Reduced corpus callosum white matter microstructural integrity revealed by diffusion tensor eigenvalues in abstinent methamphetamine addicts

Kim, In-Sung; Kim, Yang-Tae; Song, Hyohak; Lee, Jaejun; Kwon, Dohoon; Lee, Hui Joong; Kim, Myoung-Nam; Yoo, Done-Sik; Chang, Yongmin

doi:10.1016/j.neuro.2008.12.002

Cited by 39 publications

(42 citation statements)

References 34 publications

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“…A few DTI studies on MA users reported WM changes in corpus callosum (Kim et al 2009;Salo et al 2009) and frontal lobe (Alicata et al 2009;Chung et al 2007;Tobias et al 2010), which were not found in the present study. The inconsistency could be caused by different demographic and drug use profiles.…”

Section: Discussioncontrasting

confidence: 89%

“…The inconsistency could be caused by different demographic and drug use profiles. Kim et al (2009) andTobias et al's (2010) studies included MA subjects who just abstained from MA for less than 1 month, whereas our subjects had abstained for 6 month even at baseline scan.…”

Section: Discussionmentioning

confidence: 93%

“…Secondly, only male subjects were recruited due to the treatment settings were separated for male and female compulsory drug rehabilitation centers in Shanghai. The gender effect on MA-related brain damage was a controversy highlighted in previous studies (Chung et al 2007;Kim et al 2009;Salo et al 2009;Tobias et al 2010). Thirdly, the sample size is relatively small.…”

Section: Discussionmentioning

confidence: 94%

“…WM fills nearly half of the human brain, provides connections between regional or distant areas (Fields 2008b), and plays a critical role in cognition and learning (Fields 2008a). Cross-sectional diffusion tensor imaging (DTI) studies have revealed that microstructural abnormalities in fronto-striatal network (Alicata et al 2009;Chung et al 2007;Lyoo et al 2015;Tobias et al 2010) and corpus callosum (Kim et al 2009;Salo et al 2009;Tobias et al 2010) in chronic MA users were associated with cognitive function impairments (Chung et al 2007;Kim et al 2009) or clinical symptoms (Lederer et al 2016;Tobias et al 2010). Uhlmann et al (2016) reported a positive correlation between WM integrity and MA abstinence time in several major WM tracts.…”

Section: Introductionmentioning

confidence: 99%

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Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study

Zhuang

Tang

Zhong

et al. 2016

J Neuroimmune Pharmacol

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White matter (WM) alterations have been reported in methamphetamine (MA) users. However, knowledge about longitudinal changes in WM during abstinence from MA remains unknown. The present study aimed to examine how WM changes in long-term MA abstinent, in particular, whether the WM deficits would recover as the duration of abstinence extended. Twenty male MA dependent individuals and 19 healthy controls (HCs) were recruited and participated in both clinical assessments and diffusion tensor imaging (DTI) scans. The MA group underwent two DTI scans, a baseline scan with a duration of abstinence of 6.4 months and and a follow-up scan with a duration of abstinence of 13.0 months. Tract-Based Spatial Statistics was utilized to conduct baseline DTI analysis of MA group compared with HCs. The clusters with significant group differences of factional anisotropy (FA) were extracted as region of interests (ROIs). Mean values of DTI measurements (FA, mean diffusivity, axial diffusivity and radial diffusivity) were calculated within the ROIs in each subject's native space at baseline and follow-up. The MA group showed significant lower FA in the right internal capsule and superior corona radiate than HCs. The deficits did not recover when the duration of abstinence from MA reached 13 months. No significant correlations were found between FA and clinical measurements. Our results suggested persistent microstructure deficits of WM tracts surrounding the basal ganglia in MA dependent individuals.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study

Zhuang

Tang

Zhong

et al. 2016

J Neuroimmune Pharmacol

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“…DTI changes associated with METH abuse or dependence have commonly revealed lower FA in frontal white matter and increased MD in basal ganglia structures, such as the putamen and caudate (Alicata et al, 2009; Chung et al, 2007; Tobias et al, 2010). Differences in the integrity of the corpus callosum are less often found, with some investigators reporting lower FA values in the genu (Kim et al, 2009; Tobias et al, 2010), whereas others report only trends or no callosal effect (Alicata et al, 2009; Salo et al, 2009). When cognition is investigated, lower FA in regions within the frontal cortex or genu has been associated with worse cognitive performance (Chung et al, 2007; Salo et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging

McKenna

Brown

Archibald

et al. 2016

Psychiatry Research: Neuroimaging

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Methamphetamine (METH) is an addictive psychostimulant inducing neurotoxicity. Human magnetic resonance imaging and diffusion tensor imaging (DTI) of METH-dependent participants find various structural abnormities. Animal studies demonstrate immunohistochemical changes in multiple cellular pathways after METH exposure. Here, we characterized the long-term effects of METH on brain microstructure in mice exposed to an escalating METH binge regimen using in vivo DTI, a methodology directly translatable across species. Results revealed four patterns of differential fractional anisotropy (FA) and mean diffusivity (MD) response when comparing METH-exposed (n=14) to saline-treated mice (n=13). Compared to the saline group, METH-exposed mice demonstrated: 1) decreased FA with no change in MD [corpus callosum (posterior forceps), internal capsule (left), thalamus (medial aspects), midbrain], 2) increased MD with no change in FA [posterior isocortical regions, caudate-putamen, hypothalamus, cerebral peduncle, internal capsule (right)], 3) increased FA with decreased MD [frontal isocortex, corpus callosum (genu)], and 4) increased FA with no change or increased MD [hippocampi, amygdala, lateral thalamus]. MD was negatively associated with calbindin-1 in hippocampi and positively with dopamine transporter in caudate-putamen. These findings highlight distributed and differential METH effects within the brain suggesting several distinct mechanisms. Such mechanisms likely change brain tissue differentially dependent upon neural location.

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Anatomical and Neurochemical Evidence of Neurotoxic Changes in Psychostimulant Abuse and Dependence

Sung¹,

Renshaw²

2011

Neuroimaging in Addiction

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Reduced corpus callosum white matter microstructural integrity revealed by diffusion tensor eigenvalues in abstinent methamphetamine addicts

Cited by 39 publications

References 34 publications

Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study

Persistent Microstructural Deficits of Internal Capsule in One-Year Abstinent Male Methamphetamine Users: a Longitudinal Diffusion Tensor Imaging Study

Microstructural changes to the brain of mice after methamphetamine exposure as identified with diffusion tensor imaging

Anatomical and Neurochemical Evidence of Neurotoxic Changes in Psychostimulant Abuse and Dependence

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