Reduced disease severity following therapeutic treatment with angiotensin 1–7 in a mouse model of multiple sclerosis

Lund, Brett T.; Stone, Roslynn; Levy, Alexander M; Lee, S.; Amundson, Erika; Kashani, Nader; Rodgers, Kathleen E.; Kelland, Eve E.

doi:10.1016/j.nbd.2019.02.018

Cited by 5 publications

(3 citation statements)

References 57 publications

(83 reference statements)

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“…According to the anti-inflammatory and pro-regenerative effects exerted by the Ang(1-7)-MasR axis, the administration of Ang(1-7) in mice undergoing EAE resulted in attenuated disease manifestation, and it was dependent on MasR signaling. This Ang(1-7)-induced EAE amelioration was correlated with decreased immune infiltration, reduced demyelination, and attenuated axonal loss compared with control mice, suggesting a role of the Ang(1-7)-MasR axis in the recruitment of immune cells into the CNS [101].…”

Section: Interaction Between Ras and Dopaminergic System In Neurogenementioning

confidence: 76%

“…According to the anti-inflammatory and pro-regenerative effects exerted by the Ang(1–7)-MasR axis, the administration of Ang(1–7) in mice undergoing EAE resulted in attenuated disease manifestation, and it was dependent on MasR signaling. This Ang(1–7)-induced EAE amelioration was correlated with decreased immune infiltration, reduced demyelination, and attenuated axonal loss compared with control mice, suggesting a role of the Ang(1–7)-MasR axis in the recruitment of immune cells into the CNS [ 101 ]. According to this idea, a previous work demonstrated that MasR signaling in monocytes/macrophages favored inflammatory responses in vivo by increasing monocytes/macrophage migration and infiltration into the spinal cord of EAE mice [ 102 ].…”

Section: Interaction Between Ras and Dopaminergic System In Neurogenementioning

confidence: 99%

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Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation

Campos

Pacheco

2020

Semin Immunopathol

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The renin-angiotensin system (RAS) is a fundamental regulator of blood pressure and has emerged as an important player in the control of inflammatory processes. Accordingly, imbalance on RAS components either systemically or locally might trigger the development of inflammatory disorders by affecting immune cells. At the same time, alterations in the dopaminergic system have been consistently involved in the physiopathology of inflammatory disorders. Accordingly, the interaction between the RAS and the dopaminergic system has been studied in the context of inflammation of the central nervous system (CNS), kidney, and intestine, where they exert antagonistic actions in the regulation of the immune system. In this review, we summarized, integrated, and discussed the cross talk of the dopaminergic system and the RAS in the regulation of inflammatory pathologies, including neurodegenerative disorders, such as Parkinson's disease. We analyzed the molecular mechanisms underlying the interaction between both systems in the CNS and in systemic pathologies. Moreover, we also analyzed the impact of the commensal microbiota in the regulation of RAS and dopaminergic system and how it is involved in inflammatory disorders. Furthermore, we summarized the therapeutic approaches that have yielded positive results in preclinical or clinical studies regarding the use of drugs targeting the RAS and dopaminergic system for the treatment of inflammatory conditions. Further understanding of the molecular and cellular regulation of the RAS-dopaminergic cross talk should allow the formulation of new therapies consisting of novel drugs and/or repurposing already existing drugs, alone or in combination, for the treatment of inflammatory disorders.

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Section: Interaction Between Ras and Dopaminergic System In Neurogenementioning

confidence: 76%

Section: Interaction Between Ras and Dopaminergic System In Neurogenementioning

confidence: 99%

Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation

Campos

Pacheco

2020

Semin Immunopathol

View full text Add to dashboard Cite

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“…Increased expression and activation of detrimental components of RAS have been reported in circulation, cerebrospinal fluid (CSF) and brain tissue (especially on lesions) of MS patients [ 13 , 47 , 275 ], while there was a reduction in the protective ACE2 component [ 13 ]. This observed status in MS patients is associated with exacerbating neurological signs [ 259 , 276 , 277 ]. Importantly, the detrimental axis is activated in the early steps of experimental autoimmune encephalomyelitis (EAE), as an animal model of MS, but the protective axis is activated during the end time point of this model [ 278 ].…”

Section: Introductionmentioning

confidence: 99%

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

et al. 2022

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Coronavirus disease-2019 (COVID-19) is associated with cytokine storm and is characterized by acute respiratory distress syndrome (ARDS) and pneumonia problems. The respiratory system is a place of inappropriate activation of the immune system in people with multiple sclerosis (MS), and this may cause damage to the lung and worsen both MS and infections.The concerns for patients with multiple sclerosis are because of an enhance risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MS patients pose challenges in this pandemic situation, because of the regulatory defect of autoreactivity of the immune system and neurological and respiratory tract symptoms. In this review, we first indicate respiratory issues associated with both diseases. Then, the main mechanisms inducing lung damages and also impairing the respiratory muscles in individuals with both diseases is discussed. At the end, the leading role of physical exercise on mitigating respiratory issues inducing mechanisms is meticulously evaluated.

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Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease

Stone

Liu

Levy

et al. 2019

J Neuroimmune Pharmacol

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Reduced disease severity following therapeutic treatment with angiotensin 1–7 in a mouse model of multiple sclerosis

Abstract: Reduced disease severity following therapeutic treatment with angiotensin 1-7 in a mouse model of multiple sclerosis. Neurobiology of disease, 127, 87-100.

Cited by 5 publications

References 57 publications

Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation

Involvement of dopaminergic signaling in the cross talk between the renin-angiotensin system and inflammation

Respiratory issues in patients with multiple sclerosis as a risk factor during SARS-CoV-2 infection: a potential role for exercise

Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease

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