Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine

Kostowski, Wojciech; Gumułka, W.; Członkowski, Andrzej

doi:10.1016/0006-8993(72)90208-9

Cited by 121 publications

(16 citation statements)

References 9 publications

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“…The results presented in this paper, however, confirmed our previous observations (25) and indicated that an intact and func tionally unimpaired serotoninergic system is necessary for the development of cataleptogenic actions o f neuroleptics. Both CPZ and haloperidol are known to increase the synthesis rate o f brain 5-HT (7,14,15).…”

Section: Discussionsupporting

confidence: 79%

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Role of 5-HT in the Action of Some Drugs Affecting Extrapyramidal System

1973

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The effects of drugs influencing the function of extrapyramidal system: chlorpromazine (CPZ), halo peridol, amphetamine, and oxotremorine were checked in rats with lesioned MR or DR raphe areas and in animals pretreated with either p-CPA (p-chlorophenylalanine) or LSD, i.e. at impaired functions of the central serotoninergic system. Lesions of the raphe system and pretreatment with either p-CPA or LSD significantly diminished the cataleptogenic effects of both CPZ and haloperidol. The amphetamine-induced stereotyped behaviour was intensified in animals with raphe system lesions, whereas in rats pretreated with p-CPA or LSD the action of amphetamine was diminished. Rats with raphe system lesions showed no change in the tremorogenic action of oxotremorine. In animals pretreated with either p-CPA or LSD the onset of the oxotremorine tremor was even delayed. It is concluded that an intact and functionally unimpaired serotoninergic system is necessary for the cataleptogenic action of neuroleptics.

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Section: Discussionsupporting

confidence: 79%

“…In a previous paper (25) we reported a decreased cataleptogenic activity of both chlorpromazine (CPZ) and haloperidol in rats pretreated with p-CPA or animals with lesioned raphe nuclei, i.e. with impaired function of the cerebral serotoninergic system (21,24).…”

mentioning

confidence: 99%

Role of 5-HT in the Action of Some Drugs Affecting Extrapyramidal System

1973

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“…Serotonergic mechanisms have been noted to affect the extrapyramidal motor functions. Antipsychotic drug-induced catalepsy is attenuated by decreasing serotonergic transmissions (Carter and Pycock, 1977;Kostowski et al, 1972). Conversely, it is potentiated by increasing 5-HT transmissions (Carter and Pycock, 1977).…”

Section: Discussionmentioning

confidence: 97%

Characterization of [3H]clozapine binding sites in rat brain

Kusumi

Matsubara

Takahashi

et al. 1995

J. Neural Transmission

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We examined the characteristics of [3H]clozapine binding sites in four rat brain regions (frontal cortex, limbic area, hippocampus and striatum) in order to elucidate the pharmacological profile of this unique atypical antipsychotic drug. The specific [3H]clozapine binding was found to be saturable and reversible in all these brain regions. Scatchard analysis of the saturation data indicated that the specific binding consisted of high- and low-affinity components. Displacement experiments showed that the muscarinic cholinergic receptor represented about 50% of [3H]clozapine binding in each brain area. Serotonin 5-HT2 and dopamine D4 receptor binding sites could also be detected by displacement experiments using ketanserin and nemonapride, respectively, in frontal cortex and limbic area, but not in hippocampus or striatum. Alpha-1, alpha-2, histamine H1, dopamine D1, D2, or D3 receptor components could not be determined within the high-affinity [3H]clozapine binding sites in any brain region. It is possible that the atypical property of clozapine may depend on the modulatory effect on dopaminergic function via 5-HT2 receptor blockade and/or may be mediated via D4 receptor blockade in the mesocortical and mesolimbic area.

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“…There is ample evidence to suggest the existence of parallel S-HT and DA neuron pathways in the striatal regions of the mammalian brain (Davies & Tongroach, 1978) and homologous areas of the avian brain (Juorio & Vogt, 1967), which are known to participate in psychomotor functions such as catalepsy. Furthermore, the putative S-RT agonist quipazine has been shown to block the cataleptic state produced by haloperidol, a well-known DA antagonist (Grabowska, Antkiewicz, & Michaluk, 1974), and S-HT depletion by p-chlorophenylalanine (PCP A) or raphe lesions has been found to block such haloperidol-induced catalepsy (Kostowski, Gumulka, & Czlonkowski, 1972). In addi-…”

Section: Salem College Salem West Virginiamentioning

confidence: 99%

The effect of spiroperidol on tonic immobility in domestic fowl

Hennig

Spencer

1983

Bull. Psychon. Soc.

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Six groups of 2.5-week-old chickens were injected with either distilled water, 1 % lactic acid, or various dosages of spiroperidol (.02, .2, 2, and 20 mg/kg). The largest dose of this drug significantly reduced the general activity of the subjects. Spiroperidol also produced dose-dependent enhancement of tonic immobility durations, but had no apparent effect on the number of inductions required to elicit the immobility response. These results are discussed in terms of serotonergic and dopaminergic involvement with tonic immobility.

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Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine

Cited by 121 publications

References 9 publications

Role of 5-HT in the Action of Some Drugs Affecting Extrapyramidal System

Role of 5-HT in the Action of Some Drugs Affecting Extrapyramidal System

Characterization of [3H]clozapine binding sites in rat brain

The effect of spiroperidol on tonic immobility in domestic fowl

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