Reduced Arginine Bioavailability in Sepsis.

Gough,; Morgan, M.Naunton; Mack, CM; Darling, DC; Frasier, LM; Doolin, KP; Apostolakos, Michael J.; Arning, Erland; Mooney, Robert A.; Frampton, MW; Pietropaoli, AP

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1157

Cited by 2 publications

(3 citation statements)

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“…The goal of this study was to determine if these estimates of systemic arginine availability are reduced in patients with severe sepsis and septic shock and associated with severity of illness and outcomes. Some of the results of this study have been reported previously in abstract form (16). …”

Section: Introductionsupporting

confidence: 58%

The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis*

Gough

Morgan

Mack

et al. 2011

Critical Care Medicine

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Objective-Arginine deficiency may contribute to microvascular dysfunction, but previous studies suggest that arginine supplementation may be harmful in sepsis. Systemic arginine availability can be estimated by measuring the ratio of arginine to its endogenous inhibitors, asymmetric and symmetric dimethylarginine. We hypothesized that the arginine to dimethylarginine (Arg/DMA) ratio is reduced in patients with severe sepsis and associated with severity of illness and outcomes.Design-Case-control and prospective cohort study This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptCrit Care Med. Author manuscript; available in PMC 2012 June 1. Conclusions-The Arg/DMA ratio is associated with severe sepsis, severity of illness, and clinical outcomes. The Arg/DMA ratio may be a useful biomarker, and interventions designed to augment systemic arginine availability in severe sepsis may still be worthy of investigation.

show abstract

Section: Introductionsupporting

confidence: 58%

The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis*

Gough

Morgan

Mack

et al. 2011

Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…The presence of cardiovascular disease was designated if there was a documented medical history of any of the following: coronary artery disease, stroke, peripheral vascular disease, or congestive heart failure. .51 Methionine, mmol/L 20 (14-29) 20 (17)(18)(19)(20)(21)(22)(23)(24)(25)(26) .76 Homocysteine, mmol/L 4 (3-6) 6 (5-7) .02…”

Section: Resultsmentioning

confidence: 99%

“…The study design and the clinical characteristics and outcomes of the study participants have been described previously. [23][24][25] Consecutive patients admitted to the medical or surgical intensive care units at the University of Rochester Medical Center from February 2006 through May 2008 were screened for enrollment. Patients were eligible if they met the prevailing diagnostic criteria for severe sepsis or septic shock 26 (collectively referred to hereafter as sepsis 27 ).…”

Section: Methodsmentioning

confidence: 99%