Reduced acquisition times for measurement of myocardial blood flow with 99mTc-tetrofosmin and solid-state detector SPECT

Do, Jeffrey; Ruddy, Terrence D.; Wells, R. Glenn

doi:10.1007/s12350-020-02048-w

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…The residual activity can be estimated from between 30 and 60 seconds of data. 26 Eliminating the preceding static study reduces MBF acquisition times by another 8 to 10 minutes. Thus, the total increase in time is primarily due to the 2 dynamic acquisitions of 11 minutes each.…”

Section: Discussionmentioning

confidence: 99%

Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time

Wells,

Bengel,

Camoni

et al. 2023

Circ: Cardiovascular Imaging

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Background: Single-center studies have shown that single photon emission computed tomography myocardial blood flow (MBF) measurement is accurate compared with MBF measured with microspheres in a porcine model, positron emission tomography, and angiography. Clinical implementation requires consistency across multiple sites. The study goal is to determine the intersite processing repeatability of single photon emission computed tomography MBF and the additional camera time required. Methods: Five sites (Canada, Italy, Japan, Germany, and Singapore) each acquired 25 to 35 MBF studies at rest and with pharmacological stress using technetium-99m-tetrofosmin on a pinhole-collimated cadmium-zinc-telluride–based cardiac single photon emission computed tomography camera with standardized list-mode imaging and processing protocols. Patients had intermediate to high pretest probability of coronary artery disease. MBF was measured locally and at a core laboratory using commercially available software. The time a room was occupied for an MBF study was compared with that for a standard rest/stress myocardial perfusion study. Results: With motion correction, the overall correlation in MBF between core laboratory and local site was 0.93 (range, 0.87–0.97) at rest, 0.90 (range, 0.84–0.96) at stress, and 0.84 (range, 0.70–0.92) for myocardial flow reserve. The local-to-core difference in global MBF (bias -MBF ) was 5.4% (−3.8% to 14.8%; median [interquartile range]) at rest and 5.4% (−6.2% to 19.4%) at stress. Between the 5 sites, bias -MBF ranged from −1.6% to 11.0% at rest and from −1.9% to 16.3% at stress; the interquartile range in bias -MBF was between 9.3% (4.8%–14.0%) and 22.3% (−10.3% to 12.0%) at rest and between 17.0% (−11.3% to 5.6%) and 33.3% (−10.4% to 22.9%) at stress and was not significantly different between most sites. Both bias and interquartile range were like previously reported interobserver variability and less than the SD of the test-retest difference of 30%. The overall difference in myocardial flow reserve was 1.52% (−10.6% to 11.3%). There were no significant differences between with and without motion correction. The average additional acquisition time varied between sites from 44 to 79 minutes. Conclusions: The average bias -MBF and bias -MFR values were small with standard deviations substantially less than the test-retest variability. This demonstrates that MBF can be measured consistently across multiple sites and further supports that this technique can be reliably implemented. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03427749.

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Section: Discussionmentioning

confidence: 99%

Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time

Wells,

Bengel,

Camoni

et al. 2023

Circ: Cardiovascular Imaging

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“…31 Another factor affecting the accuracy of SPECT MFR is appropriate correction of residual tracer activity resulting from a positioning scan prior to the dynamic imaging or from the first study in a one-day imaging protocol. 32 Finally, the increased MBF variability contributes to elevated MFR variability that does not cancel in the MFR ratio. Short-term test-retest studies are necessary to establish the repeatability of clinical SPECT MFR.…”

Section: Spect Blood Flowmentioning

confidence: 99%

Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications

et al. 2020

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Quantitative analysis has been applied extensively to image processing and interpretation in nuclear cardiology to improve disease diagnosis and risk stratification. This is Part 2 of a two-part continuing medical education article, which will review the potential clinical role for emerging quantitative analysis tools. The article will describe advanced methods for quantifying dyssynchrony, ventricular function and perfusion, and hybrid imaging analysis. This article discusses evolving methods to measure myocardial blood flow with positron emission tomography and single-photon emission computed tomography. Novel quantitative assessments of myocardial viability, microcalcification and in patients with cardiac sarcoidosis and cardiac amyloidosis will also be described. Lastly, we will review the potential role for artificial intelligence to improve image analysis, disease diagnosis, and risk prediction. The potential clinical role for all these novel techniques will be highlighted as well as methods to optimize their implementation. (J Nucl Cardiol 2020)

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“…This progress has translated into shorter scanning time and/or reduced amount of radiopharmaceutical activity administered without loss of image quality compared to conventional techniques. To date, these efforts have focused on positron emission tomography (PET) scans and conventional nuclear medicine, mostly for myocardial investigations [ 1 – 3 ]; little has been done for renal scintigraphy, even though these exams mainly concern pediatric patients who would benefit from shorter scans [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Gamma cameras with cadmium-zinc-telluride (CZT) semiconductor detectors have the potential to reduce acquisition times or the injected activity because of their improved contrast and energy resolution [ 10 ]. Several studies have shown that CZT single-photon emission computed tomography (SPECT), designed for cardiac imaging, is ultrafast [ 1 ]. As such, whole-body SPECT scanning with CZT semiconductor detectors has become commercially available [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrafast cadmium-zinc-telluride-based renal single-photon emission computed tomography: clinical validation

et al. 2023

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Background One of the main limitations of 99mtechnetium-dimercaptosuccinic acid (DMSA) scan is the long acquisition time. Objective To evaluate the feasibility of short DMSA scan acquisition times using a cadmium-zinc-telluride-based single-photon emission computed tomography (SPECT) system in children. Materials and methods The data of 27 children (median age: 4 years; 16 girls) who underwent DMSA SPECT were retrospectively analyzed. Both planar and SPECT DMSA were performed. SPECT images were analyzed using coronal-simulated planar two-dimensional images. A reduction in SPECT acquisition time was simulated to provide 4 series (SPECT-15 min, SPECT-10 min, SPECT-5 min and SPECT-2.5 min). A direct comparison of the planar and SPECT series was performed, including semi-quantification reproducibility, image quality (mean quality score on a scale of 0 to 2) and inter- and intra-observer reproducibility of the scintigraphic patterns. Results The overall image quality score (± standard deviation) was 1.3 (± 0.6) for the planar data set, 1.6 (± 0.5) for the SPECT-15 min data set, 1.4 (± 0.5) for the SPECT-10 min data set, 1.0 (± 0.5) for the SPECT-5 min data set and 0.6 (± 0.6) for the SPECT-2.5 min data set. Median Kappa coefficients for inter-observer agreement between planar and SPECT images were greater than 0.83 for all series and all readers except one reader for the SPECT-2.5 min series (median Kappa coefficient = 0.77). Conclusion Shortening SPECT acquisitions to 5 min is feasible with minimal impact on images in terms of quality and reproducibility. Graphical Abstract

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Reduced acquisition times for measurement of myocardial blood flow with 99mTc-tetrofosmin and solid-state detector SPECT

Cited by 6 publications

References 17 publications

Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time

Multicenter Evaluation of the Feasibility of Clinical Implementation of SPECT Myocardial Blood Flow Measurement: Intersite Variability and Imaging Time

Quantitative clinical nuclear cardiology, part 2: Evolving/emerging applications

Ultrafast cadmium-zinc-telluride-based renal single-photon emission computed tomography: clinical validation

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