Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma

Abstract

CitationReduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma. 2011, 128 (1):50-5 J. Allergy Clin. Immunol.

Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation

“…Despite the publication of a joint ATS/ERS task force document on methodological considerations, many questions are not yet properly resolved [137]. EBC collection in preschool children is of particular interest as the measurement of selected exhaled markers may allow distinction between different phenotypes of wheezing [137][138][139]. However, the collection procedure in children younger than 4 years of age may be more difficult due to the lower level of cooperation and smaller amounts of EBC.…”

Predicting who will have asthma at school age among preschool children

“…60 Addition of the API to measurement of the exhaled breath condensate pH improved its performance substantially in discriminating atopic and nonatopic 5-year-olds with wheeze. 61 Fifth, better characterization of the genetic risk might improve the prediction of asthma. Although common genetic variants performed poorly in the prediction of asthma in children, 62 a personal genomic risk profile that also includes gene expression profiles, gene-gene and gene-environment interactions, and regulatory and epigenetic effects might together help to determine whether a child is at increased risk for asthma development.…”

Advances in pediatric asthma in 2011: Moving forward

“…Von Jagwitz et al 92 reported that a reduced, deaerated, exhaled breath condensate pH value might help identify asymptomatic children at high risk for asthma. A readily available biomarker is exhaled nitric oxide, and there are now American Thoracic Society guidelines for its clinical application.…”