1998
DOI: 10.1093/ajcp/109.4.431
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Reduced E-Cadherin Immunohistochemical Expression in Node-Negative Breast Carcinomas Correlates With 10-Year Survival

Abstract: R e d u c e d E -C a d h e r i n I m m u n o h i s t o c h e m i c a l

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Cited by 62 publications
(43 citation statements)
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References 20 publications
(27 reference statements)
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“…6,19 In this study, the prevalence of tumors with reduced E-cad expression in sol- id type tumors compared with tubular and tubulopapillary types correlates well with the absence of histological differentiation. Loss of E-cad expression in breast cancer cells can occur by means of multiple mechanisms, including complete or partial gene deletion, promoter inactivation by methylation, and chromatin rearrangement.…”
Section: Discussionsupporting
confidence: 52%
See 1 more Smart Citation
“…6,19 In this study, the prevalence of tumors with reduced E-cad expression in sol- id type tumors compared with tubular and tubulopapillary types correlates well with the absence of histological differentiation. Loss of E-cad expression in breast cancer cells can occur by means of multiple mechanisms, including complete or partial gene deletion, promoter inactivation by methylation, and chromatin rearrangement.…”
Section: Discussionsupporting
confidence: 52%
“…The loss of adhesion function has been associated with malignancy, anaplastic phenotypes, and increased metastatic potential in human carcinomas. 6 Downregulation or reduction of E-cad function caused by mutations in the Ecad gene (CDH1 in humans) has been reported in invasive carcinomas of the breast, bladder, endometrium, liver, lung, ovary, prostate, and thyroid. 3 The availability of different antibodies recognizing cadherins in paraffin sections has allowed the correlation of reduced or lost E-cad immunohistochemical expression with the lack of cohesiveness, higher malignant potential, and invasiveness of epithelial neoplasms of the colon, ovary, stomach, pancreas, lung, breast, head and neck, and other sites in humans.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, quantification of immunoprecipitates with automated computer-assisted devices relying on densitometry allows more objective analysis of results. [24][25][26][27][28][29][30][31] Also, quantitative data are more appropriate for statistical analysis and permit more valid studies, although some variation in interpretation of results can still occur. 32 Our objective in the present study was to determine immunohistochemical criteria for phenotyping of tumors of poor prognosis, and particularly for metastatic risk that would be economically applicable for individual patients with breast carcinoma, using the latest methodology for standardization and quality control.…”
mentioning
confidence: 99%
“…9 In vitro experiments have demonstrated E-cadherin to have invasion-suppressing properties. 10,11 Downregulation of E-cadherin expression has been documented in breast 12 and oesophageal carcinomas, 7 squamous cell carcinomas of the skin 13 and bladder carcinomas. 14 Plakoglobin and b-catenin are closely related proteins that have a key role in cell adhesion (adherens junctions), 15 activation of transcriptional factors, for example, T-cell factor (Tcf) 16 and in the Wnt wingless-signalling pathways, 17 an important pathway in the development of the cell and cancer.…”
mentioning
confidence: 99%