Redox Status in Very-Low Birth-Weight Newborns

Filippi, Luca; Messeri, A.; Dani, Carlo; Pezzati, Marco; Tronchin, Michele; Giani, Tania Santos; Bossoli, S.; Rubaltelli, Firmino F.

doi:10.1159/000075834

Cited by 3 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To evaluate whether TPM can modify the cellular oxidation reduction potential through the inhibition of carbonic anhydrase isoenzymes, 19 we performed at 24 and 48 hours of hypothermia, respectively (after 1 and 2 doses of TPM), a redox status study with measurements of plasma lactate, pyruvate, ß-hydroxybutyrate, and acetoacetate levels on deproteinized arterial blood with spectrophotometric assay (COBAS FARA; Roche, Basel, Switzerland). 20 Clinical Course and Concomitant Treatments A central venous line was placed in all patients. Fluid intake was started at 60 to 70 mL/kg and increased by 10 to 20 mL/ kg each day, on the basis of changes in body weight and serum electrolyte levels.…”

Section: Methodsmentioning

confidence: 99%

Oral Topiramate in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia: A Safety Study

Filippi

Poggi

Marca

et al. 2010

The Journal of Pediatrics

View full text Add to dashboard Cite

Objective To investigate whether topiramate associated with mild or deep hypothermia in asphyxiated term infants is safe in relation to the short-term outcome.Study design We report on 27 consecutive asphyxiated newborns who were treated with whole body hypothermia and 27 additional consecutive newborns with hypothermia who were co-treated with oral topiramate, once a day for 3 consecutive days, at 2 different doses.Results Newborns were divided in 6 groups according to the depth of hypothermia and the association with higher or lower topiramate dosage. A statistical comparison of the groups identified some differences in biochemical and hemodynamic variables, but no adverse effects attributable to topiramate were detected. There were no statistically significant differences in the groups in short-term outcomes, survival rate at discharge, or incidence of pathologic brain magnetic resonance imaging. ConclusionAlthough the number of newborns in this study was limited, the short-term outcome and the safety data appear to support the evaluation of topiramate in clinical trials to explore its possible additive neuroprotective action. (J Pediatr 2010;157:361-6).See editorial, p 351 and related articles, p 367 and p 499 N eonatal hypoxic-ischemic encephalopathy (HIE), caused by perinatal asphyxia, is one of the leading causes of cerebral palsy, the incidence of which has remained essentially unchanged in recent decades despite improvements in perinatal practice and neonatal care.1 Topiramate (TPM), an anticonvulsant agent widely used in adults and children, 2,3 has multiple mechanisms of action, including an inhibitory effect on glutamate receptors. TPM has neuroprotective properties against hypoxic ischemic brain damage, both in vitro and in animal models, and was included in neuroprotective strategies for ischemic stroke 4-11 and neonatal hypoxic-ischemic cerebral injury. 12Several studies have demonstrated the therapeutic effects of whole-body or selective head cooling to treat asphyxiated newborns. [13][14][15] Consequently, mild hypothermia is recommended for the treatment of moderate degrees of encephalopathy. 1 Deep hypothermia may also be safe and neuroprotective. 16 Although TPM logically would be expected to enhance the neuroprotective effects of hypothermia in HIE, no trial has tested this combination treatment.1 Hypothermia can reduce drug clearance, thereby affecting the pharmacokinetics of drugs. 17 In an earlier pilot study, we assessed the effects of mild or deep hypothermia on TPM pharmacokinetics in neonates with HIE. We observed a slow absorption and elimination of TPM. 18 We now report the safety profile of TPM in neonates treated with hypothermia in a retrospective comparison with newborns treated with hypothermia only. MethodsWe studied asphyxiated newborns admitted in 2 neonatal intensive care units

show abstract

Section: Methodsmentioning

confidence: 99%

Oral Topiramate in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia: A Safety Study

