Reduced embryo yield obtained from superstimulated ewes with low circulating AMH concentration is improved by lengthening the FSH treatment

Brochado, C.; Duran, B.J.; Kieffer, J.D.; Pinczak, A.; Menchaca, A.; Garcia-Guerra, A.

doi:10.1016/j.theriogenology.2024.01.024

Theriogenology

2024

DOI: 10.1016/j.theriogenology.2024.01.024

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Reduced embryo yield obtained from superstimulated ewes with low circulating AMH concentration is improved by lengthening the FSH treatment

C. Brochado,

B.J. Duran,

J.D. Kieffer

et al.

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2024

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Cited by 2 publications

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Advances in synchronization and superstimulation for OPU/IVEP: optimizing oocyte quantity and quality

Motta,

Hayden,

Sala

et al. 2024

Reprod. Fertil. Dev.

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The sustained expansion of in vitro embryo production (IVEP) in cattle necessitates ongoing advancements in IVEP methodologies. The success of IVEP largely depends on the quantity and quality (i.e. developmental competence) of oocytes retrieved after ovum pick-up (OPU). The fundamental role of the ovarian follicle in the development of the oocyte highlights the importance of considering the ovarian physiology during development of OPU/IVEP methodologies. Oocyte quantity is largely influenced by ovarian phenotype determined through antral follicle count (AFC) or circulating anti-Müllerian hormone (AMH). In addition, substantial evidence indicates that follicle size and status can affect OPU/IVEP outcomes such that promoting the presence of medium to large sized dominant-like follicles can enhance oocyte developmental competence and thus embryo production. Ovarian superstimulation, using follicle-stimulating hormone (FSH), allows optimization of follicle development and oocyte developmental competence resulting in greater IVEP efficacy. The present review examines various aspects of FSH administration, providing an update of ovarian superstimulation methodologies and their implementation in OPU/IVEP systems. Additionally, the potential development of targeted ovarian superstimulation approaches that consider the marked physiological differences among individuals with varying AFC/AMH phenotypes is explored with the goal of further enhancing IVEP efficacy.

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Advances in synchronization and superstimulation for OPU/IVEP: optimizing oocyte quantity and quality

Motta,

Hayden,

Sala

et al. 2024

Reprod. Fertil. Dev.

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Anti‐Müllerian hormone as a promising novel biomarker for litter size in Romanov sheep

Turgut,

Koca

2024

Reprod Domestic Animals

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Anti‐Müllerian hormone (AMH) is a hormone produced by growing preantral and antral follicles of the ovary. AMH is accepted as an important biomarker for fertility and superovulation parameters in livestock species. This study aimed to evaluate changes in serum AMH level in the oestrous cycle, repeatability of AMH, the effect of age on serum AMH level and the effects of AMH on litter size in Romanov sheep. In the study, a total of 36 Romanov sheep were used as animal material. First blood samples (0th day) were collected from 36 ewes to evaluate AMH and progesterone levels. Second blood samples were collected randomly from 20 ewes 9 days after first sampling to compare AMH levels at two different periods of the oestrous cycle in Romanov ewes. The ewes were categorized into three groups as low, medium and high AMH based on their first AMH levels. Results indicated that serum AMH level did not change during the oestrous and dioestrous phases of the oestrous cycle and two random time points of the oestrous cycle (p > .05). Pearson correlation analysis revealed that there is a high (r = .95) and significant (p < .001) correlation between AMH levels at the 0th (AMH‐1) and 9th (AMH‐2) days. The effect of AMH level on litter size was found to be significant. Litter size was significantly higher in the high AMH group than in the low AMH group (p < .05). In addition, the age of ewes did not affect serum AMH levels (p > .05). ROC analysis indicates that AMH cut‐off value >320 pg/mL with 70% sensitivity and 100% specificity can be used for litter size in Romanov ewes. In conclusion, AMH is highly repeatable and its serum AMH level did not change during the oestrous cycle in Romanov sheep. In addition, AMH affects litter size and can be reliably used as a marker for litter size in Romanov sheep.

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Reduced embryo yield obtained from superstimulated ewes with low circulating AMH concentration is improved by lengthening the FSH treatment

Cited by 2 publications

References 52 publications

Advances in synchronization and superstimulation for OPU/IVEP: optimizing oocyte quantity and quality

Advances in synchronization and superstimulation for OPU/IVEP: optimizing oocyte quantity and quality

Anti‐Müllerian hormone as a promising novel biomarker for litter size in Romanov sheep

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