Reduced Ascending Aortic Strain and Distensibility

Redheuil, Alban; Yu, Wen Chung; Wu, Colin O.; Mousseaux, Élie; Cesare, Alain De; Yan, Raymond T.; Kachenoura, Nadjia; Bluemke, David A.; Lima, João A.C.

doi:10.1161/hypertensionaha.109.141275

Cited by 325 publications

(234 citation statements)

References 31 publications

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“…40,41 An association reported between carotid-femoral pulse wave velocity and HR 7,42 has been attributed to fatigue failure of elastin fibers; 43 however in common with another MRI study, we did not observe a relationship between HR and aortic PWV. 23 The physiological mechanisms linking body fat with arterial stiffness are not fully understood, although several possibilities have been proposed. 44 Even short-term weight gain can alter arterial stiffness, and a plausible explanation is that changes in insulin sensitivity, activation of the renin-angiotensin system, sympathetic nervous system activation, and modulation of smooth muscle tone are influential factors.…”

Section: Discussionmentioning

confidence: 99%

“…22 Assessment of the vascular phenotype using PWV enables subclinical vascular disease to be quantified even before the onset of systemic hypertension. 23,24 Although the association between obesity and adult cardiovascular disease has been extensively studied, there are fewer data available on the subclinical effects of elevated body fat on early vascular disease in overtly healthy subjects. In this study, we aimed to investigate a population without known cardiovascular disease and assess the effect of body composition on the relationship between aging and aortic PWV.…”

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confidence: 99%

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Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

et al. 2013

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Abstract-Obesity is a major risk factor for cardiometabolic disease, but the effect of body composition on vascular aging and arterial stiffness remains uncertain. We investigated relationships among body composition, blood pressure, age, and aortic pulse wave velocity in healthy individuals. Pulse wave velocity in the thoracic aorta, an indicator of central arterial stiffness, was measured in 221 volunteers (range, 18-72 years; mean, 40.3±13 years) who had no history of cardiovascular disease using cardiovascular MRI. In univariate analyses, age (r=0.78; P<0.001) and blood pressure (r=0.41; P<0.001) showed a strong positive association with pulse wave velocity. In multivariate analysis, after adjustment for age, sex, and mean arterial blood pressure, elevated body fat% was associated with reduced aortic stiffness until the age of 50 years, thereafter adiposity had an increasingly positive association with aortic stiffness (β=0.16; P<0.001). Body fat% was positively associated with cardiac output when age, sex, height, and absolute lean mass were adjusted for (β=0.23; P=0.002). These findings suggest that the cardiovascular system of young adults may be capable of adapting to the state of obesity and that an adverse association between body fat and aortic stiffness is only apparent in later life. (Hypertension. 2013;61:1322-1327.)

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

et al. 2013

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“…Nevertheless, the wide age range of the included subjects (7-77 years) made it possible to assess aortic elasticity at different ages, given the well-known reduction of aortic distensibility even with normal ageing. [1]. Moreover, due to the design of the proposed algorithm, an enlarged aortic lumen of an elderly man would have been easier to segment than a healthy child's aorta, which is more elastic.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Monitoring cardiovascular disease progression from subclinical changes to advanced stages is crucial for the definition of a target population to apply preventive strategies and perform longitudinal studies [1,2]. Structural and functional changes in the aortic wall can induce arterial stiffness, which is correlated with hypertension, associated with hearth failure, and is a major predictor of stroke and myocardial infarction [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Fully automated contour detection of the ascending aorta in cardiac 2D phase-contrast MRI