Filippi

Poggi

Marca

et al. 2010

The Journal of Pediatrics

View full text Add to dashboard Cite

show abstract

“…ст. [16]. Переход в условия инкубато-ра и искусственной вентиляции сопровождается резким увеличение напряжения кислорода в крови ребенка и появлением в его крови продуктов перекисного окис-ления [16,17].…”

Section: преждевременное прерывание беременностиunclassified

“…[16]. Переход в условия инкубато-ра и искусственной вентиляции сопровождается резким увеличение напряжения кислорода в крови ребенка и появлением в его крови продуктов перекисного окис-ления [16,17]. При этом механизмы антиоксидантной защиты недоношенного ребенка значительно менее раз-виты, чем у доношенного [17], поэтому оксидативный шок и влияние его на процессы метилирования ДНК рассма-тривают как важный эпигенетический фактор [16,17].…”

Section: преждевременное прерывание беременностиunclassified

“…При этом механизмы антиоксидантной защиты недоношенного ребенка значительно менее раз-виты, чем у доношенного [17], поэтому оксидативный шок и влияние его на процессы метилирования ДНК рассма-тривают как важный эпигенетический фактор [16,17]. Продукты перекисного окисления липидов могут моди-фицировать и другие макромолекулы, такие как белки и жиры [16]. Особенно чувствительными к оксидативному шоку оказались компоненты фолатного цикла, синтез ряда аминокислот, таких как метионин, являющийся важ-ным источником метильных групп, необходимых для про-цессов метилирования белков и нуклеиновых кислот [17].…”

Section: преждевременное прерывание беременностиunclassified

See 1 more Smart Citation

Premature Birth and Disease Programming. Contribution of Neonatal Intensive Care

Ковтун¹,

Цывьян²

2014

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

“…Significantly, there is a marked change in the redox state and oxygenation from a relative hypoxic and markedly reduced fetal state to a highly oxygenated extra-uterine life. 12,13 These changes are accompanied by generation of reactive oxygen species (ROS) and consequently changes in metabolism to compensate for the oxidant insult. ROS can cause oxidative modification of major cellular macromolecules, that is, lipids, proteins and DNA.…”

Section: Contributors To Programming: (2) Interruption Of Pregnancymentioning

confidence: 99%

Prematurity and programming: contribution of neonatal Intensive Care Unit interventions

Kalhan

Wilson-Costello

2012

J Dev Orig Health Dis

View full text Add to dashboard Cite

Contemporary clinical practice for the care of the prematurely born babies has markedly improved their rates of survival so that most of these babies are expected to grow up to live a healthy functional life. Since the clinical follow up is of short duration (years), only limited data are available to relate non-communicable diseases in adult life to events and interventions in the neonatal period. The major events that could have a programming effect include (1) Intrauterine growth restriction (2) Interruption of pregnancy with change in redox and reactive oxygen species injury (3) Nutritional and pharmacological protocols for Clinical care (4) Nutritional care in the first two years resulting in accelerated weight gain. The available data are discussed in the context of perturbations in one carbon (methyl transfer) metabolism and its possible programming effects. Although direct evidence for genomic methylation is not available, clinical and experimental data on impact of redox and ROS, of low protein intake, excess methionine load and vitamin A, on methyl transfers are reviewed. The consequences of antenatal and postnatal administration of glucocorticoids are presented. Analysis of the correlates of insulin sensitivity at older age, suggests that premature birth is the major contributor, and is compounded by gain in weight during infancy. We speculate that premature interruption of pregnancy and neonatal interventions by effecting one carbon metabolism may cause programming effects on the immature baby. These can be additive to the effects of intrauterine environment (growth restriction) and are compounded by accelerated growth in early infancy.

show abstract

Redox Status in Very-Low Birth-Weight Newborns

Cited by 3 publications

References 27 publications

Oral Topiramate in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia: A Safety Study

Oral Topiramate in Neonates with Hypoxic Ischemic Encephalopathy Treated with Hypothermia: A Safety Study

Premature Birth and Disease Programming. Contribution of Neonatal Intensive Care

Prematurity and programming: contribution of neonatal Intensive Care Unit interventions

Contact Info

Product

Resources

About