoladun, Afolabi Clement

doi:10.1007/s13530-017-0298-0

Cited by 6 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the benefits of NPs, several shortfalls have led to potential toxicities in both humans and animals [7]. NPs have been implicated in different ailments, including pulmonary injury, hepatic and renal damage, immuno-nanotoxicity, neurotoxicity, and irreversible testis impairments [8,9]. Reproductive toxicity is increasingly becoming recognized as an important part of overall toxicology [10].…”

Section: Characterization Of the Ag-npmentioning

confidence: 99%

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

et al. 2020

View full text Add to dashboard Cite

The potential pharmaceutical application of nanoparticles has led to the toxicity within the male reproductive system. In the present study, the effects of silver nanoparticles (Ag-NPs) on hematological parameters, free radical generation, antioxidant system, sperm parameters, and organ histo-morphometry in male rats were investigated. Ag-NPs were produced by the reduction of silver ions, while the formation of which was monitored by UV–visible spectrophotometry. Zeta potential, transmission, and scanning electron microscopies were applied for the characterization of AgNPs. A total of 30 rats were divided into 6 groups and were sub-dermally exposed to Ag-NPs at the dosage of 0 (control), 10, and 50 mg/kg bodyweight (bw) doses for either 7 or 28 days. Ag-NP administration altered hematological indices and caused dose-dependent decreases in sperm motility, velocity, kinematic parameters, concentrations of luteinizing hormone, follicle-stimulating hormone, and testosterone. In the epididymis and testis, the concentrations of malondialdehyde and peroxide increases while superoxide dismutase, catalase, reduced glutathione, and total thiol group decreases. These findings suggest that Ag-NP triggered hormonal imbalance and induce oxidative stress in testis and epididymis; which negatively affect sperm parameters of male rats.

show abstract

Section: Characterization Of the Ag-npmentioning

confidence: 99%

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Many investigators have described testicular toxicity associated with an exposure of rats to 1,3-dinitrobenzene or trinitrobenzene (TNB) [7] , [8] , [9] , [10] . It has been reported that in rats DNB cause encephalopathy, hematological alterations and toxicity to brain, testes, epididymis and spleen [11] , [12] , [13] , [14] , [54] .…”

Section: Introductionmentioning

confidence: 99%

The para isomer of dinitrobenzene disrupts redox homeostasis in liver and kidney of male wistar rats

Sangodele

Olaleye

Monsees

et al. 2017

Biochemistry and Biophysics Reports

Self Cite

View full text Add to dashboard Cite

BackgroundPara-Dinitrobenzene (p-DNB) is one of the isomers of dinitrobenzene which have been detected as environmental toxicants. Skin irritation and organ toxicities are likely for industrial workers exposed to p-DNB. This study evaluated the effect of sub-chronic exposure of rats to p-DNB on cellular redox balance, hepatic and renal integrity.MethodsForty eight male Wistar rats weighing 160–180 g were administered 50, 75, 1000 and 2000 mg/kg b.wt (body weight) of p-DNB or an equivalent volume of vehicle (control) orally and topically for 14 days. After the period of treatment, the activities of kidney and liver catalase (CAT), alkaline phosphatase (ALP) and superoxide dismutase (SOD) as well as extent of renal and hepatic lipid peroxidation (LPO) were determined. Serum ALP activity and plasma urea concentration were also evaluated.ResultsCompared with control animals, p-DNB -administered rats showed decrease in the body and relative kidney and liver weights as well as increased renal and hepatic hydrogen peroxide and lipid peroxidation levels accompanied by decreased superoxide dismutase and catalase activities. However, p-DNB caused a significant increase in plasma urea concentration and serum, liver and kidney ALP activities relative to control. In addition, p-DNB caused periportal infiltration, severe macro vesicular steatosis and hepatic necrosis in the liver.ConclusionsOur findings show that sub-chronic oral and sub-dermal administration of p-DNB may produce hepato-nephrotoxicity through oxidative stress.

show abstract

Quantitative analysis of hydrogen peroxide using ratiometric fluorescent probe-doped silica nanoparticles

Kim

Yang

et al. 2017

Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

Redox status and sperm characteristics in 1,4-dinitrobenzene-induced reproductive toxicity in Wistar rats

Cited by 6 publications

References 48 publications

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

Silver Nanoparticles Stimulates Spermatogenesis Impairments and Hematological Alterations in Testis and Epididymis of Male Rats

The para isomer of dinitrobenzene disrupts redox homeostasis in liver and kidney of male wistar rats

Quantitative analysis of hydrogen peroxide using ratiometric fluorescent probe-doped silica nanoparticles

Contact Info

Product

Resources

About