Reduced competition between tool action neighbors in left hemisphere stroke

Garcea, Frank E.; Stoll, Harrison; Buxbaum, Laurel J.

doi:10.1016/j.cortex.2019.05.021

Cited by 16 publications

(27 citation statements)

References 90 publications

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“…Furthermore, lesions involving the inferior parietal lobule and adjacent voxels overlapping with the SLF are associated with poor tool use gesturing in apraxia ( Bi et al. 2015 ; Watson and Buxbaum 2015 ; Garcea, Stoll, et al. 2019 ), suggesting that sensory-to-motor mapping in the action domain may be underpinned in part the SLF (for discussion of the SLF/AF and its role in other cognitive domains, see Catani and Mesulam 2008 ; Dick et al.…”

Section: Discussionmentioning

confidence: 99%

“…(1991) , if a participant gestured the action as if their hand was the tool (body-part-as-object error), they were reminded to “show how you would use the tool as if you were actually holding it in your hand.” The first of these errors was corrected and the participant was permitted a second try (for precedent, see Tarhan et al. 2015 ; Watson and Buxbaum 2015 ; Garcea, Stoll, et al. 2019 ).…”

Section: Methodsmentioning

confidence: 99%

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Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

Garcea

Greene

Grafton

et al. 2020

Cerebral Cortex Communications

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Producing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory-motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory-motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue, and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection among the left inferior parietal lobule, lateral and ventral temporal cortex, and middle and superior frontal gyri predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, largely bypassing regions supporting tool use gesturing. Our findings provide causal evidence that limb apraxia may arise, in part, from a disconnection between conceptual representations in the temporal lobe and mechanisms enabling skilled action production in the inferior parietal lobule.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

Garcea

Greene

Grafton

et al. 2020

Cerebral Cortex Communications

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“…As per Rothi et al (1991), if a participant gestured the action as if their hand was the tool (body-part-as-object error), they were reminded to "show how you would use the tool as if you were actually holding it in your hand". The first of these errors was corrected and the participant was permitted a second try (for precedent, see Garcea, Stoll, et al, 2019;Tarhan et al, 2015;.…”

Section: Neuropsychological Testing Of Tool Use Gesturing and Meaningmentioning

confidence: 99%

“…Voxelwise z-scores were then computed for the true data in relation to the mean and standard deviation of voxelwise null distributions; the resulting z-score map was set to a threshold of z > 1.65 (p < .05, one-tailed) to determine chance-level likelihood of a lesion-symptom relation. We then further restricted the resulting map by eliminating any clusters with fewer than 500 contiguous voxels (see Garcea, Stoll, et al, 2019;Lacey et al, 2017;Skipper-Kallal et al, 2017). The Anatomical Automatic Labeling (AAL) atlas (Tzourio-Mazoyer et al, 2002) was used to assess overlap of significant voxels in the SVR-VLSM analyses with cortical and subcortical regions.…”

Section: Neuroimaging Acquisitionmentioning

confidence: 99%

“…Given prior evidence that lesions involving the white matter adjacent Disconnection in the Tool Use Network Following Stroke 34 to the inferior frontal gyrus (uncinate fasciculus, left inferior fronto-occipital fasciculus, anterior thalamic radiations) were associated with impaired selection of verbal and non-verbal conceptual knowledge (e.g., see Mirman, Chen, et al, 2015; see also Han et al, 2013), it remains a possibility that the ventral fiber pathway supports tool action selection. However, given that current lesion evidence suggests that action selection in tool use is mediated by fronto-parietal structures via the SLF (e.g., see Garcea, Stoll, et al, 2019;, it will be important for future VLSM and CLSM work to determine the extent to which damage to the ventral fiber pathway, controlling for damage of SLF fibers, is associated with action selection difficulties.…”

Section: Implications For Neurocognitive Models Of Praxis In the Humamentioning

confidence: 99%

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Structural Disconnection of the Tool Use Network After Left Hemisphere Stroke Predicts Limb Apraxia Severity

Garcea

Greene

Grafton

et al. 2020

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Producing a tool use gesture is a complex process drawing upon the integration of stored knowledge of tools and their associated actions with sensory-motor mechanisms supporting the planning and control of hand and arm actions. Understanding how sensory-motor systems in parietal cortex interface with semantic representations of actions and objects in the temporal lobe remains a critical issue, and is hypothesized to be a key determinant of the severity of limb apraxia, a deficit in producing skilled action after left hemisphere stroke. We used voxel-based and connectome-based lesion symptom mapping with data from 57 left hemisphere stroke participants to assess the lesion sites and structural disconnection patterns associated with poor tool use gesturing. We found that structural disconnection between the left inferior parietal lobule, lateral temporal lobe (left middle temporal gyrus) and ventral temporal cortex (left medial fusiform gyrus) predicted the severity of tool use gesturing performance. Control analyses demonstrated that reductions in right-hand grip strength were associated with motor system disconnection, bypassing regions supporting tool use gesturing. Our findings provide causal evidence that limb apraxia may arise, in part, from disconnection of conceptual representations in the temporal lobe from mechanisms enabling skilled action production in the inferior parietal lobule.

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Lesion-Symptom Mapping: From Single Cases to the Human Disconnectome

Forkel¹

2022

Encyclopedia of Behavioral Neuroscience, 2nd Edition

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Reduced competition between tool action neighbors in left hemisphere stroke

Cited by 16 publications

References 90 publications

Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

Structural Disconnection of the Tool Use Network after Left Hemisphere Stroke Predicts Limb Apraxia Severity

Structural Disconnection of the Tool Use Network After Left Hemisphere Stroke Predicts Limb Apraxia Severity

Lesion-Symptom Mapping: From Single Cases to the Human Disconnectome

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