Reduced anaerobic and aerobic performance in children with primary ciliary dyskinesia

Simsek, Senem; İnce, Deni̇z İnal; Çakmak, Aslıhan; Emiralioğlu, Nagehan; Çalık-Kütükçü, Ebru; Sağlam, Melda; Vardar-Yağlı, Naciye; Özçelik, Hayriye; Sonbahar-Ulu, Hazal; Bozdemir-Özel, Cemile; Ki̇per, Nural

doi:10.1007/s00431-018-3121-2

Cited by 19 publications

(24 citation statements)

References 29 publications

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“…In our study, the children with PCD demonstrated the lowest knee extensor muscle strength; however, post hoc analysis failed to show a significant difference. Similar to our results, the literature reports that children with PCD have weaker quadriceps muscles than healthy subjects 40 . A study that investigated muscle metabolism of CF, PCD, and healthy subjects revealed that even though metabolic demands and exercise capacities of CF, PCD, and healthy peers are similar; subjects with PCD have poorer work outputs, which was supported by the fact that these patients had the greatest muscle strength impairment 6 .…”

Section: Discussionsupporting

confidence: 90%

Do pulmonary and extrapulmonary features differ among cystic fibrosis, primary ciliary dyskinesia, and healthy children?

Kulli

Gürses

Zeren

et al. 2020

Pediatric Pulmonology

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Background: Primary ciliary dyskinesia (PCD) is generally likened to cystic fibrosis (CF) due to similarities in impaired mucociliary clearance and some other symptoms. The aim of our study was to investigate pulmonary and extrapulmonary characteristics of children with CF and PCD since no studies have addressed respiratory muscle strength in children with PCD and to compare the results to those obtained from healthy age-matched controls. Methods: Pulmonary and extrapulmonary characteristics were assessed by 6-min walk test, spirometry, maximum inspiratory and expiratory pressure measurements, and knee extensor strength test in the children with CF, PCD, and healthy controls. Results: Children with PCD and CF had similar PFT results, except forced expiratory flow between 25% and 75% of vital capacity (FEF 25-75) which was lower in PCD (p = .04). Maximum inspiratory pressure (MIP) value was lower in the children with CF compared with the healthy controls (p = .016), MEP value of the children with PCD was worse than those with CF and healthy controls (p = .013 and p = .013), respectively. 6-min walk test (6MWT) distance of the children with CF was lower than their healthy counterparts (p = .003). Knee extensor muscle strength differed among the children with PCD, CF, and healthy control groups, but post hoc test failed to show statistical significance (p = .010). Conclusion: Children with CF and PCD had some impairments in pulmonary functions, respiratory muscle strength, functional capacity, and peripheral muscle strength compared with healthy children. However, the unique characteristics of each disease should be considered during physiotherapy assessment and treatment. The clinicians may especially focus on the respiratory and peripheral muscle strength of the children with PCD.

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Section: Discussionsupporting

confidence: 90%

Do pulmonary and extrapulmonary features differ among cystic fibrosis, primary ciliary dyskinesia, and healthy children?

Kulli

Gürses

Zeren

et al. 2020

Pediatric Pulmonology

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“…Peripheral muscle strength was found to be decreased in PCD [ 7 , 31 ]. No study investigated the effects of aerobic exercise training on peripheral muscle strength in PCD.…”

