Reduced 18F-sodium fluoride activity in coronary plaques after statin therapy

Dietz, Matthieu; Chironi, Gilles

doi:10.1093/ehjci/jeab016

Cited by 1 publication

(6 citation statements)

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“…Forty-five articles were included in this review [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] ( Figure 1 ), to which were added selected articles on methodological and other aspects. Findings in the articles are summarized in the following sections and in Tables S1–S6 in the Supplementary Material .…”

Section: Resultsmentioning

confidence: 99%

“…Anti-atherosclerotic intervention evaluated by NaF-PET/CT [ 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Resultsmentioning

confidence: 99%

“…Several studies dealt with one arterial bed only, i.e., coronary arteries [ 16 , 17 , 18 , 20 , 29 , 30 , 31 , 38 , 39 , 44 ], global heart [ 22 , 23 , 24 , 25 , 27 , 34 ], pulmonary arteries [ 11 ], left carotid artery [ 28 ], aorta [ 26 , 32 , 41 , 42 , 48 , 49 ], abdominal aorta [ 13 , 33 , 45 ], or several arterial beds [ 5 , 6 , 7 , 8 , 9 , 10 , 12 , 14 , 15 , 21 , 35 , 36 , 37 , 40 , 41 , 43 , 46 , 47 ]. Eight reports were experimental animal studies [ 5 , 6 , 32 , 42 , 43 , 45 , 48 , 49 ], and one was an image case report [ 44 <...…”

Section: Resultsmentioning

confidence: 99%

“…Dietz et al [ 44 ] published an image case story of a 64-year-old asymptomatic male with non-severe hypercholesterolemia and a history of limited smoking during teenage years. The patient was examined by cardiac NaF-PET/CT shown in Figure 3 .…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, total calcium density measured by CT had increased vastly. The human case of Dietz et al [ 44 ] showed unchanged coronary plaques by CT after 6 months on a statin/aspirin and diet/exercise regimen but significantly decreased NaF uptake in these plaques and no new NaF hot spots. Collectively, these data suggest that combinations of statin, exercise, aspirin, and diet may in fact prevent early-phase arterial wall NaF uptake ( Figure 3 ).…”

Section: Discussionmentioning

confidence: 99%

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NaF-PET Imaging of Atherosclerosis Burden

et al. 2023

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The method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of arterial wall macrocalcification detectable by CT. However, this method has not yet found its place in the clinical routine. The more exact association between NaF uptake and future arterial calcification is not fully understood, and it remains unclear to what extent NaF-PET may replace or significantly improve clinical cardiovascular risk scoring. The first 10 years of publications in the field were characterized by heterogeneity at multiple levels, and it is not clear how the method may contribute to triage and management of patients with atherosclerosis, including monitoring effects of anti-atherosclerosis intervention. The present review summarizes findings from the recent 2¾ years including the ability of NaF-PET imaging to assess disease progress and evaluate response to treatment. Despite valuable new information, pertinent questions remain unanswered, not least due to a pronounced lack of standardization within the field and of well-designed long-term studies illuminating the natural history of atherosclerosis and effects of intervention.

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