Reduced bile acid excretion is an independent risk factor for stroke and mortality: A prospective follow-up study

Charach, Gideon; Karniel, Eli; Novikov, Ilya; Galin, Leonid; Vons, Shely; Grosskopf, Itamar; Charach, Lior

doi:10.1016/j.atherosclerosis.2019.12.010

Cited by 40 publications

(44 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Failure to effectively excrete BAs may be an independent risk factor for CAD (20). In addition, in a long-term follow-up study of BA excretion, stroke incidence, and mortality, the decrease in BAs and secondary BA excretion was related to the risk of stroke, which pointed towards an association between atherosclerosis and BA excretion as an independent risk factor for cerebrovascular disease (21). The excretion of BAs as an indicator of CAD prognosis does not have quantitative standard references, and the prognostic value of TBA level for CAD has remained unclear.…”

Section: Relationship Between Ba Excretion and Prognosismentioning

confidence: 99%

Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids

et al. 2021

View full text Add to dashboard Cite

BackgroundAs metabolic molecules, bile acids (BAs) not only promote the absorption of fat-soluble nutrients, but they also regulate many metabolic processes, including the homeostasis of glucose and lipids. Although total serum BA (TBA) measurement is a readily available clinical test related to coronary artery disease (CAD), myocardial infarction (MI), and type 2 diabetes mellitus (T2DM), the relationship between TBA and these pathological conditions remain unclear, and research on this topic is inconclusive.MethodsThis study enrolled 20,255 menopausal women aged over 50 years, including 6,421 T2DM patients. The study population was divided into different groups according to the median TBA level in order to explore the clinical characteristics of menopausal women with different TBA levels. Spline analyses, generalized additive model (GAM) model and regression analyses based on TBA level were used to explore the relationship between TBA and different diseases independently, including CAD and MI, or in combination with T2DM.ResultsBoth in the general population and in the T2DM subgroup, the TBA level was significantly lower in CAD patients than in non-CAD patients. Spline analyses indicated that within normal clinical range of TBA concentration (0–10 µmol/L), the presence of CAD and MI showed similar trends in total and T2DM population. Similarly, the GAM model indicated that within the 0–10 μmol/L clinical range, the predicted probability for CAD and MI alone and in combination with T2DM was negatively correlated with TBA concentration. Multivariate regression analysis suggested that low TBA level was positively associated with the occurrence of CAD combined with T2DM (OR: 1.451; 95%CI: 1.141–1.847).ConclusionsIn menopausal women, TBA may represent a valuable clinical serum marker with negative correlation for CAD and MI in patients with T2DM.

show abstract

Section: Relationship Between Ba Excretion and Prognosismentioning

confidence: 99%

Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Interestingly, a recent study which assessed fecal BA and blood lipid profile of male volunteers with hyper-cholesterolemia and normo-cholesterolemia failed to find significant difference in BA concentrations between these two groups, though a trend toward increased DCA and CA was observed in the former cohort of patients [33]. Another retrospective follow-up study revealed that in total BA excretion, DCA and LCA were positively related to high density lipoprotein cholesterol level and were found to be an independent risk factor for ischemic stroke [34]. Our preliminary finding highlights the need to take into account not only differences in body mass index [35] and dietary changes [36], as already described, but also cholesterol levels when investigating pathophysiological changes of BA.…”

Section: Discussionmentioning

confidence: 96%

Bile Acids Quantification by Liquid Chromatography–Tandem Mass Spectrometry: Method Validation, Reference Range, and Interference Study

et al. 2020

View full text Add to dashboard Cite

Bile acids (BA) play a pivotal role in cholesterol metabolism. Their blood concentration has also been proposed as new prognostic and diagnostic indicator of hepatobiliary, intestinal, and cardiovascular disease. Liquid chromatography tandem mass spectrometry (LC–MS/MS) currently represents the gold standard for analysis of BA profile in biological samples. We report here development and validation of a LC–MS/MS technique for simultaneously quantifying 15 BA species in serum samples. We also established a reference range for adult healthy subjects (n = 130) and performed a preliminary evaluation of in vitro and in vivo interference. The method displayed good linearity, with high regression coefficients (>0.99) over a range of 5 ng/mL (lower limit of quantification, LLOQ) and 5000 ng/mL for all analytes tested. The accuracies were between 85–115%. Both intra- and inter-assay imprecision was <10%. The recoveries ranged between 92–110%. Each of the tested BA species (assessed on three concentrations) were stable for 15 days at room temperature, 4 °C, and −20 °C. The in vitro study did not reveal any interference from triglycerides, bilirubin, or cell-free hemoglobin. The in vivo interference study showed that pools obtained from hyper-cholesterolemic patients and hyper-bilirubinemic patients due to post-hepatic jaundice for benign cholestasis, cholangiocarcinoma and pancreatic head tumors had clearly distinct patterns of BA concentrations compared with a pool obtained from samples of healthy subjects. In conclusion, this study proposes a new suitable candidate method for identification and quantitation of BA in biological samples and provides new insight into a number of variables that should be taken into account when investigating pathophysiological changes of BA in human diseases.

show abstract

“…Moreover, patients with TBA levels lower than 3.6 μmol/L had a significantly twofold higher prevalence of CAD and MI than those with TBA levels above 3.6 μmol/L but below the upper normal limit. Characha et al [22] investigated the association of BAE with cerebral artery atherosclerosis in 103 patients, who were admitted under suspicion of CAD because of chest pain, and followed up for 20 years. Stool samples were collected for 24h after provision of 225 mg copper isothiocyanate as a fecal flow marker.…”

Section: Lipid-related Biomarkers Beyond Cholesterol and Triglyceridesmentioning

confidence: 99%

The year 2020 in Atherosclerosis

Binder¹,

Borén²,

Catapano³

et al. 2021

Atherosclerosis

View full text Add to dashboard Cite

Reduced bile acid excretion is an independent risk factor for stroke and mortality: A prospective follow-up study

Cited by 40 publications

References 23 publications

Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids

Myocardial Infarction and Coronary Artery Disease in Menopausal Women With Type 2 Diabetes Mellitus Negatively Correlate With Total Serum Bile Acids

Bile Acids Quantification by Liquid Chromatography–Tandem Mass Spectrometry: Method Validation, Reference Range, and Interference Study

The year 2020 in Atherosclerosis

Contact Info

Product

Resources

About