Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in <i>Drosophila</i>

Kim, Mari; Son, Gwang-Ic; Cho, Yun-Ho; Kim, Gye-Hyeong; Yun, Sung-Eun; Kim, Young-Joon; Chung, Jongkyeong; Lee, Eunil; Park, Joong Jean

doi:10.1080/01677063.2022.2144292

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Altered circadian rhythm has been associated with SCA in several studies. (Kim, Lim, et al, 2021; Motolese et al, 2020; Petsakou et al, 2015; Pfeffer et al, 2017; Tsimpanouli, Ghimire, Barget, Weston, Costa, et al, 2022; Tsimpanouli, Ghimire, Barget, Weston, Paulson, et al, 2022). Type 3 SCA transgenic mice, show increased fragmentation in all sleep and wakefulness states, larger oscillations of beta power during REM and non‐REM sleep, indicating that common sleep‐related etiological factors may underlie the SCA3 phenotypes of mice (Tsimpanouli, Ghimire, Barget, Weston, Paulson, et al, 2022).…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

“…Nevertheless, reduced CLOCK and BMAL1 expression levels were found in dermal fibroblasts derived from type 17 SCA patients (Motolese et al, 2020). Furthermore, a recent study by Kim, Lim, et al (2021)) showed that the expansion of polyglutamine repeats in Ataxin‐1, a gene linked to SCA type 1, leads to disrupted circadian rhythms in Drosophila, which may contribute to disease pathogenesis. These differences in gene expression found by the studies may be because SCA comprises a heterogeneous group of subtypes depending on the locus or causative gene.…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

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Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

Canever

Queiroz

SOARES

et al. 2023

Journal of Neurochemistry

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The circadian rhythm is a nearly 24‐h oscillation found in various physiological processes in the human brain and body that is regulated by environmental and genetic factors. It is responsible for maintaining body homeostasis and it is critical for essential functions, such as metabolic regulation and memory consolidation. Dysregulation in the circadian rhythm can negatively impact human health, resulting in cardiovascular and metabolic diseases, psychiatric disorders, and premature death. Emerging evidence points to a relationship between the dysregulation circadian rhythm and neurodegenerative diseases, suggesting that the alterations in circadian function might play crucial roles in the pathogenesis and progression of neurodegenerative diseases. Better understanding this association is of paramount importance to expand the knowledge on the pathophysiology of neurodegenerative diseases, as well as, to provide potential targets for the development of new interventions based on the dysregulation of circadian rhythm. Here we review the latest findings on dysregulation of circadian rhythm alterations in Parkinson's disease, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, spinocerebellar ataxia and multiple‐system atrophy, focusing on research published in the last 3 years.image

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Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

Canever

Queiroz

SOARES

et al. 2023

Journal of Neurochemistry

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Editorial/preface: Neurogenetics innovation in South Korea

Wang

Suh

2023

Journal of Neurogenetics

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Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods

Ajayi

Wynne

Chen

et al. 2023

Integrative and Comparative Biology

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Understanding the biology of blood-feeding arthropods is critical to managing them as vectors of etiological agents. Circadian rhythms act in the regulation of behavioral and physiological aspects such as blood feeding, immunity, and reproduction. However, the impact of sleep on these processes has been largely ignored in blood-feeding arthropods, but recent studies in mosquitoes show that sleep-like states directly impact host landing and blood feeding. Our focus in this review is to discuss the relationship between sleep and circadian rhythms in blood-feeding arthropods along with how unique aspects such as blood gluttony and dormancy can impact sleep-like states. We highlight that sleep-like states are likely to have profound impacts on vector-host interactions but will vary between lineages even though few direct studies have been conducted. A myriad of factors, such as artificial light, could directly impact the time and levels of sleep in blood-feeding arthropods and their roles as vectors. Lastly, we discuss underlying factors that make sleep studies in blood-feeding arthropods difficult and how these can be bypassed. As sleep is a critical factor in the fitness of animal systems, a lack of focus on sleep in blood-feeding arthropods represents a significant oversight in understanding their behavior and its role in pathogen transmission.

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Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila

Cited by 6 publications

References 46 publications

Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

Circadian rhythm alterations affecting the pathology of neurodegenerative diseases

Editorial/preface: Neurogenetics innovation in South Korea

Sleep: An Essential and Understudied Process in the Biology of Blood-Feeding Arthropods

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