Reduced blood loss during Caesarean section under the action of tranexamic acid

Does tranexamic acid prevent postpartum haemorrhage? A systematic review of randomised controlled trials

“…We identified 31 reports describing 26 trials involving a total of 4191 women (Figure S1). The trial reports were published between 2001 and 2015.…”

Prophylactic use of tranexamic acid reduces blood loss and transfusion requirements in patients undergoing cesarean section: A meta‐analysis

“…Seven trial registrations without sufficient data for analysis were also excluded. Finally, 21 studies (19 research papers and 2 conference abstracts) with 3852 patients were eligible for our analysis. Figure shows the details of study selection and inclusion.…”

“…Seven studies without placebo control groups were considered with high risk of performance bias, while four studies] had an unclear risk in performance bias for lack of clear descriptions of blinding of participants and personnel. For selection bias, six studies without descriptions of randomization methods and two studies without details of the selection criteria were considered with unclear bias. For detection bias, nine studies with insufficient information of blinding of outcome assessment were thought to have unclear bias.…”

“…However, there is still a controversy about the prophylactic application of TXA to patients undergoing CS. Thus, we identified all available randomized controlled trials (RCT), totally 21, to evaluate whether preoperative administration of TXA has potential effects on reducing blood loss as well as transfusion requirements for patients undergoing CS. Moreover, we also investigated the impact of TXA on other factors associated with bleeding, including hemoglobin and hematocrit drops, additional uterotonic agent use (oxytocin and methylergometrine) and massive hemorrhage rate.…”

A systematic review and meta‐analysis of the effect of prophylactic tranexamic acid treatment in major benign uterine surgery

“…Thus, a total of 16 trials were finally included in the present review. Fourteen studies [21][22][23][24][25][26][27][28][29][30][31][32][33][34] involved women undergoing elective CD and two studies 35,36 involved women having abdominal myomectomy (Table 1). No studies involving hysterectomy were identified.…”