Reduced anxiety and depression in cystic acne patients after successful treatment with oral isotretinoin

Rubinow, David R.; Peck, Gary L.; Squillace, Kathleen M.; Gantt, Gail G.

doi:10.1016/s0190-9622(87)70166-2

Cited by 217 publications

(150 citation statements)

References 11 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…Improvement in Self-Image Resulting from Acne Treatment: Some have argued that treatment of acne with isotretinoin leads to an improvement in self image and therefore a reduction in depression. Studies have reported improvement in feelings of general well-being or self image (Cassileth et al 1982;Gupta et al 1990;Shuster et al 1978), or feelings of anxiety in patients with cystic acne following isotretinoin administration (Garrie and Garrie 1978;Gupta et al 1990;Jacobs et al 2001;Kellett and Gawkrodger 1999;Marqueling and Zane 2005;Medansky et al 1981;Rubinow et al 1987;Van der Meeren et al 1985). In general, these findings support the action of isotretinoin to improve the patient's self-image and satisfaction with treatment, however these are not indicators of an absence of clinical symptoms of depression.…”

Section: Data From Public Governmental Agency Reportsmentioning

confidence: 99%

The neurobiology of retinoic acid in affective disorders

Bremner

McCaffery

2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

147

154

View full text Add to dashboard Cite

Current models of affective disorders implicate alterations in norepinephrine, serotonin, dopamine, and CRF/cortisol; however treatments targeted at these neurotransmitters or hormones have led to imperfect resolution of symptoms, suggesting that the neurobiology of affective disorders is incompletely understood. Until now retinoids have not been considered as possible contributors to affective disorders. Retinoids represent a family of compounds derived from Vitamin A that perform a large number of functions, many via the vitamin A product, retinoic acid. This signaling molecule binds to specific retinoic acid receptors in the brain which, like the glucocorticoid and thyroid hormone receptors, are part of the nuclear receptor superfamily and regulate gene transcription. Research in the field of retinoic acid in the CNS has focused on the developing brain, in part stimulated by the observation that isotretinoin (13-cis retinoic acid), an isomer of retinoic acid used in the treatment of acne, is highly teratogenic for the CNS. More recent work has suggested that retinoic acid may influence the adult brain; animal studies indicated that the administration of isotretinoin is associated with alterations in behavior as well as inhibition of neurogenesis in the hippocampus. Clinical evidence for an association between retinoids and depression includes case reports in the literature, studies of health care databases, and other sources. A preliminary PET study in human subjects showed that isotretinoin was associated with a decrease in orbitofrontal metabolism. Several studies have shown that the molecular components required for retinoic acid signaling are expressed in the adult brain ; the overlap of brain areas implicated in retinoic acid function and stress and depression suggest that retinoids could play a role in affective disorders. This report reviews the evidence in this area and describes several systems that may be targets of retinoic acid and which contribute to the pathophysiology of depression.

show abstract

Section: Data From Public Governmental Agency Reportsmentioning

confidence: 99%

The neurobiology of retinoic acid in affective disorders

Bremner

McCaffery

2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

147

154

View full text Add to dashboard Cite

show abstract

“…15,16 Increased awareness and early intervention for the psychological and psychiatric sequelae of acne can benefit patients.…”

Section: Introductionmentioning

confidence: 99%

Acne and Quality of Life- A Study from a Tertiary Care Centre in South India

Samanthula¹

2013

IOSR-JDMS

View full text Add to dashboard Cite

“…The purpose of the present study was to determine the prevalence of acne with an objective acne grading scale, and to evaluate the levels of emotional, social, and functional impairment among Korean adolescents with acne using age-appropriate and wellvalidated generic measures of psychiatric status. To prove effective clinical care with adjunctive psychotherapy is thought to be mandatory for maintenance or restoration of psychological well-being, and some of the psychological effects can be reversed by effective clinical intervention with psychological encouragement 8 . It is thus essential to uncover those at risk of experiencing a psychologic problem and to identify variables predicting this impairment.…”

Section: Introductionmentioning

confidence: 99%