Reduced Caudate Nucleus Volume in Obsessive-compulsive Disorder

Robinson, Delbert G.; Wu, Houwei; Munne, Rafael; Ashtari, Manzar; Alvir, José; Lerner, Gail; Koreen, A.; Cole, Karyl; Bogerts, Bernhard

doi:10.1001/archpsyc.1995.03950170067009

Cited by 297 publications

(140 citation statements)

References 21 publications

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“…This may be especially problematic in cases where structural abnormalities and/or increased variability are present. For instance, abnormalities of caudate volume have been inconsistently reported in OCD (see Robinson et al 1995;Rauch and Baxter 1998); resulting mis-registration involving the caudate in the current study could underlie our failure to find significant effects in this region.…”

Section: Discussionmentioning

confidence: 61%

Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study

Rauch

2002

Neuropsychopharmacology

161

108

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The purpose of this study was to identify neuroimaging predictors of medication response in contamination-related obsessive compulsive disorder (OCD). Prior studies of OCD had indicated that glucose metabolic rates within orbitofrontal cortex (OFC) were inversely correlated with subsequent response to serotonergic reuptake inhibitors (SRIs) and that glucose metabolic rates within posterior cingulate cortex (PCC) Functional imaging research has contributed substantially to contemporary neurocircuitry models of obsessive compulsive disorder (OCD) (Rauch 2000;Rauch and Baxter 1998;Saxena et al. 1998 PET Predictors of Fluxoamine Response in OCD 783OCD. These areas exhibit hyperactivity at rest that is accentuated during symptom provocation and attenuated following successful treatment.One promising clinical application of neuroimaging is to identify predictors of treatment response. Three prospective studies of OCD patients have already found that pre-treatment positron emission tomography (PET) measurements of cerebral metabolic rates within OFC significantly predict subsequent response to treatment with serotonergic reuptake inhibitors (SRIs) Saxena et al. 1999;Swedo et al. 1992). Specifically, lower pre-treatment rates of metabolism within OFC have consistently been associated with better subsequent responses to SRIs. Conversely, in one of these reports , higher cerebral metabolic rates within left OFC were associated with better responses to behavioral therapy.Recently, an initial study was conducted examining PET cerebral metabolic correlates as potential predictors of response to anterior cingulotomy in patients with OCD (Rauch et al. 2001b). Rauch and colleagues found that higher cerebral metabolic rates within posterior cingulate cortex (PCC) were associated with better subsequent response to cingulotomy. However, the cingulotomy study differed from previous studies of SRIs in that statistical parametric mapping rather than region of interest (ROI)-based methods of data analysis were used. Therefore, it remained unclear whether the unique findings regarding the PCC were indicative of: (1) the difference in treatment type (i.e., cingulotomy vs. SRIs); (2) the difference in data analytic methods (i.e., statistical parametric mapping vs. ROI-based); or (3) differences in the patient groups studied (i.e., severe treatment-refractory patients on medications vs. a conventional sample of patients with OCD, off medications).In the current study, we sought to build on the previous body of research in this area. Specifically, we sought to study PET predictors of SRI treatment response using statistical parametric mapping methods. Moreover, we employed a symptom provocation design, so that we could compare the profiles of PET predictors of treatment response during a provoked symptomatic state versus a neutral state. Thus, we tested the a priori hypotheses that lower rCBF within OFC and higher rCBF within PCC would be associated with better subsequent response to SRIs. Moreover, we were able to investigate whether ...

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Section: Discussionmentioning

confidence: 61%

Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study

Rauch

2002

Neuropsychopharmacology

161

108

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“…Pediatric OCD is associated with smaller striatum structures (caudate and putamen) (Rosenberg et al 1997b) and a selective deficit in frontostriatal function (Rosenberg et al 1997a) in medication naive subjects. Striatal abnormalities are also seen in adult OCD (Modell et al 1989;Robinson et al 1995). Recently, significantly smaller bilateral orbital frontal and amygdala volumes, as well as a lack of the normal hemispheric asymmetry of the hippocampus-amygdala complex, were found in adult OCD (Szeszko et al 1999).…”

Section: Discussionmentioning

confidence: 99%

A pilot study of amygdala volumes in pediatric generalized anxiety disorder

Bellis

Casey

Dahl

et al. 2000

Biological Psychiatry

304

196

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“…The intensity of the left-side motor symptoms was associated with cleanliness worries, repetitions, and disturbing thoughts, whereas the severity of right-sided symptoms was significantly related only to obsessions with order and routine. Despite the fact that some neuroimaging studies have shown differences between the two hemispheres 25,26,27,28 , evidence regarding lateralized pathophysiology in OCD is inconclusive as yet.…”

Section: Ocd and Parkinson's Diseasementioning

confidence: 99%

“…In addition to anatomic connections, neuroimaging studies have suggested the participation of the basal ganglia in the pathophysiology of OCD. Several studies using both cranial tomography and magnetic resonance imaging have shown the loss of the asymmetry normally observed in caudate nuclei, the left being larger than the right, in patients with OCD or TS 25,26,27,28 . On the other hand, other authors have shown a reduction in size of the lenticular nucleus (globus pallidus and putamen) in magnetic resonance imaging of patients with TS, however without a change in the caudate volume 46,47 .…”

Section: The Basal Ganglia and The Pathophysiology Of Ocdmentioning

confidence: 99%

Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia

et al. 1999

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Obsessive-compulsive disorder (OCD) has been reported in association with some neurological diseases that affect the basal ganglia such as Tourette's syndrome, Sydenham's chorea, Parkinson's disease, and Huntington's disease. Furthermore, studies such as neuroimaging, suggest a role of the basal ganglia in the pathophysiology of OCD. The aim of this paper is to describe the association of OCD and several neurologic disorders affecting the basal ganglia, report the existing evidences of the role of the basal ganglia in the pathophysiology of OCD, and analyze the mechanisms probably involved in this pathophysiology.

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Reduced Caudate Nucleus Volume in Obsessive-compulsive Disorder

Abstract: Our findings provide additional evidence for pathological involvement of the caudate in OCD.

Cited by 297 publications

References 21 publications

Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study

Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study

A pilot study of amygdala volumes in pediatric generalized anxiety disorder

Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia

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