Section: Discussionmentioning

confidence: 99%

Active video gaming in primary ciliary dyskinesia: a randomized controlled trial

et al. 2022

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Primary ciliary dyskinesia (PCD) impairs pulmonary function, respiratory and peripheral muscle strength, and exercise capacity. We aimed to investigate the effects of active video games (AVGs) on pulmonary function, respiratory and peripheral muscle strength, exercise capacity, muscle oxygenation (SMO 2 ), physical activity, activities of daily living (ADL), and quality of life (QOL) in PCD. Thirty-two PCD patients were randomly assigned to AVG group ( n = 16) and the control group ( n = 16). AVG group underwent AVGs using Xbox-Kinect-360 device for 40 min/day, 3 days/week for 8 weeks plus airway clearance techniques (ACT), and the control group was applied ACT only. Pulmonary function, respiratory and quadriceps muscle strength, exercise capacity (6-min walk test [6MWT], incremental shuttle walk test [ISWT]), and ADL (Glittre ADL test) were assessed. SMO 2 during ISWT and ADL test was also recorded. Physical activity and QOL (PCD-QOL) were evaluated. Pulmonary function; respiratory and quadriceps muscle strength; 6MWT and ISWT distance; physical activity; ADL performance; SMO 2 ; physical, emotional, and social functioning; treatment burden; and upper and lower symptom parameters of PCD-QOL significantly improved after 8 weeks in the AVG group ( p < 0.05). There were no significant differences in measured parameters except emotional function and upper respiratory symptom scores of PCD-QOL in the control group ( p > 0.05). Conclusion : The AVGs positively affect pulmonary (pulmonary function, respiratory muscle strength) and extrapulmonary (peripheral muscle strength, exercise capacity, SMO 2 , physical activity, ADL, and QOL) characteristics in children with PCD. The AVGs may be added to the pulmonary rehabilitation program as an exercise training modality in patients with PCD. Trial registration : This study registered at ClinicalTrials.gov with NCT03832491 on February 6, 2019. What is Known: • It is indicated that exercise capacity is increased with traditional exercise-training in a case report of Kartagener Syndrome. What is New: • No randomized controlled study investigated the effects of exercise-training in PCD. • 8-week moderate-intensity active video gaming (AVGs) improves pulmonary and extrapulmonary features in children with PCD. AVGs may be preferable due to being enjoyable, providing visual and audial feedback in the pulmonary rehabilitation programs of PCD.

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“…The test was terminated in one of the following conditions: when the participant falls during the test, missed two cones, reached the maximum heart rate, or did not have sufficient physical capacity to continue. 23 Musculoskeletal fitness was evaluated by curl-up for abdominal, 25 push-up for upper extremity, 25 and sit and reach test 25 to indicate the flexibility.…”

Section: Anaerobic Capacitymentioning

confidence: 99%

The comparison of physical fitness and anaerobic capacity in asthmatic and non-asthmatic children

Papurcu

Savcı

Kahraman

et al. 2021

aei

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Introduction and objective: Asthma, is the most common chronic inflammatory disease in childhood period. It can affect the daily life to an advanced level and may become vital. The purpose of this study is to compare physical fitness and anaerobic capacity in asthmatic children (AC) and non-asthmatic children (NC). Materials and methods: A total of 47 children participated in the study; 25 individuals with mild to moderate asthma and 22 healthy children were assessed. The assessed variables consist pulmonary function and peripheral muscle strength (PMS). Additionally, physical fitness was evaluated by using fitnessgram test battery, which includes body composition, modified shuttle walk test (MSWT), curl-up test, push-up test, and sit and reach test variables. Anaerobic capacity was measured with wingate anaerobic capacity test (WAnT) and counter-movement jump (CMJ) using a tri-axial accelerometer. Results: FEV1/FVC ratio (p = 0.01), MSWT (p = 0.001), push-up test (p = 0.01), and WAnT peak power (p = 0.05) were measured significantly to be found reduced in AC compared with that of NC. Between the two groups, PMS, curl-up test, sit and reach test, and CMJ were not significantly different (p = 0.05). High to moderate positive correlation was found among WAnT, CMJ parameters and FEV1, fat-free body mass (FFM), dominant handgrip, and quadriceps strengths (p = 0.05). Conclusions: Physical fitness level and anaerobic capacity were lower in AC compared with that of NC. Physical fitness parameters and anaerobic exercise capacity should be evaluated on the physiotherapy and rehabilitation program in AC.

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Reduced anaerobic and aerobic performance in children with primary ciliary dyskinesia

Cited by 19 publications

References 29 publications

Do pulmonary and extrapulmonary features differ among cystic fibrosis, primary ciliary dyskinesia, and healthy children?

Do pulmonary and extrapulmonary features differ among cystic fibrosis, primary ciliary dyskinesia, and healthy children?

Active video gaming in primary ciliary dyskinesia: a randomized controlled trial

The comparison of physical fitness and anaerobic capacity in asthmatic and non-asthmatic children

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