Reduced Antibody Titers in Mice Treated with Carcinogenic and Cancer Chemotherapeutic Agents

Malmgren, Richard A.; Bennison, B. E.; McKinley, Thomas W.

doi:10.3181/00379727-79-19419

Cited by 110 publications

(20 citation statements)

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“…In contrast, in the present studies, Col did not depress immune responsiveness when injected up to 24 h before assessment of the PFC response ( Figs. 1 and 2), and it has been reported to be immunodepressive in vivo only when injected repeatedly (59,60) or at nearly toxic doses (61,62). In the present work as in previous reports (46,47), Col possessed adjuvant properties at concentrations approaching toxicity, and at concentrations that were toxic for individual animals, the surviving animals exhibited heightened immune responses.…”

Section: Inability Of Col Tosupporting

confidence: 66%

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Parks¹,

Shaller²,

Weigle³

1979

The Journal of Experimental Medicine

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The ability of colchicine (Col) to interfere with suppressor cells specific for the soluble protein antigen human gamma globulin (HGG) has been examined. This interference may be the mechanism of the adjuvanticity promoted by Col. When injected into A/J mice at the appropriate time and concentration, both Col and cyclophosphamide promoted an adjuvant increase in the plaque-forming cell response to 100 micrograms of immunogenic, aggregated HGG. Col abrogated both the induction of suppressor cells when injected with 3 h of tolerization with deaggregated (DHGG) and the expression of previously induced suppressor cells when injected with the antigenic challenge. Interference with the generation and expression of antigen-specific suppressor cells had no detectable effects on the immunologic unresponsive state to HGG. Col did not interfere with the induction of tolerance at a dose (1 mg/kg) that abolished the generation of suppressor cells. Furthermore, the absence of colchicine-sensitive-suppressor cells during the establishment of tolerance had no observable effect on the duration of unresponsivness in either helper T- or B-lymphocyte populations. Finally, Col was not able to terminate the unresponsive state established by DHGG even when responsive splenic B cells could be demonstrated in tolerant animals. These data indicate that suppressor cells are not required for the establishment and maintenance of the unresponsive state to this antigen.

show abstract

Section: Inability Of Col Tosupporting

confidence: 66%

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Parks¹,

Shaller²,

Weigle³

1979

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…The authors state that since immunological function is compromised during (Malmgren et al 1952). The immunosuppressive effects of dibenz [a,h]anthracene were studied in AHH-inducible mice (C57BL/6) and AHH-noninducible mice (DBA/2N) by intraperitoneal and oral administration (Lubet et al 1984).…”

Section: Health Effectsmentioning

confidence: 99%

Urinary polycyclic aromatic hydrocarbons as a biomarker of exposure to PAHs in air: A pilot study among pregnant women

Nethery

Wheeler

Fisher

et al. 2011

J Expo Sci Environ Epidemiol

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“…A growing body of evidence now indicates that substances classifiable as antimetabolites, of which 6-MP may be considered a prototype, are active "anti-immune" agents (11)(12)(13)(14)(15). This activity of these agents may have importance in respect to a widely used tool in the screening of chemotherapeutic agents for the treatment of cancer, namely, the transplantable tumor (16).…”

Section: Discussionmentioning

confidence: 99%

The Effects of 6-Mercaptopurine on Homograft Reactions *

Schwartz¹,

Dameshek²,

Donovan³

1960

J. Clin. Invest.

170

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Reduced Antibody Titers in Mice Treated with Carcinogenic and Cancer Chemotherapeutic Agents

Cited by 110 publications

References 0 publications

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.

Urinary polycyclic aromatic hydrocarbons as a biomarker of exposure to PAHs in air: A pilot study among pregnant women

The Effects of 6-Mercaptopurine on Homograft Reactions *

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