Codari

Scarabello

Secchi

et al. 2018

Magnetic Resonance Imaging

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Purpose: In this study we proposed a fully automated method for localizing and segmenting the ascending aortic lumen with phase-contrast magnetic resonance imaging (PC-MRI). Material and Methods:Twenty-five phase-contrast series were randomly selected out of a large population dataset of patients whose cardiac MRI examination, performed from September 2008 to October 2013, was unremarkable. The local Ethics Committee approved this retrospective study.The ascending aorta was automatically identified on each phase of the cardiac cycle using a priori knowledge of aortic geometry. The frame that maximized the area, eccentricity, and solidity parameters was chosen for unsupervised initialization. Aortic segmentation was performed on each frame using active contouring without edges techniques. The entire algorithm was developed using Matlab R2016b. To validate the proposed method, the manual segmentation performed by a highly experienced operator was used. Dice similarity coefficient, Bland-Altman analysis, and Pearson's correlation coefficient were used as performance metrics. Results:Comparing automated and manual segmentation of the aortic lumen on 714 images, Bland-Altman analysis showed a bias of -6.68 mm 2 , a coefficient of repeatability of 91.22 mm 2 , a mean area measurement of 581.40 mm 2 , and a reproducibility of 85%. Automated and manual segmentation were highly correlated (R = 0.98). The Dice similarity coefficient versus the manual reference standard was 94.6 ± 2.1% (mean ± standard deviation). Conclusion:A fully automated and robust method for identification and segmentation of ascending aorta on PC-MRI was developed. Its application on patients with a variety of pathologic conditions is advisable.

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“…Mounting evidence supports the adverse effect of preterm birth, and more so very preterm birth (<32 weeks gestational age), on cardiovascular health 1, 2. Individuals born preterm display both structural and functional cardiovascular alterations, which include higher blood pressure,2 microvasculature rarefaction,3, 4 increased vascular resistance,5 as well as changes in heart shape and function,6, 7, 8 which are independent harbingers of hypertension and cardiovascular disease 9, 10. Given that rates of preterm birth have increased along with improved survival, it is expected that the absolute number of adults born preterm, and therefore at risk of developing cardiovascular disease, will escalate in the future.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease

Bertagnolli

Xie

Paquette

et al. 2018

JAHA

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BackgroundPreterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development and repair. Cord blood endothelial progenitor cells of preterm‐born infants, especially endothelial colony‐forming cells (ECFC), show enhanced susceptibility to prematurity‐related pro‐oxidant stress. Whether ECFC dysfunction is present in adulthood following preterm birth is unknown.Methods and ResultsThis cross‐sectional observational study includes 55 preterm‐born (≤29 gestational weeks) young adults (18–29 years old, 38% male) and 55 sex‐ and age‐matched full‐term controls. ECFC were isolated from peripheral blood; cell proliferative and vascular cord formation capacities were assessed in vitro. Daytime systolic blood pressure was higher, whereas glucose tolerance and body mass index were lower in preterm‐born subjects. ECFC colonies grew in culture for 62% of full‐term‐ and 58% of preterm‐born participants. Preterm‐born participants have formed ECFC colonies later in culture and have reduced proliferation compared with controls. Only in preterm‐born individuals, we observed that the later the ECFC colony grows in culture, the worse was overall ECFC function. In addition, in preterms, elevated systolic blood pressure significantly correlated with reduced ECFC proliferation (rS=−0.463; P=0.030) and numbers of branches formed on matrigel (rS=−0.443; P=0.039). In preterm‐born subjects, bronchopulmonary dysplasia was associated with impaired ECFC function, whereas exposure to antenatal steroids related to better ECFC function.ConclusionsThis study is the first to examine ECFC in preterm‐born adults and to demonstrate ECFC dysfunction compared with full‐term controls. In the preterm‐born group, ECFC dysfunction was associated with bronchopulmonary dysplasia, the major prematurity‐related neonatal morbidity, and with increased systolic blood pressure into adulthood.

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Reduced Ascending Aortic Strain and Distensibility

Cited by 325 publications

References 31 publications

Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

Fully automated contour detection of the ascending aorta in cardiac 2D phase-contrast MRI

Endothelial Colony‐Forming Cells in Young Adults Born Preterm: A Novel Link Between Neonatal Complications and Adult Risks for Cardiovascular Disease

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