Reduced Corneal Thickness Values in Postmenopausal Women With Dry Eye

Sanchis‐Gimeno, Juan A.; Lleó-Pérez, A.; Alonso, Luis Martı́nez; Rahhal, M.S.; Martı́nez-Soriano, Francisco

doi:10.1097/01.ico.0000138836.45070.0f

Cited by 42 publications

(39 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Although there is little documentation about the CCT changes in postmenopausal women, SanchisGimeno JA et al demonstrated that CCT was lower in postmenopausal women with dry eye symptoms compared to postmenopausal women without dry eye symptoms. 13 This finding suggests that, in postmenopausal women, dry eye may also has an additional effect on the decrease in CCT. A randomized controlled study investigating menopausal women indicated that no significant corneal curvature changes were detected between premenopausal and postmenopausal women and estrogen established a significant negative correlation with horizontal curvature in postmenopausal women but estrogen did not correlate with the corneal curvature changes in premenopausal women and progesterone did not correlate with the corneal curvature changes both in pre-and postmenopausal women.…”

Section: Discussionmentioning

confidence: 68%

Effects of menopause on corneal topography and dry eye

Turgut

Dolgun

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: The aim of this study was to investigate the effect of estrogen and progesterone on central corneal thickness, corneal curvature, and the development of dry eye in postmenopausal women.Methods: This is a case-control study including 54 premenopausal and 54 postmenopausal women. The two groups were compared in terms of follicle stimulating hormone, estradiol, progesterone, and horizontal and vertical curvatures, astigmatism, central corneal thickness, Schirmer I test scores, and dry eye scores of both eyes.Results: In the postmenopausal women, central corneal thickness was significantly thinner in both eyes (p=0.017) and the Schirmer test scores were significantly lower both for the right (p=0.001) and the left eye (p=0.003). Estradiol levels were positively correlated with central corneal thickness (p=0.003-0.006) and Schirmer test scores (p=0.004-0.002) whereas progesterone levels showed a positive correlation only with Schirmer test scores (p=0.036-0.044). Although a significant positive correlation was found between estradiol levels and dry eye scores (p=0,009), no significant correlation was found between progesterone levels and dry eye scores (p=0,118).Conclusions: Age-related hormonal abnormalities lead to central corneal thinning, increased dry eye symptoms, and decreased tear flow, particularly in the postmenopausal term. Decreased estrogen levels are associated with central corneal thickness and dry-eye symptoms, decreased estrogen and progesterone levels correlates well with diminished tear production but progesterone levels does not effect dry-eye symptoms.

show abstract

Section: Discussionmentioning

confidence: 68%

Effects of menopause on corneal topography and dry eye

Turgut

Dolgun

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…As such, to our knowledge, this is the first study that evaluates the proliferative response to desiccating stress and the thickening of the corneal epithelium, and suggests that abnormally rapid tissue turnover and hyperplasia is a common response to the epithelial “stress response” throughout the entire ocular surface. Previous studies in humans have focused on total corneal, not just epithelial, thickness, and have reported a reduction in central corneal thickness in Sjögren’s and non Sjögren’s dry eye; in these studies the central thickness of the corneal epithelium did not change (Erdélyi et al, 2007; Tuominen et al, 2003) or was not evaluated (Liu and Pflugfelder, 1999; Sanchis-Gimeno et al, 2005; Villani et al, 2007). …”

Section: Discussionmentioning

confidence: 99%

Corneal epithelial proliferation and thickness in a mouse model of dry eye

Fabiani

Barabino

Rashid

et al. 2009

Experimental Eye Research

View full text Add to dashboard Cite

Although several studies have previously focused on the conjunctival epithelial response to surface dryness, little is known about the effect of a dry environment on corneal epithelium, which is the most clinically significant tissue affected in dry eye. The aim of this study was to quantitatively evaluate the effect of desiccating stress on the number of proliferating corneal epithelial cells and corneal epithelial thickness in mice placed in a controlled-environment chamber (CEC) that induces dry eye.Corneal epithelial cell proliferation and thickness were studied in 8-12 week old female BALB/c mice placed in the CEC (temperature: 22.3 ± 0.7°C; relative humidity: 22.5 ± 4.5%; airflow: 15 L/ min) for 7 days and compared to a control group of mice with no dry eye. Actively proliferating cells were identified by immunofluorescence using a FITC-conjugated antibody against the Ki-67 protein, a cell proliferation marker expressed during active phases of the cell cycle. To detect the spatial distribution of proliferative cells, Ki-67 + cells were counted in three areas of the epithelium: center, periphery, and limbus. Corneal epithelial thickness was evaluated in the central cornea after staining with hematoxylin-eosin. Results from each experimental group were compared using the MannWhitney test.The number of Ki-67 + cells observed in the corneal epithelium of mice exposed to the CEC was significantly higher in each area (center: 32.1 ± 1.1; periphery: 94.2 ± 5.3; limbus: 4.0 ± 1.5) than in the control group (center: 13.2 ± 1.0, p = 0.02; periphery: 42.9 ± 2.3, p = 0.02; limbus: 0.0, p = 0.01). In mice subjected to desiccating stress, a significant number of Ki-67 + positive cells were detected in the basal and suprabasal cell layers (central area 46%; periphery 30.8%: limbus 0%), whereas in the control group the cells were exclusively distributed through the basal cell layer. Ki-67 + cells were not found in the corneal stroma or endothelium in any group. The corneal epithelium was found to be significantly thicker in dry eye mice (54.94 ± 6.09 μm) as compared to the controls (43.9 ± 6.23 μm: p < 0.0001) by a mean of 25%.These results demonstrate that desiccating stress increases corneal epithelial turnover and thickness, similar to what is observed in other chronic inflammatory states of other epithelialized surfaces. The CEC can facilitate the study of the regulation of epithelial cell function and turnover at the molecular and cellular levels under desiccating stress conditions.

show abstract

“…11 We enrolled the control subjects, who were at similar age and have similar distribution of sex with the RA group, and Scheimpflug imaging was performed preceding the corneal staining. In addition, there was no significant effect of age or gender on any of the pachymetric [15][16][17] Some other studies demonstrate thickening in cornea following artificial tears or topical cyclosporine-A treatments. 18,19 Villani et al 9 found the corneas of RA patients to be significantly thinner than those of control subjects in their in vivo confocal study.…”

Section: Discussionmentioning

confidence: 95%