Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion

Abstract

Oxidative stress is one of the main factors for the injury of intact liver lobes during ischaemia-reperfusion.

Iron chelation prevents lung injury after major hepatectomy

“…Liver resection can lead to lung injury through various mechanisms. Hepatic reperfusion causes an oxidative burst in the injured liver, releasing oxidative molecules from the Kupffer cells 1,2,14 . We chose a 150‐min duration of liver ischemia because shorter duration in the swine is not considered to result in injury meaningful for therapeutic interventions 15 .…”

Hemoglobin attenuates the effects of inspired oxygen on plasma isofurans in humans during upper-limb surgery

“…The subsequent oxidative stress is central to, and correlates with, the degree of immune system activation [8]. The intensity of this reaction is proportional to the duration of ischemia, the antioxidant reserve of the patient and the nature of the inflammatory response [9]. Later involvement of components of the immune system plays a downstream role and contributes to the local and systemic inflammatory responses [10].…”

Protective effects of simvastatin administered in the experimental hepatic ischemia-reperfusion injury rat model

“…Therefore, we investigated the optimal dose of SV which Therefore, MDA is a useful quantitative indicator of LPO [22]. In this study, hepatic I/R caused significant LPO accumulation compared with the sham group.…”