Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men

Herieka, Mohammed; Faraj, Tola Abdulsattar; Erridge, Clett

doi:10.1016/j.numecd.2015.12.001

Cited by 24 publications

(23 citation statements)

References 30 publications

(42 reference statements)

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“…Several studies have shown the association between the DII score and inflammatory biomarkers, including the rate of telomere shortening [20,21,22,23]. In a longitudinal analysis of 559 healthy participants, higher DII scores were associated with values of high-sensitivity(hs)-CRP greater than 3 mg/L [23].…”

Section: The Dietary Inflammatory Index (Dii) Scorementioning

confidence: 99%

“…In fact, the inverse association of a Mediterranean-style diet with major chronic disease is partially attributed to the anti-inflammatory properties of some of their foods such as fruits, extra-virgin olive oil, red wine, or nuts [16,17], and some of their bioactive components, such as polyphenols [18]. In contrast, certain components of diet, such as red meat and processed foods, are considered to be pro-inflammatory stimulants [19,20]. …”

Section: Introductionmentioning

confidence: 99%

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The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

Ruiz‐Canela

Bes–Rastrollo

Martínez‐González

2016

IJMS

147

102

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Inflammation is an underlying pathophysiological process in chronic diseases, such as obesity, type 2 diabetes mellitus and cardiovascular disease. In fact, a number of systematic reviews have shown the association between inflammatory biomarkers, such as CRP, IL-1β, IL-6, TNF-α, IL-4, or IL-10, and cardio-metabolic diseases. Diet is one of the main lifestyle-related factors which modulates the inflammatory process. Different individual foods and dietary patterns can have a beneficial health effect associated with their anti-inflammatory properties. The dietary inflammatory index (DII) was recently developed to estimate the inflammatory potential of overall diet. The aim of this review is to examine the findings of recent papers that have investigated the association between the DII, cardio-metabolic risk factors and cardiovascular disease. The relevance of the DII score in the association between inflammation and cardio-metabolic diseases is critically appraised, as well as its role in the context of healthy dietary patterns. We conclude that the DII score seems to be a useful tool to appraise the inflammatory capacity of the diet and to better understand the relationships between diet, inflammation, and cardio-metabolic diseases.

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Section: The Dietary Inflammatory Index (Dii) Scorementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

Ruiz‐Canela

Bes–Rastrollo

Martínez‐González

2016

IJMS

147

102

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“…The amount of TLR2 and 4 stimulants in food extracts is found to promote insulin resistance and atherosclerosis in an animal model and correlated with their capacity to induce TNF-α (Erridge 2011). In a more recent study, he demonstrated that the pro-inflammatory stimulants of TLR2 and 4 in some processed foods were associated with the risk of cardiometabolic diseases (Erridge et al 2016). In addition, bacterial polysaccharides identified in eatable plants such as apple or ginseng were found to interact also with TLR4 .…”

Section: Processed Food Containing Microbial Stimulantsmentioning

confidence: 99%

Micronutrients and many important factors that affect the physiological functions of toll-like receptors

2019

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Background: Toll-like receptors (TLRs) are type I integral transmembrane receptors involved in recognition and conveying of pathogens to the immune system. These receptors are located either on cell surfaces or within endosomes. They are activated by specific ligand leading to the release of cytokines via signal transduction pathway. The excess production of these cytokines leads to disrupt the immune homeostasis. There are several factors regulating TLR expression and consequently affecting their functions. Among these are inflammation, cytokines, some cellular process, air pollution, depression, stress, some drugs, genetic polymorphism, nutrition, and micronutrients. Some micronutrients (vitamins and trace elements) may be considered as important TLR regulators, as they have immunomodulatory functions. Vitamins D, B12, and A; zinc; copper; and iron have important role on innate immune responses. Aim of work: This review gives a brief idea on TLR family and attempts to cover the factors affecting the physiological functions of them. Conclusion: Of many factors affecting TLRs functions are micronutrients. There is a shortage of researches concerning the effect of micronutrients deficiency on the function of TLRs, all of which focused on vitamin D but other vitamins have not got the same importance that they deserve. This orients our efforts to work at this point in the future.

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“…Furthermore, diet-induced inflammation could be mediated partly by the PAMPs (pathogen associated molecular patterns) produced by microbes in processed foods [71]. PAMPs, (e.g.…”

Section: Other Components Of the Western Diet That Influence Inflammamentioning

confidence: 99%

“…As these PAMPs are heat stable, they can be present after heat treatment in food products with seemingly good microbiological quality [72]. A study of human volunteers reported reduction in white blood cell count, LDL cholesterol, body weight and waist circumference after one week on a diet low in PAMPs, whereas the beneficial changes were reversed by a diet high in PAMPs [71]. If these effects are corroborated by more studies, then the quality assessment of industrial food products should include analyses for LPS and other toll-like receptor stimulants to avoid inflammatory responses in the host, and improved measures should be taken to limit growth of PAMP-producing bacteria during processing.…”

Section: Other Components Of the Western Diet That Influence Inflammamentioning

confidence: 99%

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

Zinöcker¹,

Lindseth²

2018

Preprint

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Abstract:The dietary pattern that characterizes the Western diet is strongly associated with obesity and related metabolic diseases, but biological mechanisms supporting these associations remain largely unknown. We argue that the Western diet is promoting inflammation that arises from both structural and behavioral changes in the resident microbiome. The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease. Recognizing the importance of the microbiome in the development of diet-related disease has implications for future research, public dietary advice as well as food production practices. Research into food patterns suggest that whole foods is a common denominator of diets associated with a low level of diet-related disease. Hence, by studying how ultra-processing changes properties of whole foods and how these foods affect the gut microbiome, more useful dietary guidelines can be made. Innovations in food production should be focusing on enabling health in the super-organism of man and microbe, and stronger regulation of potentially hazardous components of food products is warranted.

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Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men

Abstract: 1Background and aims: Because pro-inflammatory stimulants of Toll-like receptor-2 and

Cited by 24 publications

References 30 publications

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

Micronutrients and many important factors that affect the physiological functions of toll-like receptors

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease

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Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men

Abstract: 1Background and aims: Because pro-inflammatory stimulants of Toll-like receptor-2 and

Cited by 24 publications

References 30 publications

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

Micronutrients and many important factors that affect the physiological functions of toll-like receptors

The Western Diet&ndash;Microbiome-Host Interaction and Its Role in Metabolic Disease

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Product

Resources

About

The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease